Vrije Universiteit Brussel — Biomedical Watch V2

Traitements3programmes

Essais2liés

Publications7liées

SourceDBlocale

Traitements

3

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
RadiotherapyEvery year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting. These molecular agents could correspond to immunotherapy and modulators of signaling pathways. More than 50% of cancer patients will receive radiation therapy during the course of their illness, including radiotherapy aimed a palliating symptoms secondary to metastatic diseases. Therefore, there will be an increasing number of patients who will be receiving radiotherapy while they are still receiving molecular agents. A better understanding of the interaction of these two treatment modalities is needed.	Cancer, SEP	Non applicable	Traitement symptomatique	Belgium	À vérifier
ShamRespiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis. Both diseases are progressive degenerating diseases that cause difficulties in breathing, airway protection and swallowing. Patients with PD and MS typically become sedentary and lose endurance, maximal fitness levels and overall pulmonary function. Much of the research focus has been on the motor symptoms of PD and MS yet the pulmonary and swallowing complications are perhaps ultimately the most important disability as the diseases progress. The inability to generate adequate respiratory pressure is responsible for reduced cough magnitudes and cough response times. Cough is critical for the clearance of foreign materials in the airway helping to reduce infiltration of bacteria and subsequent respiratory infection. With reduced cough function an increased risk for pulmonary disease occurs due to a reduced ability to protect the airways. There are a number of promising outcomes from an expiratory strength-training program. By increasing expiratory muscle strength and expiratory pressure generation, effective breathing, clearance of the airway, and improved swallowing can occur. These explicit outcomes are predicted based on our experience with the use of an innovative device-driven, home-based expiratory strength training program focused on the expiratory muscles of respiration. This project focuses on following patients with PD and MS for an initial 5 weeks of strength training and them testing the outcome of a caregiver program for maintaining treatment effects.	Migraine, SEP	Non applicable	Traitement symptomatique	Belgium	À vérifier
RadiotherapyEvery year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting. These molecular agents could correspond to immunotherapy and modulators of signaling pathways. More than 50% of cancer patients will receive radiation therapy during the course of their illness, including radiotherapy aimed a palliating symptoms secondary to metastatic diseases. Therefore, there will be an increasing number of patients who will be receiving radiotherapy while they are still receiving molecular agents. A better understanding of the interaction of these two treatment modalities is needed.	Cancer	À vérifier	Traitement symptomatique	Canada	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
transcutaneous vagus nerve stimulation	SEP	Non applicable	NCT03553485	Effects of VNS on RT-induced Inflammation and Prognosis of Patients With NSCLC	UNKNOWN
Radiotherapy	Cancer	À vérifier	NCT04115267	Attribution of Toxicities Due to Radiotherapy and Immuno-Biological Therapies	RECRUITING

Publications

7

Molécule	Indication / population	Titre	Journal	Date
Sham		Protective effects of polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats.	Redox report : communications in free radical research
Sham		Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.	Clinical and experimental hypertension (New York, N.Y. : 1993)
Sham		Mailuo Shutong pills alleviate limb swelling in femoral fracture rats by orchestrating mitophagic clearance and ferroptotic suppression.	Journal of ethnopharmacology
Sham		Intermittent Theta Burst Stimulation Improves Sleep in Autism Spectrum Disorder by Reorganizing Overlapping Brain Networks With Neurochemical and Transcriptomic Signatures: A Randomized Controlled Trial.	CNS neuroscience & therapeutics
Sham		Role of Hypoxia-Inducible Factor-1α in Regulating Muscle Degeneration After Rotator Cuff Tears.	The American journal of sports medicine
Sham		Chronic 3.5 GHz radiofrequency exposure is associated with behavioral, molecular, and histopathological changes in the rat hippocampus.	International journal of radiation biology
Sham		Efficacy and safety of acupuncture treatment for depression: A systematic review and meta-analysis.	Medicine