University of Roma La Sapienza — Biomedical Watch V2

Traitements10programmes

Essais5liés

Publications8liées

SourceDBlocale

Traitements

10

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
A Ketogenic Diet Acts on Cortical But Not Subcortical Responsivity in MigraineursA short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, investigators aim to prove if the KD-related changes of cortical excitability are primarily due to cerebral cortex activity or are modulated by the brainstem. Through the stimulation of the right supraorbital division of the trigeminal nerve, there will be concurrently interictally recorded the nociceptive blink reflex (nBR) and the pain-related evoked potentials (PREP) in 18 migraineurs patients without aura before and after 1-month on KD, while in metabolic ketosis. nBR and PREP reflect distinct brain structures activation: the brainstem and the cerebral cortex respectively. It will be estimated nBR R2 component area-under-the-curve as well as PREP amplitude habituation as the slope of the linear regression between the 1st and the 2nd block of 5 averaged responses.	Migraine	NA	Traitement symptomatique	Italy	À vérifier
CHRONOpS — Chronology and Sequence of Premonitory SymptomsThe purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.	Migraine	À vérifier	Traitement symptomatique	Italy	À vérifier
Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)Patients with unresectable pancreatic cancer in most of cases cannot benefit from percutaneous ablation modalities, due to high risk of procedure-related complications. Ultrasound-guided high intensity focused ultrasound (HIFU) ablation has been introduced as a feasible treatment option in these patients. However, in other anatomical regions US-guided HIFU has been replaced by the more accurate MR-guided focused ultrasound (MRgFUS) ablation, but the applicability of this latter technique to the treatment of pancreatic cancer is still unexplored. The aim of this study is to explore feasibility and clinical performance of MRgFUS ablation of unresectable pancreatic cancer. Two are the main end-points: Pain palliation and local tumor control. As compared to conventional US-guided HIFU, MRgFUS could represent a more accurate, non-invasive ablation modality even for unresectable pancreatic cancer although, to date, no cases of pancreatic MRgFUS ablation have been reported.	Cancer	À vérifier	Traitement symptomatique	Italy	À vérifier
RosuvastatinThe primary objective of this study is to test the hypothesis that twice overnight high-dose rosuvastatin loading before RNA followed by 3-month treatment with regular doses of rosuvastatin can reduce both the acute and late renal artery damage.	Hypertension	Phase 4	À vérifier	Italy	À vérifier
Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic MigraineThe purpose of this study is to assess short- and long-term safety, tolerability and efficacy of cervical High Frequency Spinal Cord Stimulation (HF-SCS) in patients suffering from chronic migraine refractory to conventional medical therapy.	Migraine	NA	À vérifier	Italy	À vérifier
Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic MigraineThe purpose of this study is to assess short- and long-term safety, tolerability and efficacy of cervical High Frequency Spinal Cord Stimulation (HF-SCS) in patients suffering from chronic migraine refractory to conventional medical therapy.	Migraine	Non applicable	À vérifier	Italy	À vérifier
A Ketogenic Diet Acts on Cortical But Not Subcortical Responsivity in MigraineursA short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, investigators aim to prove if the KD-related changes of cortical excitability are primarily due to cerebral cortex activity or are modulated by the brainstem. Through the stimulation of the right supraorbital division of the trigeminal nerve, there will be concurrently interictally recorded the nociceptive blink reflex (nBR) and the pain-related evoked potentials (PREP) in 18 migraineurs patients without aura before and after 1-month on KD, while in metabolic ketosis. nBR and PREP reflect distinct brain structures activation: the brainstem and the cerebral cortex respectively. It will be estimated nBR R2 component area-under-the-curve as well as PREP amplitude habituation as the slope of the linear regression between the 1st and the 2nd block of 5 averaged responses.	Migraine	NA	Traitement symptomatique	Italy	À vérifier
RosuvastatinThe primary objective of this study is to test the hypothesis that twice overnight high-dose rosuvastatin loading before RNA followed by 3-month treatment with regular doses of rosuvastatin can reduce both the acute and late renal artery damage.	Hypertension	Phase 4	À vérifier	Italy	À vérifier
CHRONOpS — Chronology and Sequence of Premonitory SymptomsThe purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.	Migraine	À vérifier	Traitement symptomatique	Italy	À vérifier
Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)Patients with unresectable pancreatic cancer in most of cases cannot benefit from percutaneous ablation modalities, due to high risk of procedure-related complications. Ultrasound-guided high intensity focused ultrasound (HIFU) ablation has been introduced as a feasible treatment option in these patients. However, in other anatomical regions US-guided HIFU has been replaced by the more accurate MR-guided focused ultrasound (MRgFUS) ablation, but the applicability of this latter technique to the treatment of pancreatic cancer is still unexplored. The aim of this study is to explore feasibility and clinical performance of MRgFUS ablation of unresectable pancreatic cancer. Two are the main end-points: Pain palliation and local tumor control. As compared to conventional US-guided HIFU, MRgFUS could represent a more accurate, non-invasive ablation modality even for unresectable pancreatic cancer although, to date, no cases of pancreatic MRgFUS ablation have been reported.	Cancer	À vérifier	Traitement symptomatique	Italy	À vérifier

Essais cliniques

5

Molécule	Indication / population	Phase	NCT	Titre	Statut
Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)	Cancer	À vérifier	NCT01786850	Magnetic Resonance-guided High-intensity Focused Ultrasound Treatment of Locally Advanced Pancreatic Cancer	AVAILABLE
CHRONOpS — Chronology and Sequence of Premonitory Symptoms	Migraine	À vérifier	NCT07681466	CHRONOpS — Chronology and Sequence of Premonitory Symptoms	RECRUITING
Rosuvastatin	Hypertension	Phase 4	NCT01899027	ARTEMISIA — Rosuvastatin for Preventing Complications in Renal Ablation	UNKNOWN
A Ketogenic Diet Acts on Cortical But Not Subcortical Responsivity in Migraineurs	Migraine	NA	NCT03775252	A Ketogenic Diet Acts on Cortical But Not Subcortical Responsivity in Migraineurs	COMPLETED
Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine	Migraine	Non applicable	NCT01653340	rCM HF-SCS — A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine	COMPLETED

Publications

8

Molécule	Indication / population	Titre	Journal	Date
Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)		A Magnetic Resonance-Compatible Fiberoptic Temperature Sensor for Measuring Focused Ultrasound-Induced Heating Without Artifacts.	Ultrasound in medicine & biology
Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)		Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound for Treating Essential Tremor: Systematic Review and Meta-Analysis.	Movement disorders clinical practice
Magnetic Resonance-guided High-intensity Focused Ultrasound (MRgFUS)		Safety and efficacy of magnetic resonance-guided high-intensity focused ultrasound surgery (MRgFUS) in adenomyosis with dysmenorrhea.	Abdominal radiology (New York)
Rosuvastatin		Rosuvastatin calcium and pravastatin sodium regulate the antioxidant system in zebrafish liver through the PI3K/Nrf2/ARE signaling pathway.	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
Rosuvastatin		Rosuvastatin ameliorates high-altitude cerebral edema by promoting blood-brain barrier integrity via the regulation of energy metabolism.	Free radical biology & medicine
Rosuvastatin		Shenling Jiangzhi formula alleviates atherosclerosis in ApoE mice by inhibiting vascular inflammation via the NF-κB/NLRP3 pathway.	Journal of ethnopharmacology
Rosuvastatin		Gilteritinib-Associated Hypertriglyceridemia During Acute Myeloid Leukemia Triplet Therapy in a 52-Year-Old Man: A Case Report.	Cureus
Rosuvastatin		Assessment of periodontal regeneration with blood derivatives: a systematic review and network meta-analysis.	Odontology