University of Rochester — Biomedical Watch V2

Traitements8programmes

Essais5liés

Publications5liées

SourceDBlocale

Traitements

8

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
CreatineDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Parkinson, Sclérose latérale amyotrophique	Phase 3	À vérifier	United States, Canada	À vérifier
Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their CaregiversThe purpose of this study is to evaluate the efficacy of Dyadic Life Review (DLR) therapy for reducing caregiver distress, measured by caregiver burden to capture the multifaceted experience of distress, among older adults with advanced cancer and cognitive impairment and their caregivers.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic DystrophyMyotonic dystrophy type 1 (DM1) can affect people in many different ways, even in the same family. The symptoms that children experience can be different and more severe than adults. Prior studies in children have been limited because only a small number of children could participate. In this study, we hope to learn more about these differences and what causes them. This is an observational study conducted in participants' homes and does not require travel. Instead, we will use video calls to talk with children and their parents/guardians about DM1 symptoms and how it affects the child's muscles, heart, and brain. We'll send families an iPad and the other tools they need for the study. During the video call, kids will do some simple activities to see how their body moves and functions. Parents/guardians might need to help their child with some of these activities. After the video visit, we'll get a small blood sample from the child. This can be done at a local lab or even at home. We'll then look at the child's genes in the blood sample to understand how they might be linked to their symptoms. Parents/guardians can chose to have their child's genetic test result returned to them.	Myopathies	À vérifier	Traitement symptomatique	United States	À vérifier
The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular DystrophyThe aim of the BABY DUCHENNE study is to evaluate the natural history and characterize the early clinical outcomes in very young children (0-3 years) with Duchenne muscular dystrophy (DMD) identified by newborn screening programs.	Myopathies	À vérifier	À vérifier	United States	À vérifier
REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic DystrophyMyotonic dystrophy type 1 (DM1) can affect people in many different ways, even in the same family. The symptoms that children experience can be different and more severe than adults. Prior studies in children have been limited because only a small number of children could participate. In this study, we hope to learn more about these differences and what causes them. This is an observational study conducted in participants' homes and does not require travel. Instead, we will use video calls to talk with children and their parents/guardians about DM1 symptoms and how it affects the child's muscles, heart, and brain. We'll send families an iPad and the other tools they need for the study. During the video call, kids will do some simple activities to see how their body moves and functions. Parents/guardians might need to help their child with some of these activities. After the video visit, we'll get a small blood sample from the child. This can be done at a local lab or even at home. We'll then look at the child's genes in the blood sample to understand how they might be linked to their symptoms. Parents/guardians can chose to have their child's genetic test result returned to them.	Myopathies	À vérifier	Traitement symptomatique	United States	À vérifier
CreatineThe objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS.	Parkinson	Phase 3	À vérifier	United States, Canada	À vérifier
The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular DystrophyThe aim of the BABY DUCHENNE study is to evaluate the natural history and characterize the early clinical outcomes in very young children (0-3 years) with Duchenne muscular dystrophy (DMD) identified by newborn screening programs.	Myopathies	À vérifier	À vérifier	United States	À vérifier
Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their CaregiversThe purpose of this study is to evaluate the efficacy of Dyadic Life Review (DLR) therapy for reducing caregiver distress, measured by caregiver burden to capture the multifaceted experience of distress, among older adults with advanced cancer and cognitive impairment and their caregivers.	Alzheimer	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

5

Molécule	Indication / population	Phase	NCT	Titre	Statut
Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers	Alzheimer	Non applicable	NCT07796347	Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers	NOT_YET_RECRUITING
The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular Dystrophy	Myopathies	À vérifier	NCT07092540	The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular Dystrophy	RECRUITING
Creatine	Parkinson	Phase 3	NCT00449865	NET-PD LS-1 Creatine in Parkinson's Disease	TERMINATED
REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic Dystrophy	Myopathies	À vérifier	NCT07630389	REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic Dystrophy	RECRUITING
Minocycline	Parkinson	Phase 2	NCT00063193	National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial	COMPLETED

Publications

5

Molécule	Indication / population	Titre	Journal	Date
Creatine		Real-world creatine supplementation: a large-scale cross-sectional study of use, knowledge, and experiences.	Journal of the International Society of Sports Nutrition
Creatine		Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition.	Journal of the International Society of Sports Nutrition
Creatine		Shuxin oral liquid attenuates isoproterenol-induced myocardial fibrosis in rats: Association with downregulation of the TGF-β/Smad signaling pathway.	Journal of ethnopharmacology
Creatine		Metabolomic Insights on Obesity and Diabetes from Feeding Diets Varying in Carbohydrate-Fat Ratios in Zucker Diabetic Fatty (ZDF) and Lean Zucker (Z) Rats.	International journal of molecular sciences
Creatine		Delayed Serum Creatine Kinase Elevation After Snakebite: Serial Changes and Clinical Correlates of Myotoxicity in a Korean Tertiary-Care Cohort.	Journal of clinical medicine