Stanford University — Biomedical Watch V2

Traitements12programmes

Essais8liés

Publications4liées

SourceDBlocale

Traitements

12

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
BumetanideThis study aims to investigate bumetanide in patients with biologically confirmed Alzheimer's disease (AD). Bumetanide is a potent diuretic administered orally and is FDA approved for the treatment of edema and hypertension. Repurposing bumetanide as a medication for AD has been proposed based on data that demonstrated its ability to "flip" the APOE genotype-dependent transcriptomic signatures in AD mouse and cell culture models. Critically, this discovery was subsequently explored in Electronic Health Record cohorts, which revealed that among individuals over the age of 65, bumetanide exposure was significantly associated with a lower prevalence of AD in three independent datasets. Primary Objective: To evaluate the safety and tolerability of bumetanide when administered to participants with biomarker-confirmed Alzheimer's disease. Secondary Objective: To evaluate the clinical and biomarker effects of bumetanide in participants with mild cognitive impairment or mild dementia due to Alzheimer's disease.	Alzheimer	Phase 2	À vérifier	United States	À vérifier
Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure MonitorThe goal of this clinical trial is to learn whether providing teaching with a low-cost device can help to improve blood pressure, health outcomes, patient self-efficacy without exacerbating inequity between advantaged and disadvantaged patients. The main question\[s\] it aims to answer are: 1. Does providing a free home blood pressure cuff improve control of hypertension? 2. Does providing a free home blood pressure cuff have a greater impact on control of hypertension in disadvantaged populations? 3. Does improved control of home blood pressure decrease adverse patient outcomes? Participants will be asked to * Take their blood pressure at home and records the results * Participate in follow-up phone calls from investigators at at 3 and 6 months Researchers will compare patients provided with home blood pressure monitors to those who are provided with routine education	Hypertension	NA	À vérifier	United States	À vérifier
PAANS — Pharmacology of Aminophylline for Acute Kidney Injury in NeonatesAcute kidney injury (AKI) in critically ill neonates is common and associated with significant morbidity and mortality. No targeted therapeutic treatment strategies have been established for AKI in neonates. Within a clinical pharmacokinetic and pharmacodynamic conceptual framework, this project will examine the medication aminophylline as a potential treatment approach for AKI.	SEP	À vérifier	À vérifier	United States	À vérifier
Vagus nerve stimulationVagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients. We aimed in the current study, to evaluate the effect of the cervical transcutaneous vagus nerve stimulation in comparison to conventional medical treatment in Egyptian fibromyalgia patients.	Myopathies, SEP	Non applicable	À vérifier	China	À vérifier
Vibrotactile StimulationThe purpose of this study is to perform a first in man study with VCR stimulation of the belly and back for patients with chronic pain conditions including pelvic pain, functional abdominal pain, or low back pain. This study will also examine VCR stimulation of the temporal region for patients with migraine with or without aura. Additional goals of the study will be to determine the safety, tolerability, and acceptability of VCR stimulation for the treatment of these pain conditions.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
BumetanideThis study aims to investigate bumetanide in patients with biologically confirmed Alzheimer's disease (AD). Bumetanide is a potent diuretic administered orally and is FDA approved for the treatment of edema and hypertension. Repurposing bumetanide as a medication for AD has been proposed based on data that demonstrated its ability to "flip" the APOE genotype-dependent transcriptomic signatures in AD mouse and cell culture models. Critically, this discovery was subsequently explored in Electronic Health Record cohorts, which revealed that among individuals over the age of 65, bumetanide exposure was significantly associated with a lower prevalence of AD in three independent datasets. Primary Objective: To evaluate the safety and tolerability of bumetanide when administered to participants with biomarker-confirmed Alzheimer's disease. Secondary Objective: To evaluate the clinical and biomarker effects of bumetanide in participants with mild cognitive impairment or mild dementia due to Alzheimer's disease.	Alzheimer	Phase 2	À vérifier	United States	À vérifier
Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure MonitorThe goal of this clinical trial is to learn whether providing teaching with a low-cost device can help to improve blood pressure, health outcomes, patient self-efficacy without exacerbating inequity between advantaged and disadvantaged patients. The main question\[s\] it aims to answer are: 1. Does providing a free home blood pressure cuff improve control of hypertension? 2. Does providing a free home blood pressure cuff have a greater impact on control of hypertension in disadvantaged populations? 3. Does improved control of home blood pressure decrease adverse patient outcomes? Participants will be asked to * Take their blood pressure at home and records the results * Participate in follow-up phone calls from investigators at at 3 and 6 months Researchers will compare patients provided with home blood pressure monitors to those who are provided with routine education	Hypertension	NA	À vérifier	United States	À vérifier
Vibrotactile StimulationThe purpose of this study is to perform a first in man study with VCR stimulation of the belly and back for patients with chronic pain conditions including pelvic pain, functional abdominal pain, or low back pain. This study will also examine VCR stimulation of the temporal region for patients with migraine with or without aura. Additional goals of the study will be to determine the safety, tolerability, and acceptability of VCR stimulation for the treatment of these pain conditions.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Vagus nerve stimulationVagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients. We aimed in the current study, to evaluate the effect of the cervical transcutaneous vagus nerve stimulation in comparison to conventional medical treatment in Egyptian fibromyalgia patients.	Myopathies	Non applicable	À vérifier	Egypt	À vérifier
Vagus nerve stimulationVagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients. We aimed in the current study, to evaluate the effect of the cervical transcutaneous vagus nerve stimulation in comparison to conventional medical treatment in Egyptian fibromyalgia patients.	SEP	Non applicable	À vérifier	China	À vérifier
PAANS — Pharmacology of Aminophylline for Acute Kidney Injury in NeonatesAcute kidney injury (AKI) in critically ill neonates is common and associated with significant morbidity and mortality. No targeted therapeutic treatment strategies have been established for AKI in neonates. Within a clinical pharmacokinetic and pharmacodynamic conceptual framework, this project will examine the medication aminophylline as a potential treatment approach for AKI.	SEP	À vérifier	À vérifier	United States	À vérifier
Vagus nerve stimulationVagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients. We aimed in the current study, to evaluate the effect of the cervical transcutaneous vagus nerve stimulation in comparison to conventional medical treatment in Egyptian fibromyalgia patients.	SEP	Non applicable	À vérifier		À vérifier

Essais cliniques

8

Molécule	Indication / population	Phase	NCT	Titre	Statut
Vagus nerve stimulation	SEP	Non applicable	NCT07310381	Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement	NOT_YET_RECRUITING
PAANS — Pharmacology of Aminophylline for Acute Kidney Injury in Neonates	SEP	À vérifier	NCT02276170	PAANS — Pharmacology of Aminophylline for Acute Kidney Injury in Neonates	TERMINATED
Aminophylline	SEP	Non applicable	NCT01245595	KIDPROAM — Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery	COMPLETED
Vagus nerve stimulation	SEP	Non applicable	NCT06923007	Advant — Alzheimer's Disease Treated With Vagus Nerve Stimulation	RECRUITING
Vagus nerve stimulation	Myopathies	Non applicable	NCT06237595	Vagus Nerve Stimulation in Fibromyalgia	COMPLETED
Vibrotactile Stimulation	Migraine	Non applicable	NCT04069572	Vibratory Stimulation for the Treatment of Chronic Pain	SUSPENDED
Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure Monitor	Hypertension	NA	NCT05730465	Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure Monitor	UNKNOWN
Bumetanide	Alzheimer	Phase 2	NCT06052163	BumxAD — Bumetanide in Patients With Alzheimer's Disease	RECRUITING

Publications

4

Molécule	Indication / population	Titre	Journal	Date
Vagus nerve stimulation		Vagus nerve stimulation as an add-on therapy in patients with epilepsy: a prospective, multicenter, real-world study in China.	Acta epileptologica
Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure Monitor		A village health worker intervention to reduce cardiovascular disease risk in remote areas of armed conflict in Myanmar-results from a feasibility study in three villages.	Conflict and health
Bumetanide		The NKCC1 Antagonist Bumetanide, Administered After Prenatal Alcohol Exposure, Mitigates Ethanol-Induced Aberrance in Tangential Migration of GABAergic Interneurons in Mouse Medial Prefrontal Cortex.	Alcohol, clinical & experimental research
Bumetanide		Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors.	Frontiers in chemistry