University of Michigan — Biomedical Watch V2

Traitements24programmes

Essais11liés

Publications12liées

SourceDBlocale

Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Brain Computer Interface KeyboardThe purpose of this research is to develop tools enable people who are paralyzed to operate technology and access computers. These tools are called brain computer interfaces (BCIs). BCIs would let a person use brain signals to operate technology.	Sclérose latérale amyotrophique	Phase 1	À vérifier	United States	À vérifier
Brief Interventions in Chronic MigrainePeople with chronic migraine headaches face many challenges, including high levels of daily pain, disturbances to everyday activities and sleep, and problems with mood such as depression or anxiety. This trial is being completed to study whether changing an individual's behaviors may have an impact as a treatment for migraine headaches. Eligible participants will be randomized to one of the four arms. This study will be conducted remotely without in-person contact. Study Hypothesis: * There is a main effect of attending either the Empowered Relief and Health Education intervention on reductions in migraine-related disability 1 month after completing either intervention * There is a main effect of Empowered Relief and Health Education interventions on reducing pain-related catastrophizing and migraine symptom severity 1 month after completing either intervention (secondary hypothesis) * The expected reductions in migraine-related disability, pain catastrophizing, and migraine symptom severity will be maintained at secondary time points (2 months, 3 months, and 6 months after completing either intervention) (secondary hypothesis)	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Custom Mask InterfaceDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	NA	À vérifier	United States	À vérifier
Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord InjuryJust-In-Time Adaptive Interventions (JITAIs) offer a framework for delivering personalized behavioral support using time-varying data to optimize the timing and type of intervention content. This project will develop the foundational components of a JITAI tailored to adults with chronic pain and either MS or SCI by drawing on symptom self-management content from existing programs (PainGuide, MyMSToolkit, and MySCIToolkit). Intervention content and delivery parameters will be refined through stakeholder engagement via structured interviews to ensure relevance, acceptability, and feasibility.	SEP	À vérifier	Traitement symptomatique	United States	À vérifier
Discontinue antiseizure medicationsThe main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom. Physician guidelines endorse that after a period of seizure-freedom, the risk of another seizure may be low enough to allow patients to consider coming off antiseizure medication to see if they still need it. However, evidence is limited regarding how much continuing antiseizure medication still reduces seizures versus increases side effects after a patient has been treated for a while. This study will determine whether discontinuing antiseizure medications benefits patients.	Épilepsie	Phase 4	À vérifier	United States	À vérifier
Dynamic Standing DeskThis research is studying the use of a new type of standing desk in a small number of people to learn about the user experience for people with Parkinson's disease. 12 4-hour sessions will be performed to test the primary hypothesis that dynamic standing improves gait function compared to static standing and control sitting. This study has 2 phases. Phase 1 will be an open-label study and Phase 2 will be an in-lab randomized controlled trial pilot study. This is phase 1 of the study.	Parkinson	Phase 1	À vérifier	United States	À vérifier
ENHANCE — Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized EldersThe goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are the following: 1. To compare the effectiveness of FAM-HELP and HELP in reducing both the incidence of delirium and its severity. 2. To compare the effectiveness of FAM-HELP and HELP in improving patient- and family-reported outcomes. 3. To explore the implementation context, process, and outcomes of the FAM-HELP program in diverse hospital settings.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
HD-tDCS Active ProtocolThis study investigates whether unilateral and bilateral non-invasive brain stimulation, given for 20 minutes/once per day for twenty days (M-F) can reduce migraine pain. Fourty patients will receive treatment (20 unilateral treatment, and 20 bilateral treatment), while twenty will receive a "sham" procedure. Another 20 Episodic Migraine patients will be recruited for the observational aim of the study which does not include brain stimulation.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
HD-tDCS Sham ProtocolThis study investigates whether unilateral and bilateral non-invasive brain stimulation, given for 20 minutes/once per day for twenty days (M-F) can reduce migraine pain. Fourty patients will receive treatment (20 unilateral treatment, and 20 bilateral treatment), while twenty will receive a "sham" procedure. Another 20 Episodic Migraine patients will be recruited for the observational aim of the study which does not include brain stimulation.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
HD-tDCS treatmentsThis project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization activity, connectivity, and response to pain in healthy controls and age and sex-matched fibromyalgia patients; the third part (Aim 3) is a longitudinal assessment of fibromyalgia patients undergoing one week of sham followed by high-definition transcranial direct current stimulation (HD-tDCS) of the motor cortex (M1) or one week of ES HD-tDCS of a brain region identified from computer modelling (Aim 2).	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
Sham HD-tDCS treatmentsThis project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization activity, connectivity, and response to pain in healthy controls and age and sex-matched fibromyalgia patients; the third part (Aim 3) is a longitudinal assessment of fibromyalgia patients undergoing one week of sham followed by high-definition transcranial direct current stimulation (HD-tDCS) of the motor cortex (M1) or one week of ES HD-tDCS of a brain region identified from computer modelling (Aim 2).	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol PilotingThe goal of this study is to test efficacy and safety of person-centered, culturally-informed protocols for disclosure of different combinations of Alzheimer's dementia risk factors. Building on the results from a federally-funded assessment of preferences and needs of racially diverse participants and their respective friends/family members, in regard to Dementia - Alzheimer's Type (DAT), we have produced protocols for communication of DAT risk, with attention to specific adaptations in style or content based on individual factors and preferences. These protocols allow for communication of risk based on clinical history and diagnosis, structural neuroimaging, apolipoprotein-E status, and amyloid and tau burden on positron emission tomography. In particular, protocols specify (a) effective methods of communicating risk conferred by each data source, (b) information designed for patients versus informants, (c) psychoeducation needs, and (d) resource/support needs. We will recruit a randomly-selected subset of 10 dyads (including 5 participants who are Non-Hispanic African-American, 5 participants who are Non-Hispanic White) from the Stage I sample to whom we will develop and implement personalized DAT risk disclosure protocols. We will provide preliminary information on the effectiveness of these protocols in terms of patient/co-participant comprehension and recall of feedback provided, and initial changes in mood or behavior immediately following and shortly after risk disclosure sessions.	Alzheimer	NA	À vérifier	United States	À vérifier
SHARED III — Behavioral Change Following Alzheimer's Disease (AD) Biomarker DisclosureThe proposed project will assess long-term changes to health/lifestyle, advanced planning, and research engagement that Black and White patients with Amnestic Mild Cognitive Impairment (aMCI) make following disclosure of positron emission tomography-based amyloid and tau burden and associated risk of conversion to Dementia-Alzheimer's Type. Healthcare access will be explored as potential barrier to or facilitator of behavior change.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
Custom Mask InterfaceDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	NA	À vérifier	United States	À vérifier
Brain Computer Interface KeyboardThe purpose of this research is to develop tools enable people who are paralyzed to operate technology and access computers. These tools are called brain computer interfaces (BCIs). BCIs would let a person use brain signals to operate technology.	Sclérose latérale amyotrophique	Phase 1	À vérifier	United States	À vérifier
SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol PilotingThe goal of this study is to test efficacy and safety of person-centered, culturally-informed protocols for disclosure of different combinations of Alzheimer's dementia risk factors. Building on the results from a federally-funded assessment of preferences and needs of racially diverse participants and their respective friends/family members, in regard to Dementia - Alzheimer's Type (DAT), we have produced protocols for communication of DAT risk, with attention to specific adaptations in style or content based on individual factors and preferences. These protocols allow for communication of risk based on clinical history and diagnosis, structural neuroimaging, apolipoprotein-E status, and amyloid and tau burden on positron emission tomography. In particular, protocols specify (a) effective methods of communicating risk conferred by each data source, (b) information designed for patients versus informants, (c) psychoeducation needs, and (d) resource/support needs. We will recruit a randomly-selected subset of 10 dyads (including 5 participants who are Non-Hispanic African-American, 5 participants who are Non-Hispanic White) from the Stage I sample to whom we will develop and implement personalized DAT risk disclosure protocols. We will provide preliminary information on the effectiveness of these protocols in terms of patient/co-participant comprehension and recall of feedback provided, and initial changes in mood or behavior immediately following and shortly after risk disclosure sessions.	Alzheimer	NA	À vérifier	United States	À vérifier
Brief Interventions in Chronic MigrainePeople with chronic migraine headaches face many challenges, including high levels of daily pain, disturbances to everyday activities and sleep, and problems with mood such as depression or anxiety. This trial is being completed to study whether changing an individual's behaviors may have an impact as a treatment for migraine headaches. Eligible participants will be randomized to one of the four arms. This study will be conducted remotely without in-person contact. Study Hypothesis: * There is a main effect of attending either the Empowered Relief and Health Education intervention on reductions in migraine-related disability 1 month after completing either intervention * There is a main effect of Empowered Relief and Health Education interventions on reducing pain-related catastrophizing and migraine symptom severity 1 month after completing either intervention (secondary hypothesis) * The expected reductions in migraine-related disability, pain catastrophizing, and migraine symptom severity will be maintained at secondary time points (2 months, 3 months, and 6 months after completing either intervention) (secondary hypothesis)	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Discontinue antiseizure medicationsThe main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom. Physician guidelines endorse that after a period of seizure-freedom, the risk of another seizure may be low enough to allow patients to consider coming off antiseizure medication to see if they still need it. However, evidence is limited regarding how much continuing antiseizure medication still reduces seizures versus increases side effects after a patient has been treated for a while. This study will determine whether discontinuing antiseizure medications benefits patients.	Épilepsie	Phase 4	À vérifier	United States	À vérifier
HD-tDCS treatmentsThis project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization activity, connectivity, and response to pain in healthy controls and age and sex-matched fibromyalgia patients; the third part (Aim 3) is a longitudinal assessment of fibromyalgia patients undergoing one week of sham followed by high-definition transcranial direct current stimulation (HD-tDCS) of the motor cortex (M1) or one week of ES HD-tDCS of a brain region identified from computer modelling (Aim 2).	Myopathies	Non applicable	Traitement symptomatique	United States	À vérifier
Dynamic Standing DeskThis research is studying the use of a new type of standing desk in a small number of people to learn about the user experience for people with Parkinson's disease. 12 4-hour sessions will be performed to test the primary hypothesis that dynamic standing improves gait function compared to static standing and control sitting. This study has 2 phases. Phase 1 will be an open-label study and Phase 2 will be an in-lab randomized controlled trial pilot study. This is phase 1 of the study.	Parkinson	Phase 1	À vérifier	United States	À vérifier
SHARED III — Behavioral Change Following Alzheimer's Disease (AD) Biomarker DisclosureThe proposed project will assess long-term changes to health/lifestyle, advanced planning, and research engagement that Black and White patients with Amnestic Mild Cognitive Impairment (aMCI) make following disclosure of positron emission tomography-based amyloid and tau burden and associated risk of conversion to Dementia-Alzheimer's Type. Healthcare access will be explored as potential barrier to or facilitator of behavior change.	Alzheimer	Non applicable	À vérifier	United States	À vérifier
HD-tDCS Active ProtocolThis study investigates whether unilateral and bilateral non-invasive brain stimulation, given for 20 minutes/once per day for twenty days (M-F) can reduce migraine pain. Fourty patients will receive treatment (20 unilateral treatment, and 20 bilateral treatment), while twenty will receive a "sham" procedure. Another 20 Episodic Migraine patients will be recruited for the observational aim of the study which does not include brain stimulation.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord InjuryJust-In-Time Adaptive Interventions (JITAIs) offer a framework for delivering personalized behavioral support using time-varying data to optimize the timing and type of intervention content. This project will develop the foundational components of a JITAI tailored to adults with chronic pain and either MS or SCI by drawing on symptom self-management content from existing programs (PainGuide, MyMSToolkit, and MySCIToolkit). Intervention content and delivery parameters will be refined through stakeholder engagement via structured interviews to ensure relevance, acceptability, and feasibility.	SEP	À vérifier	Traitement symptomatique	United States	À vérifier
ENHANCE — Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized EldersThe goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are the following: 1. To compare the effectiveness of FAM-HELP and HELP in reducing both the incidence of delirium and its severity. 2. To compare the effectiveness of FAM-HELP and HELP in improving patient- and family-reported outcomes. 3. To explore the implementation context, process, and outcomes of the FAM-HELP program in diverse hospital settings.	Alzheimer	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
ENHANCE — Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders	Alzheimer	Non applicable	NCT05929703	ENHANCE — Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders	RECRUITING
Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord Injury	SEP	À vérifier	NCT07663266	Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord Injury	COMPLETED
HD-tDCS Active Protocol	Migraine	Non applicable	NCT05769348	Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)	RECRUITING
SHARED III — Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure	Alzheimer	Non applicable	NCT05584241	SHARED III — Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure	COMPLETED
Dynamic Standing Desk	Parkinson	Phase 1	NCT07543861	FOGSTAND — A Pilot Study of In-lab Dynamic Standing in Parkinson's Disease	RECRUITING
HD-tDCS treatments	Myopathies	Non applicable	NCT04606095	Explosive Synchronization of Brain Network Activity in Chronic Pain	ACTIVE_NOT_RECRUITING
Discontinue antiseizure medications	Épilepsie	Phase 4	NCT07750496	STOP-ASM — Outcomes After Planned Discontinuation of AntiSeizure Medication	RECRUITING
Brief Interventions in Chronic Migraine	Migraine	Non applicable	NCT05979337	Brief Interventions in Chronic Migraine	COMPLETED
SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting	Alzheimer	NA	NCT04309500	SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting	COMPLETED
Brain Computer Interface Keyboard	Sclérose latérale amyotrophique	Phase 1	NCT00860951	P300 Brain Computer Interface Keyboard to Operate Assistive Technology	COMPLETED
Custom Mask Interface	Sclérose latérale amyotrophique	NA	NCT03519880	A Pilot Study of the Utility of 3D Printed Masks for ALS Subjects	TERMINATED

Publications

Molécule	Titre	Journal
Discontinue antiseizure medications	Hypersensitivity reaction risk when restarting cenobamate after discontinuation: Insights from a prolonged hospitalized cohort.	Epilepsia open
Discontinue antiseizure medications	Ethosuximide-induced lupus erythematosus: Unveiling a rare adverse reaction through systematic review.	Epilepsy & behavior reports
Brain Computer Interface Keyboard	The ASME-speller: 30-class auditory brain-computer interface speller using stream segregation and the QWERTY layout.	Frontiers in human neuroscience
Custom Mask Interface	Actin Quantification Using the Filamentous Actin Segmentation Tool (FAST).	Bio-protocol
Custom Mask Interface	A cleanroom-free membrane-integrated organ-on-a-chip platform for rapid intestinal tissue formation.	Biofabrication
HD-tDCS treatments	A Randomized Controlled Trial of Dual Upper-Extremity Training [DUET]: Combining Neurologic Music Therapy® with Noninvasive Brain Stimulation for Upper-Limb Performance in Corticobasal Syndrome.	Movement disorders clinical practice
Brief Interventions in Chronic Migraine	Non-Pharmacological Treatment of Primary Headaches-A Focused Review.	Brain sciences
Brief Interventions in Chronic Migraine	Association of adverse childhood experiences with physical illness and self-rated health in the population-based Tromsø Study.	European journal of public health
Brain Computer Interface Keyboard	Long-term independent use of an intracortical brain-computer interface for speech and cursor control.	Nature medicine
Brain Computer Interface Keyboard	Noninvasive decoding of typed sentences from human brain activity.	Nature neuroscience
Custom Mask Interface	Prevalence and incidence of pressure injury in adult patients receiving non-invasive ventilation for acute respiratory failure: a systematic review protocol.	JBI evidence synthesis
Custom Mask Interface	Digitally Coded, Screen-Printed Flexible Metasurfaces for Tunable Electromagnetic Responses.	ACS applied materials & interfaces