Vanderbilt University — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications5liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
TrimethaphanThe purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants will be screened for the study. The investigators estimate 16 will be eligible to participate in all of the study days.	Hypertension	Phase 1	À vérifier	United States	À vérifier
TrimethaphanThe purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants will be screened for the study. The investigators estimate 16 will be eligible to participate in all of the study days.	Hypertension	Phase 1	À vérifier	United States	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Trimethaphan	Hypertension	Phase 1	NCT02726711	Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic	ACTIVE_NOT_RECRUITING

Publications

5

Molécule	Indication / population	Titre	Journal	Date
Trimethaphan		Autonomic neural control of dynamic cerebral autoregulation in humans.	Circulation
Trimethaphan		Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations.	Journal of applied physiology (Bethesda, Md. : 1985)
Trimethaphan		Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin.	American journal of physiology. Heart and circulatory physiology
Trimethaphan		Protective effect of biogenic selenium nanoparticles against diquat-induced acute toxicity via regulation of gut microbiota and its metabolites.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Trimethaphan		Complete autonomic blockade reveals nitric oxide contribution to blood pressure regulation in obese Black women.	Clinical autonomic research : official journal of the Clinical Autonomic Research Society