University Hospital Heidelberg — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications11liées

SourceDBlocale

Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy CardiomyopathyThe objective of this study is to evaluate acute changes of cardiac troponin (and other cardiac biomarkers) and mid-term biovariability in patients with cardiomyopathy associated with chronic skeletal muscle disease. The specific aims of the study are: Firstly, to evaluate the feasibility of the ESC 0/1 hour protocol for rule-in and rule-out of a non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Secondly, a) to determine reference change values (RCV) to characterize physiological biovariability, b) to differentiate acute from chronic high-sensitivity cardiac troponin T (hs-cTnT) elevations.	Myopathies	À vérifier	À vérifier	Germany	À vérifier
Tumor MicroenvironmentCancer immunotherapy has the great potential to achieve long-term survival in patients with a solid malignancy. However, the beneficial effect of cancer immunotherapy is seen in only a minority of patients. Mounting evidence suggests that immunosuppressive features in the tumor microenvironment prevent an effective antitumor defense. The aim of the investigators is to comprehensively analyze the cytokine profile and the tumor immune infiltrate in the tumor microenvironment and to investigate its prognostic significance in patients with radically resected lung adenocarcinoma.	Cancer	À vérifier			À vérifier
Tumor MicroenvironmentCancer immunotherapy has the great potential to achieve long-term survival in patients with a solid malignancy. However, the beneficial effect of cancer immunotherapy is seen in only a minority of patients. Mounting evidence suggests that immunosuppressive features in the tumor microenvironment prevent an effective antitumor defense. The aim of the investigators is to comprehensively analyze the cytokine profile and the tumor immune infiltrate in the tumor microenvironment and to investigate its prognostic significance in patients with radically resected lung adenocarcinoma.	Cancer	À vérifier			À vérifier
Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy CardiomyopathyThe objective of this study is to evaluate acute changes of cardiac troponin (and other cardiac biomarkers) and mid-term biovariability in patients with cardiomyopathy associated with chronic skeletal muscle disease. The specific aims of the study are: Firstly, to evaluate the feasibility of the ESC 0/1 hour protocol for rule-in and rule-out of a non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Secondly, a) to determine reference change values (RCV) to characterize physiological biovariability, b) to differentiate acute from chronic high-sensitivity cardiac troponin T (hs-cTnT) elevations.	Myopathies	À vérifier	À vérifier	Germany	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy Cardiomyopathy	Myopathies	À vérifier	NCT05779202	Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy Cardiomyopathy	COMPLETED
Tumor Microenvironment	Cancer	À vérifier	NCT05982574	Tumor Microenvironment	ACTIVE_NOT_RECRUITING

Publications

11

Molécule	Indication / population	Titre	Journal	Date
Tumor Microenvironment		CHAF1A identified as a candidate biomarker and potential therapeutic target in Burkitt lymphoma through integrated bioinformatics and histopathological analysis.	Hematology (Amsterdam, Netherlands)
Tumor Microenvironment		Apoptosis inhibitor of macrophage (AIM/CD5L) as a potential immunomodulator in feline injection-site sarcoma: a hypothesis on tumor-macrophage interactions.	The veterinary quarterly
Tumor Microenvironment		The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.	Cancer biology & therapy
Tumor Microenvironment		Immunotherapy Resistance in dMMR/MSI-H Colorectal Cancer: Unraveling Mechanisms and Exploring Overcoming Strategies.	Journal of immunology research
Tumor Microenvironment		Delivery of Mitoxantrone by Biodegradable Cobalt-Doped Hollow Prussian Blue Nanoparticles for Synergetic Photothermal Amplified Chemodynamic Therapy/Chemotherapy/Metalloimmunotherapy Against Tumor.	Small (Weinheim an der Bergstrasse, Germany)
Tumor Microenvironment		Extracellular Matrix Remodeling in Actinic Cheilitis and Lip Squamous Cell Carcinoma: A Cross-Sectional Study.	Oral diseases
Tumor Microenvironment		Revealing the Interactions of Regulatory Factors in the Immune Microenvironment of Breast Cancer Based on Two-Way Orthogonal Partial Least Square Model and Cell Communication.	Cancer medicine
Tumor Microenvironment		Discovery of Tivumecirnon (FLX475), a Potent and Selective CCR4 Antagonist That Inhibits the Migration of Immunosuppressive Regulatory T Cells into the Tumor Microenvironment to Restore Antitumor Immunity.	Journal of medicinal chemistry
Tumor Microenvironment		Revealing the Correlation Between NLRP3 Inflammasome-Related Genes and Intervertebral Disc Degeneration Based Multiomic Analysis and Experimental Validation.	Mediators of inflammation
Tumor Microenvironment		Design, Synthesis, and Biological Evaluation of Novel PAK1/HDAC10 Dual Inhibitors That Activate Antitumor Immunity for Triple-Negative Breast Cancer Treatment.	Journal of medicinal chemistry
Tumor Microenvironment		Design, Synthesis, and Evaluation of the Novel Benzimidazole Derivatives Inspired YC-1 as HIF-1α Inhibitor That Possess Anti-Colon Cancer Potential.	Drug development research