University Medicine Greifswald — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications2liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
antibodies against calcitonin-gene related peptide or its receptorThis study aims to improve the pathophysiological understanding of migraine in in a longitudinal observational study investigating changes of established neurophysiological and imaging parameters in line with changes of the clinical phenotype. The study's focus is the investigation of mechanisms that are directly related to the cyclic character of migraine and its core structures. In this context, the primary endpoint is a change in the nociceptive blink reflex, an established brain stem reflex to study the trigemino-spinal system, associated with changes in migraine frequency and severity. In order to reliably detect changes in the trigeminal pain system, investigations are performed in patients before starting a prophylactic therapy and 3 months afterwards. Several secondary endpoints are used to evaluate changes of multimodal sensory and cortical information processing. Cerebral imaging will include examinations of structural and network effects of altered migraine disease activity.	Migraine	À vérifier	Traitement symptomatique	Germany	À vérifier
antibodies against calcitonin-gene related peptide or its receptorThis study aims to improve the pathophysiological understanding of migraine in in a longitudinal observational study investigating changes of established neurophysiological and imaging parameters in line with changes of the clinical phenotype. The study's focus is the investigation of mechanisms that are directly related to the cyclic character of migraine and its core structures. In this context, the primary endpoint is a change in the nociceptive blink reflex, an established brain stem reflex to study the trigemino-spinal system, associated with changes in migraine frequency and severity. In order to reliably detect changes in the trigeminal pain system, investigations are performed in patients before starting a prophylactic therapy and 3 months afterwards. Several secondary endpoints are used to evaluate changes of multimodal sensory and cortical information processing. Cerebral imaging will include examinations of structural and network effects of altered migraine disease activity.	Migraine	À vérifier	Traitement symptomatique	Germany	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
antibodies against calcitonin-gene related peptide or its receptor	Migraine	À vérifier	NCT04019496	Neurophysiology of Prophylactic Treatment in Migraine	COMPLETED

Publications

2

Molécule	Indication / population	Titre	Journal	Date
antibodies against calcitonin-gene related peptide or its receptor		Chronic xenogeneic GVHD after CAR T cell therapy limits long-term safety assessment of CAR effects using NSG mouse model.	Blood advances
antibodies against calcitonin-gene related peptide or its receptor		Comparative analyses of olfactory receptor repertoires in Schizothorax fish based on the chromosome-level genomes: Implications for regulatory roles of dietary differentiation and ploidy variation.	Comparative biochemistry and physiology. Part D, Genomics & proteomics