University of Pittsburgh — Biomedical Watch V2

Traitements6programmes

Essais3liés

Publications6liées

SourceDBlocale

Traitements

6

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Flexible Representation of SpeechThe overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratemporal plane, comprised of Heschl's gyrus, the planum polare, and the planum temporale, is capable of the rapid spectrotemporal analysis required to map acoustic information to linguistic representation. Neural activity in this area, however, is rarely studied directly because it is difficult to access with non-invasive measures like scalp electroencephalography (EEG). Capitalizing on the unique opportunity to access these areas via routine clinical stereoelectroencephalography (sEEG) in a patient population, this study seeks to understand how cortical responses reflect the diagnosticity of two acoustic-phonetic dimensions of interest and how responses rapidly and flexibly adapt to changes in listening demands. Examining how neural response to voice onset time (VOT) and fundamental frequency (F0) modulates as a function of perceptual weight carried in signaling phoneme categories, and identifying how changes in listening context shift perceptual weight, will provide invaluable data that indicates how speech processing flexibly adapts to short-term acoustic patterns.	Épilepsie	NA	À vérifier	United States	À vérifier
HART — Evaluating the Effectiveness of the Health App Recommendation ToolThis study aims to assess the effectiveness of the Health App Recommendation Tool (HART), an evidence-based tool that evaluates app features and matches them to the needs, abilities, and preferences of individuals with Alzheimer's disease and related dementias (ADRD) or their caregivers. This novel tool is not an app in and of itself, but rather an assessment tool used to determine how well suited a given app is for a member of the ADRD or caregiver population. Specifically, the objective of this research is to assess the acceptability of the current HART design among target end-users in their individual contexts. The overarching goal of this project is to connect those in the ADRD community with available, usable, and effective digital tools to promote the highest possible level of health and wellness in community settings. To achieve this goal, the study will recruit 15 family caregivers living with their loved ones with ADRD, who will trial HART and provide feedback. Participation will include two data collection sessions (pre-intervention and post-intervention) within a four-week trial period. Participants will be asked to complete the HART, explore the recommended apps, and provide feedback on HART's usability through several brief surveys.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
Real World Testing of a Brain-Computer InterfaceDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	À vérifier	À vérifier	United States	À vérifier
Real World Testing of a Brain-Computer InterfaceDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	À vérifier	À vérifier	United States	À vérifier
Flexible Representation of SpeechThe overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratemporal plane, comprised of Heschl's gyrus, the planum polare, and the planum temporale, is capable of the rapid spectrotemporal analysis required to map acoustic information to linguistic representation. Neural activity in this area, however, is rarely studied directly because it is difficult to access with non-invasive measures like scalp electroencephalography (EEG). Capitalizing on the unique opportunity to access these areas via routine clinical stereoelectroencephalography (sEEG) in a patient population, this study seeks to understand how cortical responses reflect the diagnosticity of two acoustic-phonetic dimensions of interest and how responses rapidly and flexibly adapt to changes in listening demands. Examining how neural response to voice onset time (VOT) and fundamental frequency (F0) modulates as a function of perceptual weight carried in signaling phoneme categories, and identifying how changes in listening context shift perceptual weight, will provide invaluable data that indicates how speech processing flexibly adapts to short-term acoustic patterns.	Épilepsie	NA	À vérifier	United States	À vérifier
HART — Evaluating the Effectiveness of the Health App Recommendation ToolThis study aims to assess the effectiveness of the Health App Recommendation Tool (HART), an evidence-based tool that evaluates app features and matches them to the needs, abilities, and preferences of individuals with Alzheimer's disease and related dementias (ADRD) or their caregivers. This novel tool is not an app in and of itself, but rather an assessment tool used to determine how well suited a given app is for a member of the ADRD or caregiver population. Specifically, the objective of this research is to assess the acceptability of the current HART design among target end-users in their individual contexts. The overarching goal of this project is to connect those in the ADRD community with available, usable, and effective digital tools to promote the highest possible level of health and wellness in community settings. To achieve this goal, the study will recruit 15 family caregivers living with their loved ones with ADRD, who will trial HART and provide feedback. Participation will include two data collection sessions (pre-intervention and post-intervention) within a four-week trial period. Participants will be asked to complete the HART, explore the recommended apps, and provide feedback on HART's usability through several brief surveys.	Alzheimer	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

3

Molécule	Indication / population	Phase	NCT	Titre	Statut
HART — Evaluating the Effectiveness of the Health App Recommendation Tool	Alzheimer	Non applicable	NCT07216716	HART — Evaluating the Effectiveness of the Health App Recommendation Tool	RECRUITING
Flexible Representation of Speech	Épilepsie	NA	NCT05209386	Flexible Representation of Speech	COMPLETED
Real World Testing of a Brain-Computer Interface	Sclérose latérale amyotrophique	À vérifier	NCT04026581	Real World Testing of a Brain-Computer Interface	COMPLETED

Publications

6

Molécule	Indication / population	Titre	Journal	Date
Flexible Representation of Speech		Working memory load attenuates the match effect in sentence-picture verification.	Memory & cognition
Real World Testing of a Brain-Computer Interface		Artificial intelligence in rehabilitation: a review of clinical effectiveness, real-world performance, safety, and equity across modalities and settings.	Frontiers in digital health
Flexible Representation of Speech		LlymX: Multimodal LLM-Augmented XR for Context-Aware Information Access.	IEEE computer graphics and applications
Flexible Representation of Speech		Deep Learning Reveals Cross-Modal Neural Representations of Auditory and Visual Mental Imagery in MEG.	Journal of neurophysiology
Real World Testing of a Brain-Computer Interface		Reproducible testing for embedded BCIs: a demultiplexing PCB and acquisition system for EEG signal emulation.	HardwareX
Real World Testing of a Brain-Computer Interface		Neural decoding of speech using deep neural ensembles.	bioRxiv : the preprint server for biology