University of Illinois at Chicago — Biomedical Watch V2

Traitements8programmes

Essais4liés

Publications3liées

SourceDBlocale

Traitements

8

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Analysis of Human ALS Tissues and Registry of ALS PatientsDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	À vérifier	Ralentissement de la progression	United States	À vérifier
FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MSThe goal of this clinical trial is to investigate the potential benefits of a specially designed exercise program for Hispanics/Latinos with multiple sclerosis (MS). The main questions it aims to answer are: * Can a 4-month remotely-delivered exercise training program improve physical function, symptom management, and quality of life in Hispanics/Latinos with MS? * How do social determinants of health, such as income, education, access to healthcare, and social support, influence the feasibility and effectiveness of the exercise intervention? Participants in this study will engage in a 4-month remotely-delivered exercise training intervention that includes flexibility, or aerobic and resistance exercise training sessions. They will work with experienced coaches who will guide and support them throughout the program. The researchers will compare the participants who receive the exercise intervention with a control group to see if the exercise program leads to significant improvements in physical function, fatigue, mood, and overall well-being for Hispanics/Latinos with MS. The study aims to empower this underserved population and provide insights for future healthcare and research initiatives.	SEP	Non applicable	Traitement symptomatique	United States	À vérifier
METS in MS — Exercise Training for Managing Major Depressive Disorder in Multiple SclerosisThe purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants. This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching program (FLEX-MS) for immediate and sustained reductions in the severity of depression among persons with MS who have MDD.	SEP	NA	À vérifier	United States	À vérifier
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and OlderThis is a multisite clinical trial of healthy lifestyle programs for middle-to-older-aged adults (50 -74 years) to improve their weight and, therefore, reduce risk for chronic disease. This study will investigate whether a proven, self-directed video-based lifestyle program can be significantly enhanced with the assistance of a coach via videoconference or phone to help people as they adopt healthy eating and exercise behaviors. Additionally, the study will examine what factors might explain why some people achieve better outcomes than others. Understanding this can help to tailor the program to an individual for personalized care in the future. Importantly, this study aims to demonstrate how readily a digital lifestyle program, with or without remote coaching, can be seamlessly delivered to patients at home via the patient portal of their electronic health record. This practical use of existing telehealth tools could be a feasible and effective means to offer behavioral treatments during routine medical care.	Hypertension	Non applicable	À vérifier	United States	À vérifier
METS in MS — Exercise Training for Managing Major Depressive Disorder in Multiple SclerosisThe purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants. This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching program (FLEX-MS) for immediate and sustained reductions in the severity of depression among persons with MS who have MDD.	SEP	NA	À vérifier	United States	À vérifier
FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MSThe goal of this clinical trial is to investigate the potential benefits of a specially designed exercise program for Hispanics/Latinos with multiple sclerosis (MS). The main questions it aims to answer are: * Can a 4-month remotely-delivered exercise training program improve physical function, symptom management, and quality of life in Hispanics/Latinos with MS? * How do social determinants of health, such as income, education, access to healthcare, and social support, influence the feasibility and effectiveness of the exercise intervention? Participants in this study will engage in a 4-month remotely-delivered exercise training intervention that includes flexibility, or aerobic and resistance exercise training sessions. They will work with experienced coaches who will guide and support them throughout the program. The researchers will compare the participants who receive the exercise intervention with a control group to see if the exercise program leads to significant improvements in physical function, fatigue, mood, and overall well-being for Hispanics/Latinos with MS. The study aims to empower this underserved population and provide insights for future healthcare and research initiatives.	SEP	Non applicable	Traitement symptomatique	United States	À vérifier
Analysis of Human ALS Tissues and Registry of ALS PatientsDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	À vérifier	Ralentissement de la progression	United States	À vérifier
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and OlderThis is a multisite clinical trial of healthy lifestyle programs for middle-to-older-aged adults (50 -74 years) to improve their weight and, therefore, reduce risk for chronic disease. This study will investigate whether a proven, self-directed video-based lifestyle program can be significantly enhanced with the assistance of a coach via videoconference or phone to help people as they adopt healthy eating and exercise behaviors. Additionally, the study will examine what factors might explain why some people achieve better outcomes than others. Understanding this can help to tailor the program to an individual for personalized care in the future. Importantly, this study aims to demonstrate how readily a digital lifestyle program, with or without remote coaching, can be seamlessly delivered to patients at home via the patient portal of their electronic health record. This practical use of existing telehealth tools could be a feasible and effective means to offer behavioral treatments during routine medical care.	Hypertension	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older	Hypertension	Non applicable	NCT05654142	The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older	ACTIVE_NOT_RECRUITING
Analysis of Human ALS Tissues and Registry of ALS Patients	Sclérose latérale amyotrophique	À vérifier	NCT05067179	Analysis of Human ALS Tissues and Registry of ALS Patients	RECRUITING
FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MS	SEP	Non applicable	NCT05998616	FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MS	TERMINATED
METS in MS — Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis	SEP	NA	NCT05051618	METS in MS — Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis	RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Analysis of Human ALS Tissues and Registry of ALS Patients		Global burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.	The Lancet. Infectious diseases
FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MS		Correction: Rationale for a 4-month, parallel-group, randomized controlled trial to assess the Feasibility and Efficacy of a Remotely delivered exercise training intervention for Hispanics/Latinos with Multiple Sclerosis (FERLA MS).	Pilot and feasibility studies
FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MS		Feasibility and preliminary outcomes of a remotely-delivered exercise training intervention for English-speaking Hispanics/Latinos with multiple sclerosis: Results from the FERLA MS study.	Multiple sclerosis journal - experimental, translational and clinical