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Sunnybrook Health Sciences Centre
Traitements, essais et publications liés.
Traitements12programmes
Essais7liés
Publications18liées
SourceDBlocale
Traitements
12| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Definity® Vial for (Perflutren Lipid Microsphere) Injectable SuspensionDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | Phase 1 | À vérifier | Canada | À vérifier |
| Floxuridine (FUDR)The goal of this clinical trial is to assess how many patients with initially inoperable colorectal liver metastasis are able to have a liver surgery after treatment with hepatic artery infusion chemotherapy and standard of care systemic chemotherapy. | Cancer | Phase 2 | À vérifier | Canada | À vérifier |
| Intravenous immunoglobulin (IVIG), 10% solution for infusionDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | Phase 1 | À vérifier | Canada | À vérifier |
| Monoplace Hyperbaric Chamber (Class III medical device).Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of the disease. This condition is known as post COVID-19 condition, which can have serious health consequences. A common symptom among these individuals is chronic fatigue, characterized by persistent tiredness or lack of energy. This study aims to explore a novel treatment for symptoms of post COVID-19 condition, known as hyperbaric oxygen therapy. This approach has shown promise in helping people with post COVID-19 conditions and treating some other causes of fatigue. Hyperbaric oxygen therapy involves placing patients in a small chamber where they receive high oxygen gas levels. However, this treatment is expensive and time-consuming, and it is unclear if this treatment can be effectively assessed in a large-scale research study. This small study will help us decide if conducting a large research study is feasible. The investigators aim to assess if hyperbaric oxygen therapy can improve symptoms of post COVID-19 condition, such as fatigue. | Myopathies | Non applicable | Traitement symptomatique | Canada | À vérifier |
| Next Generation Dome Helmet Focused UltrasoundDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | Phase 1 | À vérifier | Canada | À vérifier |
| PerindoprilTo conduct a proof of concept study in patients with mild to moderate Alzheimer's Disease in order to determine if there is less global brain atrophy over one year, as measured by ventricular enlargement as a primary outcome measure, when patients are randomized to treatment with an angiotensin receptor blocker (ARB) compared to an angiotensin converting enzyme inhibitor (ACEI). | Alzheimer | Phase 2 | À vérifier | Canada | À vérifier |
| TelmisartanTo conduct a proof of concept study in patients with mild to moderate Alzheimer's Disease in order to determine if there is less global brain atrophy over one year, as measured by ventricular enlargement as a primary outcome measure, when patients are randomized to treatment with an angiotensin receptor blocker (ARB) compared to an angiotensin converting enzyme inhibitor (ACEI). | Alzheimer, Hypertension | Phase 2 | À vérifier | Canada | À vérifier |
| PerindoprilTo conduct a proof of concept study in patients with mild to moderate Alzheimer's Disease in order to determine if there is less global brain atrophy over one year, as measured by ventricular enlargement as a primary outcome measure, when patients are randomized to treatment with an angiotensin receptor blocker (ARB) compared to an angiotensin converting enzyme inhibitor (ACEI). | Alzheimer | Phase 2 | À vérifier | Canada | À vérifier |
| TelmisartanTo conduct a proof of concept study in patients with mild to moderate Alzheimer's Disease in order to determine if there is less global brain atrophy over one year, as measured by ventricular enlargement as a primary outcome measure, when patients are randomized to treatment with an angiotensin receptor blocker (ARB) compared to an angiotensin converting enzyme inhibitor (ACEI). | Hypertension | Phase 3 | À vérifier | Denmark, Finland, Netherlands, Norway, Sweden, United Kingdom | À vérifier |
| Next Generation Dome Helmet Focused UltrasoundDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | Phase 1 | À vérifier | Canada | À vérifier |
| Floxuridine (FUDR)The goal of this clinical trial is to assess how many patients with initially inoperable colorectal liver metastasis are able to have a liver surgery after treatment with hepatic artery infusion chemotherapy and standard of care systemic chemotherapy. | Cancer | Phase 2 | À vérifier | Canada | À vérifier |
| Monoplace Hyperbaric Chamber (Class III medical device).Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of the disease. This condition is known as post COVID-19 condition, which can have serious health consequences. A common symptom among these individuals is chronic fatigue, characterized by persistent tiredness or lack of energy. This study aims to explore a novel treatment for symptoms of post COVID-19 condition, known as hyperbaric oxygen therapy. This approach has shown promise in helping people with post COVID-19 conditions and treating some other causes of fatigue. Hyperbaric oxygen therapy involves placing patients in a small chamber where they receive high oxygen gas levels. However, this treatment is expensive and time-consuming, and it is unclear if this treatment can be effectively assessed in a large-scale research study. This small study will help us decide if conducting a large research study is feasible. The investigators aim to assess if hyperbaric oxygen therapy can improve symptoms of post COVID-19 condition, such as fatigue. | Myopathies | Non applicable | Traitement symptomatique | Canada | À vérifier |
Essais cliniques
7| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Monoplace Hyperbaric Chamber (Class III medical device). | Myopathies | Non applicable | NCT06082518 | PCS-HBOT — Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments | ACTIVE_NOT_RECRUITING |
| CBD | Alzheimer | Phase 2 | NCT06014424 | CALM-IT — Cannabidiol Medication Intervention Trial | RECRUITING |
| Floxuridine (FUDR) | Cancer | Phase 2 | NCT07764497 | HAIP-6192 — Hepatic Arterial Infusion Chemotherapy in Patients With Inoperable Colorectal Cancer Liver Metastasis | RECRUITING |
| Next Generation Dome Helmet Focused Ultrasound | Sclérose latérale amyotrophique | Phase 1 | NCT07193953 | ALSFUS003 — Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS) | ACTIVE_NOT_RECRUITING |
| Eptinezumab | Migraine | Phase 3 | NCT07191145 | Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT) | NOT_YET_RECRUITING |
| Telmisartan | Hypertension | Phase 3 | NCT00274118 | DETAIL Study: Diabetes Exposed to Telmisartan and Enalapril | COMPLETED |
| Perindopril | Alzheimer | Phase 2 | NCT02085265 | Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients | TERMINATED |
Publications
18| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Perindopril | Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial. | American journal of hypertension | ||
| Perindopril | Yiqi Huoxue formula promotes post-myocardial infarction angiogenesis by modulating mitochondria-associated membranes (MAMs) and calcium homeostasis via the cGMP/PKG signaling pathway. | Journal of ethnopharmacology | ||
| Intravenous immunoglobulin (IVIG), 10% solution for infusion | Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial. | The Lancet. Respiratory medicine | ||
| Intravenous immunoglobulin (IVIG), 10% solution for infusion | A Comparative Real-World Study Evaluating the Safety of Immune Globulin Infusion (Human) 10% Solution and Other Intravenous Immunoglobulin Therapies for the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy. | Pharmacoepidemiology and drug safety | ||
| Intravenous immunoglobulin (IVIG), 10% solution for infusion | The Results of ADVANCE-CIDP IVIG Trial: Intravenous Immunoglobulin 10% Therapy With GAMMAGARD LIQUID/Kiovig for Treatment of Relapse in Chronic Inflammatory Demyelinating Polyradiculoneuropathy. | European journal of neurology | ||
| Telmisartan | Preclinical Pharmacokinetics of Erdafitinib, an FGFR Tyrosine Kinase Inhibitor, via LC-MS/MS in Sprague Dawley Rats. | Rapid communications in mass spectrometry : RCM | ||
| Telmisartan | Identification of hypertension-associated bacterial key genes as potential targets and therapeutic agents through integrated bioinformatics approach. | International microbiology : the official journal of the Spanish Society for Microbiology | ||
| Telmisartan | Dual-cargo polymeric micelles with tumor-cell/stroma dual-targeting for synergistic eradication of drug-resistant breast cancer. | Biomaterials science | ||
| Perindopril | Liver sinusoidal endothelial cell (LSEC) defenestration in chronic heart failure is primarily dependent on cardiac diastolic dysfunction and is reversed by sodium-glucose cotransporter 2 inhibitor but not by angiotensin-converting enzyme inhibitor. | Cardiovascular research | ||
| Telmisartan | Telmisartan, P-glycoprotein inhibition, and bleeding risk in DOAC-treated patients with atrial fibrillation. | Hypertension research : official journal of the Japanese Society of Hypertension | ||
| Telmisartan | Drug-associated psoriasis: a pharmacovigilance study based on the FAERS database. | Frontiers in pharmacology | ||
| Perindopril | Digital pharmacoepidemiology of angiotensin-converting enzyme inhibitors in Russia. | Frontiers in pharmacology | ||
| Perindopril | Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence. | American journal of cardiovascular drugs : drugs, devices, and other interventions | ||
| Perindopril | Nebivolol treatment improves hypertension-induced endothelial cell dysfunction by reducing TGF-β1-dependent senescence and normalizing mitochondrial indices. | Journal of hypertension | ||
| Telmisartan | Optimizing a carbon source based on water temperature to reduce abundance and promote beneficial bacteria in a shrimp biofloc system in China: a preliminary study. | Frontiers in systems biology | ||
| Telmisartan | Evaluating ATR expression and the effects of renin-angiotensin system inhibition in a mouse model of cerebral amyloid angiopathy. | Brain research | ||
| Perindopril | Facilitatory effects of LY404187, a positive allosteric modulator of AMPA receptors, on swallowing initiation in anesthetized male rats. | Archives of oral biology | ||
| Perindopril | Behavioral Effects of Renin-Angiotensin System Modulators in a Rotenone-Induced Model of Parkinson's Disease in Wistar Albino Rats. | Cureus |