University Hospital, Tours — Biomedical Watch V2

Traitements2programmes

Essais2liés

Publications11liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Hearing aidsAlzheimer disease is a neurodegenerative disease. Recent studies suggest that subjects with hearing loss are more likely to develop Alzheimer's disease. Hearing loss can be consecutive to presbycusis and/or to central auditory dysfunction. Standard audiometric measures with pure tone and speech intelligibility allow the diagnosis of presbycusis. However, to demonstrate central auditory dysfunction, specific audiometric tests as noisy and/or dichotic tests, are needed. Actually, no consensus exists to investigate hearing loss in people with Alzheimer's disease; therefore hearing loss may be an early manifestation of Alzheimer's disease. Until now, investigations and clinical procedure related to the diagnosis of Alzheimer's disease ignored the hearing ability of the patient. However, the major part of care management and investigations implies the patient's communication ability with caregivers. Hearing loss may be one of the most unrecognized deficit in subjects with Alzheimer's disease. Auditory rehabilitation with hearing aids could benefit to the patient to decrease cognitive decline but this management must be investigate during longitudinal studies in order to demonstrate their efficiency and need to be compared with a placebo.	Alzheimer	NA	À vérifier	France	À vérifier
Hearing aidsAlzheimer disease is a neurodegenerative disease. Recent studies suggest that subjects with hearing loss are more likely to develop Alzheimer's disease. Hearing loss can be consecutive to presbycusis and/or to central auditory dysfunction. Standard audiometric measures with pure tone and speech intelligibility allow the diagnosis of presbycusis. However, to demonstrate central auditory dysfunction, specific audiometric tests as noisy and/or dichotic tests, are needed. Actually, no consensus exists to investigate hearing loss in people with Alzheimer's disease; therefore hearing loss may be an early manifestation of Alzheimer's disease. Until now, investigations and clinical procedure related to the diagnosis of Alzheimer's disease ignored the hearing ability of the patient. However, the major part of care management and investigations implies the patient's communication ability with caregivers. Hearing loss may be one of the most unrecognized deficit in subjects with Alzheimer's disease. Auditory rehabilitation with hearing aids could benefit to the patient to decrease cognitive decline but this management must be investigate during longitudinal studies in order to demonstrate their efficiency and need to be compared with a placebo.	Alzheimer	NA	À vérifier	France	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Blood sample	Lupus	À vérifier	NCT05859191	FiNKLUPUS — Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus	RECRUITING
Hearing aids	Alzheimer	NA	NCT03002142	Auditory Rehabilitation and Cognition in Alzheimer Patients	COMPLETED

Publications

11

Molécule	Indication / population	Titre	Journal	Date
Hearing aids		Evaluating the efficacy of artificial intelligence in audiology: a head-to-head comparison of ChatGPT and Gemini on hearing aid management.	International journal of medical informatics
Hearing aids		Hydrogen: a novel strategy for preventing and treating hearing loss.	Medical gas research
Hearing aids		Living with age-related hearing loss and insights for hearing care: a qualitative descriptive study.	International journal of qualitative studies on health and well-being
Hearing aids		[Effects of bone conduction device on speech recognition in noise and listening effort in patients with single-sided deafness].	Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery
Hearing aids		Intelligibility of Emotional Speech in Chinese Older Adults: Effects of Age-Related Hearing Loss.	Journal of speech, language, and hearing research : JSLHR
Hearing aids		Health and disability assessment in individuals with hearing loss: a longitudinal study using WHODAS 2.0.	CoDAS
Hearing aids		Precision correction of the GJB2 c.235delC mutation by prime editing in vitro.	Gene therapy
Hearing aids		Evaluating Telugu Speech Perception Measures for Hearing-Aid Benefit: Rationale for Developing Telugu Speech-in-Noise Tests.	Noise & health
Hearing aids		Effects of Hearing Aids in a Simulated Open-Plan Office: A Laboratory Study Involving Normal-Hearing Participants and Simulated Hearing Loss.	Noise & health
Hearing aids		Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.	Cellular and molecular life sciences : CMLS
Hearing aids		Hearing Rehabilitation in Veterans With Severe Hearing Loss: Challenges and Opportunities.	Ear and hearing