Fiche société
University of Florida
Traitements, essais et publications liés.
Traitements15programmes
Essais8liés
Publications23liées
SourceDBlocale
Traitements
15| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Active biphasic pulse stimulation---Home SettingsThis project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices. The study team aims to investigate safety and efficacy of these new stimulation parameters in patients with ET. | Parkinson | Non applicable | À vérifier | United States | À vérifier |
| Active biphasic pulse stimulation---Stimulator OffThis project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices. The study team aims to investigate safety and efficacy of these new stimulation parameters in patients with ET. | Parkinson | Non applicable | À vérifier | United States | À vérifier |
| Active biphasic pulse stimulation---VIN BiphasicThis project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices. The study team aims to investigate safety and efficacy of these new stimulation parameters in patients with ET. | Parkinson | Non applicable | À vérifier | United States | À vérifier |
| AIDP — Automated Imaging Differentiation of ParkinsonismThe purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis. | Parkinson | À vérifier | À vérifier | United States, Canada | À vérifier |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy PatientsThis pilot study will investigate the potential efficacy of VM100, a nutritional supplement specifically formulated for patients with DMD, on quality of life and physical symptoms. Twenty patients (aged 8 an over) will be enrolled to undergo a 10-week placebo-controlled intervention with VM100. Outcomes will include validated questionnaires and qualitative interview to assess impact on mental, cognitive and mood related measures, as well as endurance and fatigue). | Myopathies | Non applicable | Traitement symptomatique | United States | À vérifier |
| MetforminThe goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures. The main question it aims to answer is: * Does metformin have beneficial effect on epileptic patients? * How metformin can affect epileptic patient's health? Participants will be divided into 2 groups (control group and treatment group) * Control group will receive standard treatment (levetiracetam \&/or sodium valproate). * Treatment group will receive standard treatment (levetiracetam \&/or sodium valproate) + metformin | Cancer, Épilepsie, Myopathies, Sclérose latérale amyotrophique | Phase 2 | À vérifier | United States | À vérifier |
| TadalafilExamining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatment. | Myopathies | Phase 2 | À vérifier | United States | À vérifier |
| TadalafilExamining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatment. | Myopathies | Phase 2 | À vérifier | United States | À vérifier |
| TadalafilExamining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatment. | Myopathies | Phase 2 | À vérifier | United States | À vérifier |
| MetforminThe goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures. The main question it aims to answer is: * Does metformin have beneficial effect on epileptic patients? * How metformin can affect epileptic patient's health? Participants will be divided into 2 groups (control group and treatment group) * Control group will receive standard treatment (levetiracetam \&/or sodium valproate). * Treatment group will receive standard treatment (levetiracetam \&/or sodium valproate) + metformin | Cancer | Phase 1 | À vérifier | United States | À vérifier |
| AIDP — Automated Imaging Differentiation of ParkinsonismThe purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis. | Parkinson | À vérifier | À vérifier | United States, Canada | À vérifier |
| MetforminThe goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures. The main question it aims to answer is: * Does metformin have beneficial effect on epileptic patients? * How metformin can affect epileptic patient's health? Participants will be divided into 2 groups (control group and treatment group) * Control group will receive standard treatment (levetiracetam \&/or sodium valproate). * Treatment group will receive standard treatment (levetiracetam \&/or sodium valproate) + metformin | Myopathies | Non applicable | À vérifier | Belgium | À vérifier |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy PatientsThis pilot study will investigate the potential efficacy of VM100, a nutritional supplement specifically formulated for patients with DMD, on quality of life and physical symptoms. Twenty patients (aged 8 an over) will be enrolled to undergo a 10-week placebo-controlled intervention with VM100. Outcomes will include validated questionnaires and qualitative interview to assess impact on mental, cognitive and mood related measures, as well as endurance and fatigue). | Myopathies | Non applicable | Traitement symptomatique | United States | À vérifier |
| MetforminThe goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures. The main question it aims to answer is: * Does metformin have beneficial effect on epileptic patients? * How metformin can affect epileptic patient's health? Participants will be divided into 2 groups (control group and treatment group) * Control group will receive standard treatment (levetiracetam \&/or sodium valproate). * Treatment group will receive standard treatment (levetiracetam \&/or sodium valproate) + metformin | Sclérose latérale amyotrophique | Phase 2 | À vérifier | United States | À vérifier |
| Active biphasic pulse stimulation---Home SettingsThis project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices. The study team aims to investigate safety and efficacy of these new stimulation parameters in patients with ET. | Parkinson | Non applicable | À vérifier | United States | À vérifier |
Essais cliniques
8| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Active biphasic pulse stimulation---Home Settings | Parkinson | Non applicable | NCT03811405 | Physiology, Imaging and Modeling of Essential Tremor | COMPLETED |
| Metformin | Sclérose latérale amyotrophique | Phase 2 | NCT04220021 | Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD | ACTIVE_NOT_RECRUITING |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients | Myopathies | Non applicable | NCT07766980 | Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients | RECRUITING |
| Metformin | Myopathies | Non applicable | NCT00720161 | Metformin in Children With Motor Deficit | COMPLETED |
| AIDP — Automated Imaging Differentiation of Parkinsonism | Parkinson | À vérifier | NCT05913687 | AIDP — Automated Imaging Differentiation of Parkinsonism | ACTIVE_NOT_RECRUITING |
| Metformin | Cancer | Phase 1 | NCT06044025 | A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy | RECRUITING |
| Tadalafil | Myopathies | Phase 2 | NCT05195775 | Tadalafil as Adjuvant Therapy for DMD | ACTIVE_NOT_RECRUITING |
| Tadalafil | Myopathies | Phase 2 | NCT06290713 | Vasodilator and Exercise Study for DMD (VASO-REx) | RECRUITING |
Publications
23| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Tadalafil | Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS). | The aging male : the official journal of the International Society for the Study of the Aging Male | ||
| Tadalafil | Real-world outcomes of tadalafil plus mirabegron combination therapy in men with lower urinary tract symptoms and overactive bladder symptoms: a retrospective cohort study. | The aging male : the official journal of the International Society for the Study of the Aging Male | ||
| Metformin | Metformin added to lifestyle intervention for physical function in older adults with obesity (DEMFOS trial): a randomised controlled trial. | The lancet. Healthy longevity | ||
| Metformin | Adjunctive metformin for obesity and frailty in older people-puncturing inflated expectations? | The lancet. Healthy longevity | ||
| Tadalafil | Risk of glaucoma among patients using tadalafil for lower urinary tract symptoms: a multinational cohort study. | The British journal of ophthalmology | ||
| Metformin | Metformin Attenuates Sepsis-Induced Cardiomyopathy via Inhibition of Reverse Electron Transfer at Mitochondrial Complex I. | Biology | ||
| Metformin | Time to Insulin Initiation Among Patients With Type 2 Diabetes Treated With Second-Line Antidiabetic Drugs. | Diabetes, obesity & metabolism | ||
| Metformin | SIRT1 in brain aging: molecular mechanisms and therapeutic potential of pharmacological and natural modulators. | Biogerontology | ||
| Metformin | Metformin enhances hippocampal excitatory synaptic transmission and preserves synaptic plasticity under amyloid-β oligomer-induced dysfunction. | Neuropharmacology | ||
| Metformin | Diabetic Patients With Newly Diagnosed Chronic Myeloid Leukemia: TKI Choice and Early Adverse Events. A Real-Life Survey Within the Italian Chronic Myeloid Leukemia Network. | European journal of haematology | ||
| Metformin | Case Report: Early-onset euglycemic diabetic ketoacidosis following henagliflozin initiation in a treatment-naive patient. | Frontiers in endocrinology | ||
| Metformin | Beyond intraocular pressure: vascular and metabolic modifiers of optic nerve vulnerability in glaucoma. | International ophthalmology | ||
| Tadalafil | Targeting canonical TGFβ/SMAD3 and ERK1/2 signaling in human valve interstitial cells to modulate immune-fibrotic responses in rheumatic heart disease. | Journal of physiology and biochemistry | ||
| Tadalafil | Erectile dysfunction severity and penile Doppler findings in pelvic fracture urethral injury: A descriptive cohort study. | Indian journal of urology : IJU : journal of the Urological Society of India | ||
| Metformin | High Volume Hemofiltration : what are the last indications in 2026 - a narrative review. | Blood purification | ||
| Metformin | BAIBA attenuates pulmonary fibrosis by modulating the iron/ROS-mitochondrion-apoptosis cascade. | Free radical biology & medicine | ||
| Metformin | Evaluation of insulin, leptin, ghrelin, and adiponectin levels in type 2 diabetic patients receiving combined metformin-sulfonylurea therapy. | Biomeditsinskaia khimiia | ||
| Metformin | The efficacy of intermittent metformin plus lifestyle intervention for diabetes prevention in women with prediabetes and prior gestational diabetes: a randomized clinical, non-inferiority trial. | BMC medicine | ||
| Metformin | S2P-modified PLGA bifunctional nanodrug: inhibiting vascular senescence and foam cell formation for atherosclerosis treatment. | Journal of nanobiotechnology | ||
| Metformin | Medicolegal autopsy reconstruction of a medication-related adverse event trajectory in a psychiatric inpatient with diabetes: a case report. | Journal of medical case reports | ||
| Metformin | Corrigendum to "Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation" [J Orthop Transl 46 (2024) 129-142]. | Journal of orthopaedic translation | ||
| Tadalafil | Selective targeting phosphodiesterase-5 (PDE5): clinical progress, design strategies, and emerging prospects. | Journal of enzyme inhibition and medicinal chemistry | ||
| Tadalafil | PDE5A variation is associated with tadalafil response in men with diabetes mellitus and erectile dysfunction: a prospective proof-of-concept pharmacogenetic study. | The journal of sexual medicine |