Fiche société
University of Chicago
Traitements, essais et publications liés.
Traitements11programmes
Essais6liés
Publications31liées
SourceDBlocale
Traitements
11| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| CRx-D — CommunityRx-DementiaCaregivers of home-dwelling people with Alzheimer's Disease and related dementias (ADRD) are one of the most rapidly growing populations in the United States. Among ADRD caregivers with unmet health-related social needs, this study aims to evaluate the effects of the CRx-D intervention versus usual care on caregiver self-efficacy. | Alzheimer | Non applicable | À vérifier | United States | À vérifier |
| fenfluramine HClThis study plans to learn if certain markers found during electroencephalogram (EEG) analysis could predict fenfluramine responsiveness to give clinicians greater insight into the effectiveness of fenfluramine in people with Lennox Gastaut Syndrome (LGS). | Épilepsie | À vérifier | À vérifier | United States | À vérifier |
| hydroxyureaThis phase II trial studies nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation) and carboplatin followed by response-based local therapy in treating patients with stage III or IV human papillomavirus (HPV)-related oropharyngeal cancer. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, carboplatin, hydroxyurea, fluorouracil, paclitaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them spreading. Radiation therapy uses high energy x rays to kill tumor cells. Giving nab-paclitaxel and carboplatin before chemoradiation may make the tumor smaller and reduce the amount of chemotherapy and radiation therapy needed. Assigning chemotherapy and radiation therapy based on response (response-based therapy) and giving patients who are responding well lower doses of treatment may help reduce the occurrence of side effects. | Cancer | Phase 2 | À vérifier | United States | À vérifier |
| Mobile Health Management of HypertensionThe investigators will pilot test a hypertension self-management intervention for feasibility and acceptability. The investigators will enroll adults (age ≥18) with uncontrolled hypertension, identified from the electronic health record. In this feasibility trial, the research aim is to explore trial design, participant acceptability of the intervention and outcome measures, and to generate data to inform the design of a future randomized controlled trial. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| paclitaxel albumin-stabilized nanoparticle formulationThis phase II trial studies nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation) and carboplatin followed by response-based local therapy in treating patients with stage III or IV human papillomavirus (HPV)-related oropharyngeal cancer. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, carboplatin, hydroxyurea, fluorouracil, paclitaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them spreading. Radiation therapy uses high energy x rays to kill tumor cells. Giving nab-paclitaxel and carboplatin before chemoradiation may make the tumor smaller and reduce the amount of chemotherapy and radiation therapy needed. Assigning chemotherapy and radiation therapy based on response (response-based therapy) and giving patients who are responding well lower doses of treatment may help reduce the occurrence of side effects. | Cancer | Phase 2 | À vérifier | United States | À vérifier |
| VIDA — Virtual Diabetes Group Visits Across Health SystemsThe purpose of this project is to evaluate the effectiveness of a virtual diabetes group visits on patients with type 2 diabetes mellitus (T2DM). | Hypertension | NA | À vérifier | United States | À vérifier |
| paclitaxel albumin-stabilized nanoparticle formulationThis phase II trial studies nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation) and carboplatin followed by response-based local therapy in treating patients with stage III or IV human papillomavirus (HPV)-related oropharyngeal cancer. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, carboplatin, hydroxyurea, fluorouracil, paclitaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them spreading. Radiation therapy uses high energy x rays to kill tumor cells. Giving nab-paclitaxel and carboplatin before chemoradiation may make the tumor smaller and reduce the amount of chemotherapy and radiation therapy needed. Assigning chemotherapy and radiation therapy based on response (response-based therapy) and giving patients who are responding well lower doses of treatment may help reduce the occurrence of side effects. | Cancer | Phase 2 | À vérifier | United States | À vérifier |
| VIDA — Virtual Diabetes Group Visits Across Health SystemsThe purpose of this project is to evaluate the effectiveness of a virtual diabetes group visits on patients with type 2 diabetes mellitus (T2DM). | Hypertension | NA | À vérifier | United States | À vérifier |
| fenfluramine HClThis study plans to learn if certain markers found during electroencephalogram (EEG) analysis could predict fenfluramine responsiveness to give clinicians greater insight into the effectiveness of fenfluramine in people with Lennox Gastaut Syndrome (LGS). | Épilepsie | À vérifier | À vérifier | United States | À vérifier |
| CRx-D — CommunityRx-DementiaCaregivers of home-dwelling people with Alzheimer's Disease and related dementias (ADRD) are one of the most rapidly growing populations in the United States. Among ADRD caregivers with unmet health-related social needs, this study aims to evaluate the effects of the CRx-D intervention versus usual care on caregiver self-efficacy. | Alzheimer | Non applicable | À vérifier | United States | À vérifier |
| Mobile Health Management of HypertensionThe investigators will pilot test a hypertension self-management intervention for feasibility and acceptability. The investigators will enroll adults (age ≥18) with uncontrolled hypertension, identified from the electronic health record. In this feasibility trial, the research aim is to explore trial design, participant acceptability of the intervention and outcome measures, and to generate data to inform the design of a future randomized controlled trial. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
Essais cliniques
6| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Mobile Health Management of Hypertension | Hypertension | Non applicable | NCT05856955 | Mobile Health Management of Hypertension | NOT_YET_RECRUITING |
| CRx-D — CommunityRx-Dementia | Alzheimer | Non applicable | NCT04146545 | CRx-D — CommunityRx-Dementia | COMPLETED |
| fenfluramine HCl | Épilepsie | À vérifier | NCT07555171 | EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine Treatment | ENROLLING_BY_INVITATION |
| Alemtuzumab | SEP | Phase 4 | NCT01395316 | Alemtuzumab on Surrogate Markers of Disease Activity and Repair Using Advanced MRI Measures in Subjects With Relapsing Remitting Multiple Sclerosis | COMPLETED |
| VIDA — Virtual Diabetes Group Visits Across Health Systems | Hypertension | NA | NCT06094491 | VIDA — Virtual Diabetes Group Visits Across Health Systems | ACTIVE_NOT_RECRUITING |
| paclitaxel albumin-stabilized nanoparticle formulation | Cancer | Phase 2 | NCT02258659 | Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal Cancer | COMPLETED |
Publications
31| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| fenfluramine HCl | A pilot, open-label study of the effectiveness and tolerability of low-dose ZX008 (fenfluramine HCl) in Lennox-Gastaut syndrome. | Epilepsia | ||
| fenfluramine HCl | A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects . | International journal of clinical pharmacology and therapeutics | ||
| fenfluramine HCl | Fenfluramine HCl (Fintepla ) provides long-term clinically meaningful reduction in seizure frequency: Analysis of an ongoing open-label extension study. | Epilepsia | ||
| hydroxyurea | Thrombotic burden and longitudinal outcomes in Thai patients with polycythemia vera. | Annals of medicine | ||
| hydroxyurea | Tubular dysfunction in stable adult sickle cell patients in Kinshasa: prevalence and associated factors - a cross-sectional study. | Renal failure | ||
| hydroxyurea | Distinct clinical, molecular, and treatment response profiles in primary and secondary myelofibrosis: a single-center retrospective study. | Hematology (Amsterdam, Netherlands) | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Ivonescimab combined with chemotherapy for the treatment of metastatic cervical cancer: A case report and literature review. | Human vaccines & immunotherapeutics | ||
| paclitaxel albumin-stabilized nanoparticle formulation | The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity. | Drug delivery | ||
| Mobile Health Management of Hypertension | AQbD-guided development of a robust and green SI-RP-HPLC method for impurity profiling of an efonidipine hydrochloride ethanolate and chlorthalidone combination, with LC-MS and NMR-based identification of degradation product in efonidipine. | Journal of chromatography. A | ||
| Mobile Health Management of Hypertension | Health system competence and care continuity in patients with hypertension: electronic cohort in Uruguay. | Blood pressure | ||
| Mobile Health Management of Hypertension | From clinic to home monitoring: Diagnostic strategies and evidence landscape of white-coat uncontrolled hypertension. | Clinical and experimental hypertension (New York, N.Y. : 1993) | ||
| hydroxyurea | Evaluation of The Use of Hydroxyurea in Treating Children With Sickle Cell Anemia in Central Africa's Rural Area. | EJHaem | ||
| hydroxyurea | Mechanisms of Hydroxyurea-Mediated DNA Damage Potentiation in Fanconi Anemia Cells. | International journal of molecular sciences | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Efficacy and Safety of Sintilimab in Combination With Anlotinib and Chemoradiotherapy as First-Line Treatment for Driver Gene-Negative Oligometastatic Non-small Cell Lung Cancer: A Real-World Cohort Study. | Dose-response : a publication of International Hormesis Society | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Prospective evaluation of dynamic changes in L3 skeletal muscle index and chemotherapy-induced peripheral neuropathy during albumin-bound paclitaxel chemotherapy. | Frontiers in oncology | ||
| VIDA — Virtual Diabetes Group Visits Across Health Systems | Implementing virtual diabetes self-management education in two health systems (VIDA): a mixed-methods pilot study. | Frontiers in clinical diabetes and healthcare | ||
| hydroxyurea | Cross-study analyses of the ropeginterferon alfa-2b effect on phlebotomy in low- and high-risk patients with polycythemia vera. | Leukemia & lymphoma | ||
| hydroxyurea | Hepatobiliary Abnormalities in Children With Sickle Cell Anemia Attending a Tertiary Hospital in Northwestern Tanzania. | Journal of pediatric hematology/oncology | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Treatment Sequencing in Platinum-Resistant Epithelial Ovarian Cancer After MIRASOL, KEYNOTE-B96, and ROSELLA. | International journal of women's health | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Clinicopathological and molecular characteristics of primary pulmonary choriocarcinoma: a case report and systematic review. | Frontiers in oncology | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Neoadjuvant nedaplatin and paclitaxel regimen with concurrent radiotherapy for esophageal squamous cell carcinoma: a single-arm phase II clinical trial. | Future oncology (London, England) | ||
| hydroxyurea | Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia. | European journal of haematology | ||
| hydroxyurea | Treating a patient with ADP porphyria through suppression of both hepatic and erythroid ALA production. | Orphanet journal of rare diseases | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Albumin-Based Drug Delivery for Glioblastoma Treatment: Mechanistic Rationale, Preclinical Evidence, and Clinical Translation. | Cells | ||
| paclitaxel albumin-stabilized nanoparticle formulation | A young pregnant woman with oesophageal cancer who responded to carboplatin plus nab-paclitaxel therapy. | Clinical journal of gastroenterology | ||
| hydroxyurea | S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancers. | Cell death and differentiation | ||
| hydroxyurea | Cancer history and second cancer risk in polycythemia vera and essential thrombocythemia. | Blood cancer journal | ||
| hydroxyurea | Enigmatic Case of Adult-Onset Langerhans Cell Histiocytosis with Aggressive Bony Involvement. | Journal of Brown hospital medicine | ||
| hydroxyurea | Hydroxyurea Promotes Brain Development in Children with Sickle Cell Anemia. | Brain research bulletin | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Association Between Geriatric Nutritional Risk Index and Gemcitabine Plus Nab-Paclitaxel Continuation in Elderly Patients With Pancreatic Cancer. | Anticancer research | ||
| paclitaxel albumin-stabilized nanoparticle formulation | Nab-paclitaxel or Paclitaxel Treatment for Relapsed Small Cell Lung Cancer: A Single-arm Meta-analysis. | Anticancer research |