Fiche société
University of Aarhus
Traitements, essais et publications liés.
Traitements15programmes
Essais7liés
Publications13liées
SourceDBlocale
Traitements
15| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Active drug for acute migraine treatmentThe study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, advanced balanced placebo design, patients with episodic migraine will receive six treatment conditions in a randomized order. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Active drug for chronic migraine treatment.The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, balanced placebo design, patients with chronic migraine will receive four treatment conditions in a randomized order. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| CoSHEDRMS — Comparative Study of High-Efficacy Disease Modifying Treatment of Relapsing Multiple SclerosisThe goal of this prospective, multi-center, non-blinded, non-randomized, non-intervention clinical trial is to compare immunologic, virologic and epigenetic factors in patients with active multiple sclerosis in standard 2.line treatment with ocrelizumab, rituximab, ofatumumab or natalizumab in Region Midt, Denmark. It aims to answer how the immunologic, virologic and epigenetic response in these patients are compared to healthy controls, and analyze their treatment effect in relation to this response. Participants will get an extra blood sample, when they have their routine blood samples taken. | SEP | Non applicable | À vérifier | Denmark | À vérifier |
| Laser speckle contrast imagingThis multicentre feasibility study evaluates the feasibility of performing laparoscopic Laser Speckle Contrast Imaging (LSCI) measurements of rectal perfusion during rectal cancer surgery. To our knowledge, LSCI has not previously been applied laparoscopically for intraoperative assessment of rectal perfusion in this setting. Laparoscopic LSCI measurements will be compared with indocyanine green fluorescence imaging, and associations between quantitative measures of colorectal perfusion and postoperative outcomes, including anastomotic leakage, will be explored. | Cancer | Non applicable | À vérifier | Denmark | À vérifier |
| Photon therapyThe purpose of this study is to assess late gastro-intestinal side-effects comparing proton therapy to photon therapy in high-risk prostate cancer patients receiving whole pelvic irradiation. | Cancer | Non applicable | À vérifier | Denmark | À vérifier |
| Proton therapyThe purpose of this study is to assess late gastro-intestinal side-effects comparing proton therapy to photon therapy in high-risk prostate cancer patients receiving whole pelvic irradiation. | Cancer | Non applicable | À vérifier | Denmark | À vérifier |
| Systematic exercise trainingThis study seeks to investigate whether early exercise efforts can expand the use of exercise in Multiple sclerosis (MS), from symptom treatment only, to early supplementary disease-modifying treatment. The study will be conducted in a randomized and controlled manner, with single blinding. Participants will be allocated to either a systematic aerobic exercise intervention or an educational programme on exercise and physical activity. Both interventions will last 1 year, and involve a 1 year follow-up period. It is hypothesized that early exercise efforts can modify the disease activity and disability progression. | SEP | NA | Ralentissement de la progression | Denmark | À vérifier |
| Validity and Reliability of VO2-max Measurements in Persons With Parkinson's DiseaseEach participant would complete four test days and each test day is separated by 7-10 days. At each test day the participants would complete a graded maximal exercise test (VO2max-test), a chair rise (Linear encoder) as well as measuring of basic demographic outcomes (weight, fat%,blood pressure etc.). The first test day would further include a motor (MDS-UPDRS III) and cognitive examination (MoCA), a questionnaire about quality of life (PDQ-39) and one about depression (BDI-II). Furthermore, the first test day would include two test of walking performance (6 minutes walk test and Time Up and Go). Two of the test days would be completed while the participants are off their Parkinson disease medication for at least 12 hours, while the other two test days would be completed while on their Parkinson medication. The order of the tests would be randomized. It is hypothesized that the VO2max test would be reliable and valid when participants are on medication, while off-medication would affect the reliability and validity. | Parkinson | À vérifier | À vérifier | Denmark | À vérifier |
| Systematic exercise trainingThis study seeks to investigate whether early exercise efforts can expand the use of exercise in Multiple sclerosis (MS), from symptom treatment only, to early supplementary disease-modifying treatment. The study will be conducted in a randomized and controlled manner, with single blinding. Participants will be allocated to either a systematic aerobic exercise intervention or an educational programme on exercise and physical activity. Both interventions will last 1 year, and involve a 1 year follow-up period. It is hypothesized that early exercise efforts can modify the disease activity and disability progression. | SEP | NA | Ralentissement de la progression | Denmark | À vérifier |
| Validity and Reliability of VO2-max Measurements in Persons With Parkinson's DiseaseEach participant would complete four test days and each test day is separated by 7-10 days. At each test day the participants would complete a graded maximal exercise test (VO2max-test), a chair rise (Linear encoder) as well as measuring of basic demographic outcomes (weight, fat%,blood pressure etc.). The first test day would further include a motor (MDS-UPDRS III) and cognitive examination (MoCA), a questionnaire about quality of life (PDQ-39) and one about depression (BDI-II). Furthermore, the first test day would include two test of walking performance (6 minutes walk test and Time Up and Go). Two of the test days would be completed while the participants are off their Parkinson disease medication for at least 12 hours, while the other two test days would be completed while on their Parkinson medication. The order of the tests would be randomized. It is hypothesized that the VO2max test would be reliable and valid when participants are on medication, while off-medication would affect the reliability and validity. | Parkinson | À vérifier | À vérifier | Denmark | À vérifier |
| Active drug for acute migraine treatmentThe study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, advanced balanced placebo design, patients with episodic migraine will receive six treatment conditions in a randomized order. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Active drug for chronic migraine treatment.The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, balanced placebo design, patients with chronic migraine will receive four treatment conditions in a randomized order. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Proton therapyThe purpose of this study is to assess late gastro-intestinal side-effects comparing proton therapy to photon therapy in high-risk prostate cancer patients receiving whole pelvic irradiation. | Cancer | Non applicable | À vérifier | Denmark | À vérifier |
| CoSHEDRMS — Comparative Study of High-Efficacy Disease Modifying Treatment of Relapsing Multiple SclerosisThe goal of this prospective, multi-center, non-blinded, non-randomized, non-intervention clinical trial is to compare immunologic, virologic and epigenetic factors in patients with active multiple sclerosis in standard 2.line treatment with ocrelizumab, rituximab, ofatumumab or natalizumab in Region Midt, Denmark. It aims to answer how the immunologic, virologic and epigenetic response in these patients are compared to healthy controls, and analyze their treatment effect in relation to this response. Participants will get an extra blood sample, when they have their routine blood samples taken. | SEP | Non applicable | À vérifier | Denmark | À vérifier |
| Laser speckle contrast imagingThis multicentre feasibility study evaluates the feasibility of performing laparoscopic Laser Speckle Contrast Imaging (LSCI) measurements of rectal perfusion during rectal cancer surgery. To our knowledge, LSCI has not previously been applied laparoscopically for intraoperative assessment of rectal perfusion in this setting. Laparoscopic LSCI measurements will be compared with indocyanine green fluorescence imaging, and associations between quantitative measures of colorectal perfusion and postoperative outcomes, including anastomotic leakage, will be explored. | Cancer | Non applicable | À vérifier | Denmark | À vérifier |
Essais cliniques
7| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Laser speckle contrast imaging | Cancer | Non applicable | NCT07799740 | LIRA — Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging | NOT_YET_RECRUITING |
| CoSHEDRMS — Comparative Study of High-Efficacy Disease Modifying Treatment of Relapsing Multiple Sclerosis | SEP | Non applicable | NCT06159712 | CoSHEDRMS — Comparative Study of High-Efficacy Disease Modifying Treatment of Relapsing Multiple Sclerosis | UNKNOWN |
| Proton therapy | Cancer | Non applicable | NCT05350475 | Protons vs. Photons for High-risk Prostate Cancer | ACTIVE_NOT_RECRUITING |
| Active drug for chronic migraine treatment. | Migraine | Non applicable | NCT07071506 | New Methods for Evaluating Preventive Migraine Treatment | RECRUITING |
| Active drug for acute migraine treatment | Migraine | Non applicable | NCT06617832 | Trial Designs for Evaluating Migraine Treatment | RECRUITING |
| Validity and Reliability of VO2-max Measurements in Persons With Parkinson's Disease | Parkinson | À vérifier | NCT05127031 | Validity and Reliability of VO2-max Measurements in Persons With Parkinson's Disease | COMPLETED |
| Systematic exercise training | SEP | NA | NCT03322761 | Early Exercise Efforts in Multiple Sclerosis | COMPLETED |
Publications
13| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Active drug for chronic migraine treatment. | Migraine relief: Solutions from natural bioactive products of Traditional Chinese medicine. | Journal of ethnopharmacology | ||
| Active drug for chronic migraine treatment. | Xiongzhi Qufeng Zhitong Granule alleviates nitroglycerin-induced migraine-like nociception and central neuroinflammation by regulating the HMGB1 / TRPV1 / MAPK signaling axis. | Journal of ethnopharmacology | ||
| Active drug for chronic migraine treatment. | Paeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucleus caudalis neuroinflammation in chronic migraine associated with P2Y12R/PPARγ-related NF-κB signaling. | Journal of ethnopharmacology | ||
| Active drug for acute migraine treatment | Ginger for the treatment and prevention of migraine headaches: a systematic review and meta-analysis of randomised controlled trials. | BMJ evidence-based medicine | ||
| Active drug for acute migraine treatment | NOP receptor activation counteracts stress-induced migraine-like behaviors in mice. | Neuropharmacology | ||
| Photon therapy | Acute radiation side effects of proton versus photon therapy following surgery for early breast cancer, a sub-study of the randomised controlled DBCG Proton Trial. | International journal of radiation oncology, biology, physics | ||
| Photon therapy | The Evolution of Radiotherapy in Children's Oncology Group Trials, from 1998-2025. | International journal of radiation oncology, biology, physics | ||
| Photon therapy | Time series analysis for optimal offline replanning timing in head and neck proton therapy. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | ||
| Proton therapy | Etiology-guided mutational signature learning from DNA repair knockouts in cell lines using supervised NMF. | NAR genomics and bioinformatics | ||
| Proton therapy | Clinical Comparison of Beam-Specific Planning Target Volume Single-Field Uniform Dose and Robust Intensity-Modulated Proton Therapy in Ultra-Hypofractionation for Prostate Cancer. | International journal of particle therapy | ||
| Proton therapy | Patient-Specific Deep Reinforcement Learning for Proton Beam Delivery Under Inter-Phase Variations. | International journal of particle therapy | ||
| Systematic exercise training | The angiotensin-converting enzyme I/D polymorphism does not impact training-induced adaptations in exercise capacity in patients with stable coronary artery disease. | Scientific reports | ||
| Systematic exercise training | Comparisons of Respiratory Function and Cardiorespiratory Responses Induced by the Modified Shuttle Walk Test in Children Finswimmers and Age-Matched Sedentary Non-Athletes. | Journal of clinical medicine |