University of Sao Paulo — Biomedical Watch V2

Traitements6programmes

Essais3liés

Publications3liées

SourceDBlocale

Traitements

6

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
AyahuascaOpen label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)	Épilepsie	Phase 1/2	À vérifier	Brazil	À vérifier
Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without MigraineThis study comprised two separate assessor-blinded randomized crossover experiments, one in participants with migraine and one in participants without migraine. Within each cohort, participants completed two experimental conditions on separate study visits: 10 minutes of self-selected personal prayer and 10 minutes of non-spiritual reading. The order of the two conditions was randomized within each cohort. The primary outcome was cephalic pressure pain threshold (PPT), assessed immediately before and after each experimental condition at eight craniofacial sites. The study examined acute changes in PPT following prayer and reading. Spiritual well-being, religiosity, anxiety symptoms, and depressive symptoms were assessed once at baseline to characterize the participants and were not repeated following the experimental conditions. A total of 109 participants were enrolled: 57 participants with migraine and 52 participants without migraine.	Migraine	Non applicable	Traitement symptomatique	Brazil	À vérifier
SLE-OMEGA — Omega-3 Supplementation in Systemic Lupus ErythematosusThis randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether oral omega-3 fatty acid supplementation can modulate inflammation, oxidative stress, and telomere maintenance in women with systemic lupus erythematosus (SLE) in remission. Women aged 18-45 years with SLE (SLEDAI-2K ≤ 4) will be allocated to receive either omega-3 (5,400 mg/day of EPA+DHA) or placebo for 12 weeks. A parallel healthy control group will undergo the same intervention scheme. Clinical, biochemical, and molecular assessments including inflammatory cytokines, oxidative stress markers (TBARS, ORAC, T-AOC), and relative telomere length (T/S ratio) will be conducted at baseline and post-intervention. The trial is designed to determine whether omega-3 can attenuate chronic low-grade inflammation and oxidative imbalance, both key drivers of cellular dysfunction and premature immunosenescence in SLE. Omega-3 PUFAs exert anti-inflammatory effects through competition with arachidonic acid for COX/LOX enzymes and by activating GPR120, which inhibits the TAK1-NF-κB-JNK inflammatory cascade. Their antioxidant effects may further reduce reactive oxygen species and support genomic stability. By integrating clinical, biochemical, and molecular outcomes, this study provides a comprehensive evaluation of omega-3 effects on pathways implicated in accelerated cellular aging in autoimmune diseases. The findings are expected to clarify whether omega-3 supplementation represents a safe, low-cost strategy capable of improving inflammatory and oxidative profiles and contributing to telomere preservation in women with SLE, supporting future precision-nutrition approaches in this population.	Lupus	Non applicable	Immunomodulation + Neuroprotection		À vérifier
AyahuascaOpen label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)	Épilepsie	Phase 1/2	À vérifier	Brazil	À vérifier
SLE-OMEGA — Omega-3 Supplementation in Systemic Lupus ErythematosusThis randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether oral omega-3 fatty acid supplementation can modulate inflammation, oxidative stress, and telomere maintenance in women with systemic lupus erythematosus (SLE) in remission. Women aged 18-45 years with SLE (SLEDAI-2K ≤ 4) will be allocated to receive either omega-3 (5,400 mg/day of EPA+DHA) or placebo for 12 weeks. A parallel healthy control group will undergo the same intervention scheme. Clinical, biochemical, and molecular assessments including inflammatory cytokines, oxidative stress markers (TBARS, ORAC, T-AOC), and relative telomere length (T/S ratio) will be conducted at baseline and post-intervention. The trial is designed to determine whether omega-3 can attenuate chronic low-grade inflammation and oxidative imbalance, both key drivers of cellular dysfunction and premature immunosenescence in SLE. Omega-3 PUFAs exert anti-inflammatory effects through competition with arachidonic acid for COX/LOX enzymes and by activating GPR120, which inhibits the TAK1-NF-κB-JNK inflammatory cascade. Their antioxidant effects may further reduce reactive oxygen species and support genomic stability. By integrating clinical, biochemical, and molecular outcomes, this study provides a comprehensive evaluation of omega-3 effects on pathways implicated in accelerated cellular aging in autoimmune diseases. The findings are expected to clarify whether omega-3 supplementation represents a safe, low-cost strategy capable of improving inflammatory and oxidative profiles and contributing to telomere preservation in women with SLE, supporting future precision-nutrition approaches in this population.	Lupus	Non applicable	Immunomodulation + Neuroprotection		À vérifier
Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without MigraineThis study comprised two separate assessor-blinded randomized crossover experiments, one in participants with migraine and one in participants without migraine. Within each cohort, participants completed two experimental conditions on separate study visits: 10 minutes of self-selected personal prayer and 10 minutes of non-spiritual reading. The order of the two conditions was randomized within each cohort. The primary outcome was cephalic pressure pain threshold (PPT), assessed immediately before and after each experimental condition at eight craniofacial sites. The study examined acute changes in PPT following prayer and reading. Spiritual well-being, religiosity, anxiety symptoms, and depressive symptoms were assessed once at baseline to characterize the participants and were not repeated following the experimental conditions. A total of 109 participants were enrolled: 57 participants with migraine and 52 participants without migraine.	Migraine	Non applicable	Traitement symptomatique	Brazil	À vérifier

Essais cliniques

3

Molécule	Indication / population	Phase	NCT	Titre	Statut
Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without Migraine	Migraine	Non applicable	NCT07143461	Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without Migraine	COMPLETED
SLE-OMEGA — Omega-3 Supplementation in Systemic Lupus Erythematosus	Lupus	Non applicable	NCT07393399	SLE-OMEGA — Omega-3 Supplementation in Systemic Lupus Erythematosus	NOT_YET_RECRUITING
Ayahuasca	Épilepsie	Phase 1/2	NCT07747324	Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial	RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Ayahuasca		Barriers and Facilitators for Psychedelic Research and Regulation in Brazil: Insights From Diverse Stakeholders.	Clinical therapeutics
Ayahuasca		Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.	Journal of psychopharmacology (Oxford, England)
Ayahuasca		Therapeutic properties of ayahuasca component N,N-Dimethyltryptamine in a pre-clinical model of Parkinson's disease.	Experimental neurology