University of Santiago de Compostela — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications5liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Transcranial electrical stimulationRefractory chronic pain represents a serious and limiting health condition which does not respond to standard pharmacological therapy. Thus, it emerges the necessity of new techniques to treat these group of diseases, such as the transcranial electrical stimulation (tES). This procedure induces a low-intensity electrical current through the scalp to modify the excitability of brain cells, thus facilitating changes in neural networks which may be dysfunctional in some chronic pain patients. The main objective of this research is to test the efficacy of two tES techniques, differentiated by applying direct or alternant electrical current, to reduce the pain intensity and to increase pain thresholds of these patients. Besides, intervention is implemented at home for patients themselves thanks to a portable and convenient stimulator device, after one training session provided by technicians. Researches can supervise the compliance of the treatment remotely, as the stimulator has a permanent connection with their computers. A home-based approach means a more comfortable and accessible treatment alternative for patients, since they do not have to attend to clinics everyday to receive the stimulation; the advantages become even more relevant in the pandemic context, since the risk of being infected is radically minimized. Despite the main purpose is to test the efficacy of tES to improve the pain suffered by patients, many other areas are considered as secondary end points for being intrinsically linked or affected by the disease, such as the interference in daily tasks provoked by pain, mood disorders (depression/anxiety), fatigue, life quality, physical functioning and sleep quality; these last two variables are measured with actigraph wristwatches, apart from specific questionnaires. Lastly, endogenous modulatory pain mechanisms are examined through sensory tests, namely Conditioned Pain Modulation and Temporal Summation of pain.	Migraine	Non applicable	Traitement symptomatique	Spain	À vérifier
Transcranial electrical stimulationRefractory chronic pain represents a serious and limiting health condition which does not respond to standard pharmacological therapy. Thus, it emerges the necessity of new techniques to treat these group of diseases, such as the transcranial electrical stimulation (tES). This procedure induces a low-intensity electrical current through the scalp to modify the excitability of brain cells, thus facilitating changes in neural networks which may be dysfunctional in some chronic pain patients. The main objective of this research is to test the efficacy of two tES techniques, differentiated by applying direct or alternant electrical current, to reduce the pain intensity and to increase pain thresholds of these patients. Besides, intervention is implemented at home for patients themselves thanks to a portable and convenient stimulator device, after one training session provided by technicians. Researches can supervise the compliance of the treatment remotely, as the stimulator has a permanent connection with their computers. A home-based approach means a more comfortable and accessible treatment alternative for patients, since they do not have to attend to clinics everyday to receive the stimulation; the advantages become even more relevant in the pandemic context, since the risk of being infected is radically minimized. Despite the main purpose is to test the efficacy of tES to improve the pain suffered by patients, many other areas are considered as secondary end points for being intrinsically linked or affected by the disease, such as the interference in daily tasks provoked by pain, mood disorders (depression/anxiety), fatigue, life quality, physical functioning and sleep quality; these last two variables are measured with actigraph wristwatches, apart from specific questionnaires. Lastly, endogenous modulatory pain mechanisms are examined through sensory tests, namely Conditioned Pain Modulation and Temporal Summation of pain.	Migraine	Non applicable	Traitement symptomatique	Spain	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Transcranial electrical stimulation	Migraine	Non applicable	NCT05099406	Home-based Transcranial Stimulation in the Treatment of Patients With Refractory Chronic Pain	UNKNOWN

Publications

5

Molécule	Indication / population	Titre	Journal	Date
Transcranial electrical stimulation		Acute stress alters prefrontal resting-state networks and tES restores functional connectivity.	Journal of affective disorders
Transcranial electrical stimulation		Multimodal intraoperative monitoring of facial nerve function: combined use of blink reflex and corticobulbar motor evoked potentials.	Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Transcranial electrical stimulation		Thalamic transcranial electrical stimulation with temporal interference enhances sleep spindle activity during a daytime nap.	Sleep advances : a journal of the Sleep Research Society
Transcranial electrical stimulation		[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health].	Der Nervenarzt
Transcranial electrical stimulation		Neural changes to transcranial alternating current stimulation in the gamma range over the left frontoparietal network: A preliminary eLORETA EEG study.	AIMS neuroscience