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Ruijin Hospital
Traitements, essais et publications liés.
Traitements10programmes
Essais5liés
Publications16liées
SourceDBlocale
Traitements
10| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| 3D-printed coplanar templateThis study evaluates the application of 3D-printed template for iodine-125 seed implantation therapy in patients with locally advanced pancreatic cancer. Half of participants will receive 3D-printed coplanar template, while the other half will receive 3D-printed non-coplanar template. | Cancer | NA | À vérifier | China | À vérifier |
| 3D-printed non-coplanar templateThis study evaluates the application of 3D-printed template for iodine-125 seed implantation therapy in patients with locally advanced pancreatic cancer. Half of participants will receive 3D-printed coplanar template, while the other half will receive 3D-printed non-coplanar template. | Cancer | NA | À vérifier | China | À vérifier |
| Intermittent theta burst stimulationAlzheimer's disease (AD) is a progressive neurodegenerative condition affecting 6.2 million individuals in the United States, resulting in an annual cost of care of $305 billion. AD is functionally characterized by progressive degeneration of large-scale brain networks (LSBNs), including the default mode network (DMN) presumably from the deposition of amyloid plaques and neurofibrillary tangles. Available FDA-approved medications for AD such as donepezil and memantine offer limited benefit and modest impact on quality of life. In combination with resting state functional MRI (rs-fMRI), transcranial magnetic stimulation (TMS) with intermittent theta burst stimulation (iTBS) offers a non-invasive alternative to pharmacotherapy in persons with AD. We propose a pilot trial using rs-fMRI to target dysfunctional LSBNs in early stage AD. | Alzheimer, Myopathies, Parkinson | Non applicable | À vérifier | China | À vérifier |
| NervioX-2400The goal of this clinical trial is to evaluate the immediate effects of individualized 130 Hz STN-tTIS(Subthalamic Nucleus - transcranial Temporal Interference Stimulation)on motor symptoms in early-to-mid-stage PD patients during both medication "on" and "off" states. The main questions it aims to answer are: 1. Does the therapeutic effect of STN - tTIS relate to medication? 2. The degree of improvement in motor symptoms of Parkinson's disease patients after STN - tTIS therapy under different medication conditions. Researchers compared the MDS - UPDRS - III improvement scores of tTIS therapy in the "on" and "off" medication phases to see if tTIS could work of independently medication. 1. Visit the clinic once every 1 weeks for therapy and test. 2. Record their symptoms and scores. | Parkinson | Non applicable | Traitement symptomatique | China | À vérifier |
| sham iTBSIntermittent theta burst stimulation (iTBS) is an emerging non-invasive neuron regulation technique, which is widely used in neuropsychiatry for a variety of diseases and is widely accepted by patients due to its non-invasive, operable and relatively precise localization. Combining the results of previous studies and our group's previous research, sixty qualified PD patients would be enrolled to conduct a prospective single-center randomized double-blind sham controlled clinical trial to verify the long-term curative effects of iTBS treatment protocol and explore the neuron-protection of iTBS on neuronal loss of PD patients. | Parkinson | Non applicable | À vérifier | China | À vérifier |
| Intermittent theta burst stimulationAlzheimer's disease (AD) is a progressive neurodegenerative condition affecting 6.2 million individuals in the United States, resulting in an annual cost of care of $305 billion. AD is functionally characterized by progressive degeneration of large-scale brain networks (LSBNs), including the default mode network (DMN) presumably from the deposition of amyloid plaques and neurofibrillary tangles. Available FDA-approved medications for AD such as donepezil and memantine offer limited benefit and modest impact on quality of life. In combination with resting state functional MRI (rs-fMRI), transcranial magnetic stimulation (TMS) with intermittent theta burst stimulation (iTBS) offers a non-invasive alternative to pharmacotherapy in persons with AD. We propose a pilot trial using rs-fMRI to target dysfunctional LSBNs in early stage AD. | Alzheimer | NA | À vérifier | United States | À vérifier |
| 3D-printed non-coplanar templateThis study evaluates the application of 3D-printed template for iodine-125 seed implantation therapy in patients with locally advanced pancreatic cancer. Half of participants will receive 3D-printed coplanar template, while the other half will receive 3D-printed non-coplanar template. | Cancer | NA | À vérifier | China | À vérifier |
| Intermittent theta burst stimulationAlzheimer's disease (AD) is a progressive neurodegenerative condition affecting 6.2 million individuals in the United States, resulting in an annual cost of care of $305 billion. AD is functionally characterized by progressive degeneration of large-scale brain networks (LSBNs), including the default mode network (DMN) presumably from the deposition of amyloid plaques and neurofibrillary tangles. Available FDA-approved medications for AD such as donepezil and memantine offer limited benefit and modest impact on quality of life. In combination with resting state functional MRI (rs-fMRI), transcranial magnetic stimulation (TMS) with intermittent theta burst stimulation (iTBS) offers a non-invasive alternative to pharmacotherapy in persons with AD. We propose a pilot trial using rs-fMRI to target dysfunctional LSBNs in early stage AD. | Parkinson | Non applicable | Neuroprotection | China | À vérifier |
| NervioX-2400The goal of this clinical trial is to evaluate the immediate effects of individualized 130 Hz STN-tTIS(Subthalamic Nucleus - transcranial Temporal Interference Stimulation)on motor symptoms in early-to-mid-stage PD patients during both medication "on" and "off" states. The main questions it aims to answer are: 1. Does the therapeutic effect of STN - tTIS relate to medication? 2. The degree of improvement in motor symptoms of Parkinson's disease patients after STN - tTIS therapy under different medication conditions. Researchers compared the MDS - UPDRS - III improvement scores of tTIS therapy in the "on" and "off" medication phases to see if tTIS could work of independently medication. 1. Visit the clinic once every 1 weeks for therapy and test. 2. Record their symptoms and scores. | Parkinson | Non applicable | Traitement symptomatique | China | À vérifier |
| Intermittent theta burst stimulationAlzheimer's disease (AD) is a progressive neurodegenerative condition affecting 6.2 million individuals in the United States, resulting in an annual cost of care of $305 billion. AD is functionally characterized by progressive degeneration of large-scale brain networks (LSBNs), including the default mode network (DMN) presumably from the deposition of amyloid plaques and neurofibrillary tangles. Available FDA-approved medications for AD such as donepezil and memantine offer limited benefit and modest impact on quality of life. In combination with resting state functional MRI (rs-fMRI), transcranial magnetic stimulation (TMS) with intermittent theta burst stimulation (iTBS) offers a non-invasive alternative to pharmacotherapy in persons with AD. We propose a pilot trial using rs-fMRI to target dysfunctional LSBNs in early stage AD. | Myopathies | Phase 3 | Traitement symptomatique | United States | À vérifier |
Essais cliniques
5| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Intermittent theta burst stimulation | Myopathies | Phase 3 | NCT07158567 | Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT | NOT_YET_RECRUITING |
| NervioX-2400 | Parkinson | Non applicable | NCT06980935 | STN-tTIS Modulates Parkinson Motor Symptoms With and Without Medications | COMPLETED |
| Intermittent theta burst stimulation | Parkinson | Non applicable | NCT05445505 | Neuroprotective Effects of iTBS in PD | UNKNOWN |
| 3D-printed non-coplanar template | Cancer | NA | NCT03882866 | Iodine-125 Seed Implantation Therapy for Locally Advanced Pancreatic Cancer | UNKNOWN |
| Intermittent theta burst stimulation | Alzheimer | NA | NCT05292222 | Transmagnetic Stimulation Pilot in Early Stage Alzheimer's Disease | COMPLETED |
Publications
16| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| 3D-printed coplanar template | Preliminary application of 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. | World journal of gastroenterology | ||
| 3D-printed non-coplanar template | Comparative study for CT-guided I seed implantation assisted by modified and conventional 3D printing non-coplanar template in malignant tumors. | BMC medical imaging | ||
| Intermittent theta burst stimulation | Adjunctive intermittent theta-burst stimulation for first-episode schizophrenia: A randomized clinical trial. | Psychiatry research | ||
| Intermittent theta burst stimulation | Does cathodal HD-tDCS-preconditioned iTBS over the contralesional dorsal premotor cortex improve upper limb motor function in patients with severe ischaemic stroke? A study protocol for a single-centre, participant-blinded and outcome assessor-blinded randomised controlled trial. | BMJ open | ||
| Intermittent theta burst stimulation | Individualized prediction of heroin cue-induced craving using task-based EEG functional connectivity. | NPJ digital medicine | ||
| Intermittent theta burst stimulation | Intermittent theta burst stimulation modulates mirror visual feedback-induced rhythm suppression for hemiparetic upper extremity recovery after stroke. | Journal of neuroengineering and rehabilitation | ||
| Intermittent theta burst stimulation | Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis. | Pain and therapy | ||
| Intermittent theta burst stimulation | Functional near-infrared spectroscopy study of intermittent theta burst stimulation on lower-limb motor dysfunction in patients with post-stroke hemiplegia. | Frontiers in human neuroscience | ||
| 3D-printed non-coplanar template | A cloud model and data envelopment analysis-enhanced FMEA framework for risk assessment in 3D-printed template-assisted brachytherapy. | Medical physics | ||
| 3D-printed non-coplanar template | A rapid semi-automated trajectory planning method for non-coplanar interstitial brachytherapy in cervical cancer using a greedy algorithm. | Radiation oncology (London, England) | ||
| 3D-printed coplanar template | Comparative study for CT-guided I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer. | Journal of contemporary brachytherapy | ||
| 3D-printed coplanar template | Interstitial I Brachytherapy as a Salvage Treatment for Refractory Cervical Lymph Node Metastasis of Thoracic Esophageal Squamous Cell Carcinoma After External Irradiation With a CT-Guided Coplanar Template-Assisted Technique: A Retrospective Study. | Technology in cancer research & treatment | ||
| Intermittent theta burst stimulation | Intermittent Theta-Burst Stimulation and Depressive Symptoms in Major Depressive Disorder: A Randomized Clinical Trial. | JAMA network open | ||
| Intermittent theta burst stimulation | Intermittent Theta-Burst Stimulation for Depression-Delineating Specific and Nonspecific Effects. | JAMA network open | ||
| Intermittent theta burst stimulation | Efficacy of non-invasive brain stimulation in Alzheimer's disease: An umbrella review of meta-analyses. | Neuroscience and biobehavioral reviews | ||
| Intermittent theta burst stimulation | Intermittent theta burst stimulation enhances the efficacy of brain-computer interface in upper limb rehabilitation post-stroke. | Frontiers in neurology |