St. Olavs Hospital — Biomedical Watch V2

Traitements6programmes

Essais4liés

Publications6liées

SourceDBlocale

Traitements

6

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Atorvastatin 20mgThe main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be confirmed in a larger, multicenter, randomized controlled parallel group study. In addition it will be investigated whether 1) there is an effect of a daily dose of 20mg Atorvastatin, 2) whether the favorable side effect profile, seen in previous studies, can be confirmed, and whether it is even better with the smaller dose, and 3) estimating the cost of Atorvastatin treatment, considering cost of medicine, cost of acute attack medicine, and cost of lost worktime.	Migraine	Phase 2	À vérifier	Norway	À vérifier
Atorvastatin 40mgThe main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be confirmed in a larger, multicenter, randomized controlled parallel group study. In addition it will be investigated whether 1) the favorable side effect profile, seen in previous studies, can be confirmed, and whether it is even better with the smaller dose, and 2) estimating the cost of Atorvastatin treatment, considering cost of medicine, cost of acute attack medicine, and cost of lost worktime.	Migraine	Phase 2	À vérifier	Norway	À vérifier
CryoneurolysisThe trial is a research study that tests a freezing technique called cryoneurolysis to see if it helps relieve pain in adults with chronic migraine. Chronic migraine is a condition that causes moderate to severe headache. In this study, the investigators want to evaluate the freezing technique in chronic migraine. The main goal is to see how much headache relief is experienced after receiving the treatment. The investigators will also record other important information about the participants. The study is looking to recruit 12 adults with chronic migraine to take part in the study. Participants will register their headache burden in a headache diary for at least 4 weeks before receiving treatment with the freezing technique. They will continue to register headache in the headache diary during the follow-up. After this initial treatment, participants with recurring headache can receive treatment as needed for up to two years. The results of this study will help us decide if the freezing technique may be viable treatment option for chronic migraine and enable us plan for further studies on this treatment.	Migraine	Non applicable	Traitement symptomatique	Norway	À vérifier
Atorvastatin 40mgThe main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be confirmed in a larger, multicenter, randomized controlled parallel group study. In addition it will be investigated whether 1) the favorable side effect profile, seen in previous studies, can be confirmed, and whether it is even better with the smaller dose, and 2) estimating the cost of Atorvastatin treatment, considering cost of medicine, cost of acute attack medicine, and cost of lost worktime.	Migraine	Phase 2	À vérifier	Norway	À vérifier
Atorvastatin 40mgThe main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be confirmed in a larger, multicenter, randomized controlled parallel group study. In addition it will be investigated whether 1) the favorable side effect profile, seen in previous studies, can be confirmed, and whether it is even better with the smaller dose, and 2) estimating the cost of Atorvastatin treatment, considering cost of medicine, cost of acute attack medicine, and cost of lost worktime.	Migraine	Phase 2	À vérifier	Norway	À vérifier
CryoneurolysisThe trial is a research study that tests a freezing technique called cryoneurolysis to see if it helps relieve pain in adults with chronic migraine. Chronic migraine is a condition that causes moderate to severe headache. In this study, the investigators want to evaluate the freezing technique in chronic migraine. The main goal is to see how much headache relief is experienced after receiving the treatment. The investigators will also record other important information about the participants. The study is looking to recruit 12 adults with chronic migraine to take part in the study. Participants will register their headache burden in a headache diary for at least 4 weeks before receiving treatment with the freezing technique. They will continue to register headache in the headache diary during the follow-up. After this initial treatment, participants with recurring headache can receive treatment as needed for up to two years. The results of this study will help us decide if the freezing technique may be viable treatment option for chronic migraine and enable us plan for further studies on this treatment.	Migraine	Non applicable	Traitement symptomatique	Norway	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
Cryoneurolysis	Migraine	Non applicable	NCT06554886	A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic Migraine	ACTIVE_NOT_RECRUITING
Atorvastatin 40mg	Migraine	Phase 2	NCT06248671	EStatinMig — Prophylactic Treatment With Atorvastatin for Episodic Migraine.	RECRUITING
Atorvastatin 40mg	Migraine	Phase 2	NCT06485336	Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)	RECRUITING
Botulinum toxin type A	Migraine	Phase 3	NCT04069897	MiBlock — Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine	COMPLETED

Publications

6

Molécule	Indication / population	Titre	Journal	Date
Atorvastatin 20mg		E-selectin and TFPI are associated with carotid intima-media thickness in stable IHD patients: the baseline findings of the MIAMI study.	Nutrition, metabolism, and cardiovascular diseases : NMCD
Atorvastatin 20mg		Expert consensus on drug treatment of chronic subdural hematoma.	Chinese neurosurgical journal
Atorvastatin 20mg		Evaluation of Flavonoid-rich Fraction of Aerial Part Extract in Atherogenic Diet-induced Atherosclerosis.	Combinatorial chemistry & high throughput screening
Atorvastatin 40mg		"Two for One", Novel Dual Left Anterior Descending Artery (LAD) Variant: Type XIII.	Cureus
Atorvastatin 40mg		Use of Statin and Target Low-density lipoprotein cholesterol attainment among post-ST elevation myocardial infarction patients in Shahid Gangalal National Heart Centre, Kathmandu, Nepal.	Journal of Nepal Health Research Council
Atorvastatin 40mg		Effectiveness of Lower Range of High-intensity Statin Therapy in Lowering LDL-C among STEMI Patients.	Journal of Nepal Health Research Council