Université Catholique de Louvain — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications0liées

SourceDBlocale

Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
EXIMIOUS — Occupational and Environmental Causes of Autoimmune DiseasesThe investigators hypothesize that part of the systemic autoimmune diseases (AID) patients might prove to have an occupational or environmental disease which is potentially preventable. The recognition of the occupational or environmental etiology of autoimmune disorders has major implications for patients and society and will generate opportunity for prevention and meaningful clinical intervention. The investigators intend to use the urine/blood exposure measurements to demonstrate the etiological role of environment in patients developing AID patients. The investigators are mounting an epidemiological study to elucidate the environmental etiology of AID and their effects on the immune profile and disease course. A population-based case-control study will be done with adult patients with newly diagnosed systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis (n=100 per disease).	Lupus	NA		Belgium	À vérifier
The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to TreatmentMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) and the leading non-traumatic cause of neurological disability in young adults. Historically considered a T-cell-mediated disease, the paradigm for MS has shifted thanks to the efficacy of therapies targeting B cells. The investigators recently identified FCRL5 as a B-cell-specific biomarker that is significantly elevated in the cerebrospinal fluid (CSF) of patients with relapsing-remitting MS and is independently associated with an increased risk of developing new MRI lesions within two years of diagnosis (ref. Deltombe et al., PMID: 41004694). This project aims to further explore FCRL5 as a prognostic biomarker, study the role of FCRL5-expressing B cells in MS pathogenesis and the effects of disease-modifying therapies on these subsets.	SEP	À vérifier	Immunomodulation	Belgium	À vérifier
EXIMIOUS — Occupational and Environmental Causes of Autoimmune DiseasesThe investigators hypothesize that part of the systemic autoimmune diseases (AID) patients might prove to have an occupational or environmental disease which is potentially preventable. The recognition of the occupational or environmental etiology of autoimmune disorders has major implications for patients and society and will generate opportunity for prevention and meaningful clinical intervention. The investigators intend to use the urine/blood exposure measurements to demonstrate the etiological role of environment in patients developing AID patients. The investigators are mounting an epidemiological study to elucidate the environmental etiology of AID and their effects on the immune profile and disease course. A population-based case-control study will be done with adult patients with newly diagnosed systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis (n=100 per disease).	Lupus	NA		Belgium	À vérifier
The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to TreatmentMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) and the leading non-traumatic cause of neurological disability in young adults. Historically considered a T-cell-mediated disease, the paradigm for MS has shifted thanks to the efficacy of therapies targeting B cells. The investigators recently identified FCRL5 as a B-cell-specific biomarker that is significantly elevated in the cerebrospinal fluid (CSF) of patients with relapsing-remitting MS and is independently associated with an increased risk of developing new MRI lesions within two years of diagnosis (ref. Deltombe et al., PMID: 41004694). This project aims to further explore FCRL5 as a prognostic biomarker, study the role of FCRL5-expressing B cells in MS pathogenesis and the effects of disease-modifying therapies on these subsets.	SEP	À vérifier	Immunomodulation	Belgium	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to Treatment	SEP	À vérifier	NCT07788573	The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to Treatment	NOT_YET_RECRUITING
EXIMIOUS — Occupational and Environmental Causes of Autoimmune Diseases	Lupus	NA	NCT07000903	EXIMIOUS — Occupational and Environmental Causes of Autoimmune Diseases	COMPLETED

Publications

0

Molécule	Indication / population	Titre	Journal	Date
Aucune publication.