University of Mississippi Medical Center — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications9liées

SourceDBlocale

Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
baclofenOral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although for adults there is dosing,safety and efficacy information in the package insert, this is not the case for children. The purpose of this study is to determine how fast the drug is cleared from the body, the correct dose, and long-term safety and efficacy for children with spasticity.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
TizanidineMuscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain. Oral medications are the usual first-line treatment, but many people report limited benefit or side effects. This study examines a non-surgical method called transcutaneous spinal stimulation. Surface electrodes are placed on the lower back and on the abdomen, and an electrical current is passed between them to activate nerve fibers entering the spinal cord. Adults who have had a spinal cord injury and have muscle stiffness or spasms in the legs may participate. Each participant takes part in all parts of the study and serves as their own comparison. Participants attend four visits at one study site, about one week apart. The first visit is for consent and a clinical examination. At each of the next three visits, the participant receives one capsule containing tizanidine, baclofen, or an inactive substance (placebo), in an order assigned by chance. One hour later, the participant receives two 15-minute periods of spinal stimulation, one at 30 pulses per second and one at 75 pulses per second, also in an order assigned by chance. Neither the participant nor the person conducting the testing knows which capsule was taken. Leg reflexes, muscle activity, and knee movement are measured before the capsule is taken, one hour after it is taken, during each period of stimulation, and after each period of stimulation. Clinical scales for stiffness and spasms are also scored. The study compares the two stimulation rates, compares stimulation with each medicine given alone, and examines whether adding stimulation to a medicine has a larger effect than stimulation alone.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
baclofenOral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although for adults there is dosing,safety and efficacy information in the package insert, this is not the case for children. The purpose of this study is to determine how fast the drug is cleared from the body, the correct dose, and long-term safety and efficacy for children with spasticity.	Myopathies	Phase 1	Traitement symptomatique	United States	À vérifier
TizanidineMuscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain. Oral medications are the usual first-line treatment, but many people report limited benefit or side effects. This study examines a non-surgical method called transcutaneous spinal stimulation. Surface electrodes are placed on the lower back and on the abdomen, and an electrical current is passed between them to activate nerve fibers entering the spinal cord. Adults who have had a spinal cord injury and have muscle stiffness or spasms in the legs may participate. Each participant takes part in all parts of the study and serves as their own comparison. Participants attend four visits at one study site, about one week apart. The first visit is for consent and a clinical examination. At each of the next three visits, the participant receives one capsule containing tizanidine, baclofen, or an inactive substance (placebo), in an order assigned by chance. One hour later, the participant receives two 15-minute periods of spinal stimulation, one at 30 pulses per second and one at 75 pulses per second, also in an order assigned by chance. Neither the participant nor the person conducting the testing knows which capsule was taken. Leg reflexes, muscle activity, and knee movement are measured before the capsule is taken, one hour after it is taken, during each period of stimulation, and after each period of stimulation. Clinical scales for stiffness and spasms are also scored. The study compares the two stimulation rates, compares stimulation with each medicine given alone, and examines whether adding stimulation to a medicine has a larger effect than stimulation alone.	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Tizanidine	Myopathies	Non applicable	NCT07792616	Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity	ACTIVE_NOT_RECRUITING
baclofen	Myopathies	Phase 1	NCT00607542	Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity	COMPLETED

Publications

9

Molécule	Indication / population	Titre	Journal	Date
baclofen		Downbeat nystagmus: a practical approach based on a clinical case.	Arquivos de neuro-psiquiatria
baclofen		Intrathecal Baclofen Pump Therapy for Medically Refractory Stiff Person Syndrome: A Multicenter Case Series.	Neuromodulation : journal of the International Neuromodulation Society
baclofen		On-Demand Hospital Manufacturing of Baclofen Lozenges Using Pharmaceutical 3D Printing.	Pharmaceutical research
baclofen		Persistent hiccups following endobronchial ultrasound-guided transbronchial needle aspiration.	Respiratory medicine case reports
baclofen		Six approved drugs for alcohol use disorder: algorithms for their use according to the aims of treatment.	Alcohol and alcoholism (Oxford, Oxfordshire)
baclofen		Global Research Trends in the Surgical Management of Spasticity: A Systematic Review and Bibliometric Analysis.	Stereotactic and functional neurosurgery
baclofen		Perioperative Pregabalin for Recurrent Intractable Hiccups: A Case Report and Literature Review.	Case reports in anesthesiology
baclofen		Long-Term Effects of Early Postnatal Administration of R-Baclofen on Neuronal Properties in the Knockout Rat.	Journal of integrative neuroscience
baclofen		Activation of GABAR alleviates colitis by reprogramming macrophage polarization via the IRAK-M/NLRP3/NF-κB pathway.	Biochemical pharmacology