Seattle Children's Hospital — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications4liées

SourceDBlocale

Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled TrialInsomnia is a common comorbidity among adolescents with migraine. This randomized controlled clinical trial aims to determine efficacy of cognitive-behavioral therapy (CBT) for insomnia, as well as the combined effect of CBT insomnia and pain interventions, on reducing insomnia symptoms and headache-related disability in adolescents with migraine. The long-term goal is to offer effective, tailored self-management interventions that can address migraine and co-morbid sleep problems in adolescence and disrupt a cycle of persistent, disabling migraine from continuing into adulthood.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Radiofrequency ablation (RFA)This is a single-center, Phase II study including only patients on whom a decision to conduct radiofrequency ablation (RFA) has already been made. The primary objective of this study assess if quality of life was improved by RFA as assessed at baseline, 3 and potentially 6 and 12 months following RFA for the benign lesions. RFA is an imaging guided percutaneous or intra-operative procedure that uses a probe on the end of a sharp needle that is inserted directly into the tumor. The tumor is ablated by heating the probe (using an electrical current alternating at radio frequency) which raises the temperature of the tumor potentially causing irreversible cell death. RF ablation is an alternative for local tumor control when other treatments (surgery, radiotherapy or chemotherapy) are not feasible (less effective or at higher risk). Thermal ablation at times is the only remaining alternative for patient cure, prolonged survival or palliation. Cryotherapy, and microwave, laser and focused ultrasound are alternative thermal ablation techniques used in adults but there has been no experience in children with these alternative methods. To be eligible for this study, patients must have acquired lesions at \< 21 years of age (central nervous system lesions are excluded from this study). Study participants will have the RFA procedure performed at Seattle Children's and will have follow-up evaluations at various time points post-RFA.	Cancer	Phase 2	À vérifier	United States	À vérifier
I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled TrialInsomnia is a common comorbidity among adolescents with migraine. This randomized controlled clinical trial aims to determine efficacy of cognitive-behavioral therapy (CBT) for insomnia, as well as the combined effect of CBT insomnia and pain interventions, on reducing insomnia symptoms and headache-related disability in adolescents with migraine. The long-term goal is to offer effective, tailored self-management interventions that can address migraine and co-morbid sleep problems in adolescence and disrupt a cycle of persistent, disabling migraine from continuing into adulthood.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Radiofrequency ablation (RFA)This is a single-center, Phase II study including only patients on whom a decision to conduct radiofrequency ablation (RFA) has already been made. The primary objective of this study assess if quality of life was improved by RFA as assessed at baseline, 3 and potentially 6 and 12 months following RFA for the benign lesions. RFA is an imaging guided percutaneous or intra-operative procedure that uses a probe on the end of a sharp needle that is inserted directly into the tumor. The tumor is ablated by heating the probe (using an electrical current alternating at radio frequency) which raises the temperature of the tumor potentially causing irreversible cell death. RF ablation is an alternative for local tumor control when other treatments (surgery, radiotherapy or chemotherapy) are not feasible (less effective or at higher risk). Thermal ablation at times is the only remaining alternative for patient cure, prolonged survival or palliation. Cryotherapy, and microwave, laser and focused ultrasound are alternative thermal ablation techniques used in adults but there has been no experience in children with these alternative methods. To be eligible for this study, patients must have acquired lesions at \< 21 years of age (central nervous system lesions are excluded from this study). Study participants will have the RFA procedure performed at Seattle Children's and will have follow-up evaluations at various time points post-RFA.	Cancer	Phase 2	À vérifier	United States	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Radiofrequency ablation (RFA)	Cancer	Phase 2	NCT00868647	Radiofrequency Ablation (RFA) Of Tumors Acquired In Childhood	SUSPENDED
I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial	Migraine	Non applicable	NCT04936321	I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial	COMPLETED

Publications

4

Molécule	Indication / population	Titre	Journal	Date
I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial		Efficacy and safety of transcutaneous electrical nerve stimulation in the treatment of moderate-to-severe itch after burns on limbs (TE-ITCH): protocol for a multicentre, randomised, placebo-controlled clinical trial.	BMJ open
I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial		Effect of Extracorporeal Shock Wave Therapy Combined With Kinesio Taping on Shoulder Function in Patients With Long-Head Biceps Tendinopathy: A Randomized Controlled Trial.	Archives of physical medicine and rehabilitation
I-SPY-RCT — Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial		Preoperative photobiomodulation reduces pain in molar surgery: A, double-blind clinical trial.	Journal of dentistry
Radiofrequency ablation (RFA)		Analysis of Lesion Shrinkage and Factors Influencing Shrinkage Following Radiofrequency Ablation of Breast Nodules: An Observational Study.	Journal of investigative surgery : the official journal of the Academy of Surgical Research