University of Arkansas — Biomedical Watch V2

Traitements3programmes

Essais2liés

Publications7liées

SourceDBlocale

Traitements

3

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
RFA ApplicatorThe purpose of this study is to build a device that will consistently ablate (destroy or remove) cavitary breast tissue after a formal breast cancer resection in order to mimic the tissue that is now irradiated after breast cancer lumpectomy. The device would be easier to handle, perform the ablation in less time and by so ablating this margin would avoid the need in many for reoperation to obtain negative margins and based on preliminary data avoid the need for radiation. This would be especially important in poor and rural patients and would lead to decreased costs of treatment in patients with favorable breast cancer.	Cancer	Non applicable	À vérifier	United States	À vérifier
TurmericThe goal of this clinical trial is to assess the feasibility of adding a combination of metformin and turmeric as part of a nutritional intervention regimen to the current standard of care, namely, intermittent Androgen Deprivation Therapy (iADT), for patients with castration sensitive biochemical progressive prostate cancer. The main objectives are: * Assess the feasibility of the study population and enrollment. * Evaluate time to PSA relapse with nutritional intervention on iADT. Participants who are receiving iADT will be dispensed Metformin and turmeric and complete a pill diary. Participants will also have blood and stool samples collected and complete quality of life questionnaires. The long-term goal is to further assess the efficacy and safety of this nutritional regimen and the roles of metabolic syndrome, microenvironment/microbiome, and genomic vs epigenomic profiles in the care of these patients through a clinical trial.	Cancer	Phase 1	À vérifier	United States	À vérifier
RFA ApplicatorThe purpose of this study is to build a device that will consistently ablate (destroy or remove) cavitary breast tissue after a formal breast cancer resection in order to mimic the tissue that is now irradiated after breast cancer lumpectomy. The device would be easier to handle, perform the ablation in less time and by so ablating this margin would avoid the need in many for reoperation to obtain negative margins and based on preliminary data avoid the need for radiation. This would be especially important in poor and rural patients and would lead to decreased costs of treatment in patients with favorable breast cancer.	Cancer	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
RFA Applicator	Cancer	Non applicable	NCT02525913	Feasibility Study of Cavity Radiofrequency Ablation in ex Vivo Mastectomy Breast Tissue	WITHDRAWN
Metformin	Cancer	Phase 1	NCT06044025	A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy	RECRUITING

Publications

7

Molécule	Indication / population	Titre	Journal	Date
Turmeric		Low, plasma level‑informed native curcumin concentrations fail to induce cell death in human lung and colorectal cancer cells.	Pharmaceutical biology
Turmeric		Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP.	Pharmaceutical biology
Turmeric		Optimal dose window, formulation efficacy, and molecular mechanisms of curcumin in MASLD animal models: A systematic review and three-level meta-analysis.	Journal of ethnopharmacology
Turmeric		Hydrophobic Deep Eutectic Solvent-Derived Curcuminoids Loaded into a Double-Layer Colloidal Delivery System: Physicochemical Properties and In Vitro Biological Activity.	Foods (Basel, Switzerland)
Turmeric		Enhanced Oral Delivery of Turmeric Extract via Spray-Dried Microparticles: Biopharmaceutical Performance and In Vitro Microbiota Modulation.	International journal of molecular sciences
Turmeric		Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism.	Translational neurodegeneration
Turmeric		Turmeric-derived mesoporous carbon as a bioactive material: In vitro anticancer, antidiabetic, and anti-inflammatory evaluation.	Bioorganic chemistry