University Hospital Tuebingen — Biomedical Watch V2

Traitements2programmes

Essais3liés

Publications5liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Pathophysiology Based Therapy of Early Onset Epileptic EncephalopathiesGenetic epileptic encephalopathies (EEs) are a group of very rare and severe, pharmaco-resistant epilepsy forms characterized by an early onset, e.g. first years of life, and an often severe developmental delay. Genetic defects were found in different ion channels such as potassium or sodium channels explaining well the pathological neuronal hyperexcitability leading to seizures. Further mutations were also found in proteins relevant for cell structure, DNA/RNA processing or the synaptic vesicular metabolism. Specific and individualized therapies have not been established neither in the clinical routine nor in controlled studies. The goal of this monocentric non-blinded non-placebo controlled phase IIb study is the evaluation of the effectivity of anticonvulsive drugs specifically working on the ion channels defective in some subtypes of EEs in order to establish a standard and individualized therapy for these rare diseases based on the specific genetic defect.	Épilepsie	Phase 2	À vérifier	Germany	À vérifier
Pathophysiology Based Therapy of Early Onset Epileptic EncephalopathiesGenetic epileptic encephalopathies (EEs) are a group of very rare and severe, pharmaco-resistant epilepsy forms characterized by an early onset, e.g. first years of life, and an often severe developmental delay. Genetic defects were found in different ion channels such as potassium or sodium channels explaining well the pathological neuronal hyperexcitability leading to seizures. Further mutations were also found in proteins relevant for cell structure, DNA/RNA processing or the synaptic vesicular metabolism. Specific and individualized therapies have not been established neither in the clinical routine nor in controlled studies. The goal of this monocentric non-blinded non-placebo controlled phase IIb study is the evaluation of the effectivity of anticonvulsive drugs specifically working on the ion channels defective in some subtypes of EEs in order to establish a standard and individualized therapy for these rare diseases based on the specific genetic defect.	Épilepsie	Phase 2	À vérifier	Germany	À vérifier

Essais cliniques

3

Molécule	Indication / population	Phase	NCT	Titre	Statut
transcutaneous vagus nerve stimulation	SEP	Non applicable	NCT05120336	tVNS Effects on Motivation in Depression	COMPLETED
levetiracetam	Épilepsie	Phase 4	NCT00571155	Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery	COMPLETED
Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies	Épilepsie	Phase 2	NCT02968966	Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies	WITHDRAWN

Publications

5

Molécule	Indication / population	Titre	Journal	Date
Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies		SLC6A1-Related Neurodevelopmental Disorder: A Scoping Review of Clinical Features and Emerging Therapeutic Strategies.	Pediatric neurology
Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies		The clinical utility of interictal multi-channel short-duration bursts: A supplemental biomarker for epileptogenic zone localization.	Epilepsy research
Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies		SYNGAP1-related disorder: pathophysiology, epilepsy, cognitive and behavioral phenotypes, and precision therapeutic approaches.	Epilepsy & behavior : E&B
Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies		Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.	Brain and behavior
Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies		Effects of Pregestational Stress and Concomitant Administration of Dracocephalum moldavica Extract on Seizure Behaviours in Next Generation Developing Rats.	International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience