Montefiore Medical Center — Biomedical Watch V2

Traitements8programmes

Essais4liés

Publications7liées

SourceDBlocale

Traitements

8

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
ECHOS — Engagement in CHildhood-Onset Systemic LupusThe goal of this observational (Aim 1) and pilot study (Aim 2) is to better understand how depression symptoms may contribute to how well adolescent and young adults with lupus follow-up with their lupus clinical care. The main questions the overall study attempts to answer are: 1. Whether anhedonia (a core symptom of depression) predicts disengagement in care 2. Whether a patient-tailored mobile health application built to improve both engagement in care and depression symptoms will be feasible and acceptable to adolescents and young adults with lupus. Participants with systemic lupus, ages 15-24 from the Bronx, New York will be asked to complete questionnaires; some will be asked to participate in focus groups to help adapt the mobile health app; participants will also be invited to join a pilot study to try the mobile health app for 6 months and answer questionnaires to document the experience.	Lupus	Non applicable	Traitement symptomatique	United States	À vérifier
Enhancing Cancer Care: RestoreMe App for Personalized Nutrition and Activity in Cancer PatientsThis is a single institution feasibility study of the updated RestoreMe app. The investigators plan to recruit 150 participants to this study with participants being recruited either prior to the initiation of their curative treatment or during and after completion of their cancer therapy. This design will allow the investigators to assess the feasibility of using the RestoreMe app in both the active treatment setting and follow up/survivorship setting. Information gathered from this feasibility study will inform future trial design for prospective intervention using the RestoreMe app.	Cancer	Non applicable	À vérifier		À vérifier
Prospective ED Headache Cohort StudyThe purpose of this study is to determine how often headaches recur and to learn how to predict continued suffering from headache after emergency department discharge.	Migraine	À vérifier	À vérifier	United States	À vérifier
Understanding the Pathophysiology of Migraine PainMigraine is the most common headache disorder, prevalent in 18% of females and 6% of males. Emergency room visits, physician consults, hospitalizations, medications, and indirect costs such as lost work days and decreased productivity place the global economic burden of migraines at over 20 billion dollars. It is prevalent in 28 million people in the US alone. Symptoms include unilateral, throbbing, debilitating headache pain accompanied by nausea, vomiting, photophobia, and phonophobia. Upwards of 75% of migraine patients have reduced functionability, have lost time at work, and 1/3 of patients require bed rest to manage the symptoms. The health-related impact on quality of life was comparable with that experienced by patients with congestive heart failure, hypertension, or diabetes. While the burden of migraines on our society is clear, the pathophysiology of migraines remains largely unknown. The trigeminovascular system, including the external and internal carotid arteries and their associated sensory fibers which subserve the head have long been implicated in the pain and cutaneous allodynia experienced by migraine patients. Wolff in 1953, was the first to posit that migraine headache pain is the caused by dilation or circumferential expansion of the extracranial carotid artery. He demonstrated that migraineurs had twice the pulse amplitude in their external carotid arteries compared to control subjects and these changes were directly correlated to migraine symptoms. In a 2008 study, randomized migraineurs received nitroglycerin via peripheral IV or placebo for 20 minutes prior to obtaining magnetic resonance angiography (MRA). Nitroglycerin, a potent dilator of blood vessels, reliably induced migraine-like pain in up to 80% of patients, and transient dilation of vessels of up to nearly 40%, mostly in the extracranial vessels. Sumatriptan's efficacy in migraine relief provides further evidence for this theory, as it is a selective extracranial vessel constrictor which does not cross the blood brain barrier. The goal of this current work is to utilize the direct, real-time angiography, which provides a high resolution map of vasculature, and demonstrate changes in vessel flow in patients who have migraine headache attacks. This information may guide therapeutic interventions in the future in order to better treat these migraine patients.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
Prospective ED Headache Cohort StudyThe purpose of this study is to determine how often headaches recur and to learn how to predict continued suffering from headache after emergency department discharge.	Migraine	À vérifier	À vérifier	United States	À vérifier
Understanding the Pathophysiology of Migraine PainMigraine is the most common headache disorder, prevalent in 18% of females and 6% of males. Emergency room visits, physician consults, hospitalizations, medications, and indirect costs such as lost work days and decreased productivity place the global economic burden of migraines at over 20 billion dollars. It is prevalent in 28 million people in the US alone. Symptoms include unilateral, throbbing, debilitating headache pain accompanied by nausea, vomiting, photophobia, and phonophobia. Upwards of 75% of migraine patients have reduced functionability, have lost time at work, and 1/3 of patients require bed rest to manage the symptoms. The health-related impact on quality of life was comparable with that experienced by patients with congestive heart failure, hypertension, or diabetes. While the burden of migraines on our society is clear, the pathophysiology of migraines remains largely unknown. The trigeminovascular system, including the external and internal carotid arteries and their associated sensory fibers which subserve the head have long been implicated in the pain and cutaneous allodynia experienced by migraine patients. Wolff in 1953, was the first to posit that migraine headache pain is the caused by dilation or circumferential expansion of the extracranial carotid artery. He demonstrated that migraineurs had twice the pulse amplitude in their external carotid arteries compared to control subjects and these changes were directly correlated to migraine symptoms. In a 2008 study, randomized migraineurs received nitroglycerin via peripheral IV or placebo for 20 minutes prior to obtaining magnetic resonance angiography (MRA). Nitroglycerin, a potent dilator of blood vessels, reliably induced migraine-like pain in up to 80% of patients, and transient dilation of vessels of up to nearly 40%, mostly in the extracranial vessels. Sumatriptan's efficacy in migraine relief provides further evidence for this theory, as it is a selective extracranial vessel constrictor which does not cross the blood brain barrier. The goal of this current work is to utilize the direct, real-time angiography, which provides a high resolution map of vasculature, and demonstrate changes in vessel flow in patients who have migraine headache attacks. This information may guide therapeutic interventions in the future in order to better treat these migraine patients.	Migraine	Non applicable	Traitement symptomatique	United States	À vérifier
ECHOS — Engagement in CHildhood-Onset Systemic LupusThe goal of this observational (Aim 1) and pilot study (Aim 2) is to better understand how depression symptoms may contribute to how well adolescent and young adults with lupus follow-up with their lupus clinical care. The main questions the overall study attempts to answer are: 1. Whether anhedonia (a core symptom of depression) predicts disengagement in care 2. Whether a patient-tailored mobile health application built to improve both engagement in care and depression symptoms will be feasible and acceptable to adolescents and young adults with lupus. Participants with systemic lupus, ages 15-24 from the Bronx, New York will be asked to complete questionnaires; some will be asked to participate in focus groups to help adapt the mobile health app; participants will also be invited to join a pilot study to try the mobile health app for 6 months and answer questionnaires to document the experience.	Lupus	Non applicable	Traitement symptomatique	United States	À vérifier
Enhancing Cancer Care: RestoreMe App for Personalized Nutrition and Activity in Cancer PatientsThis is a single institution feasibility study of the updated RestoreMe app. The investigators plan to recruit 150 participants to this study with participants being recruited either prior to the initiation of their curative treatment or during and after completion of their cancer therapy. This design will allow the investigators to assess the feasibility of using the RestoreMe app in both the active treatment setting and follow up/survivorship setting. Information gathered from this feasibility study will inform future trial design for prospective intervention using the RestoreMe app.	Cancer	Non applicable	À vérifier		À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
Enhancing Cancer Care: RestoreMe App for Personalized Nutrition and Activity in Cancer Patients	Cancer	Non applicable	NCT07575685	Enhancing Cancer Care: RestoreMe App for Personalized Nutrition and Activity in Cancer Patients	NOT_YET_RECRUITING
ECHOS — Engagement in CHildhood-Onset Systemic Lupus	Lupus	Non applicable	NCT05693571	ECHOS — Engagement in CHildhood-Onset Systemic Lupus	ACTIVE_NOT_RECRUITING
Understanding the Pathophysiology of Migraine Pain	Migraine	Non applicable	NCT03026101	Understanding the Pathophysiology of Migraine Pain	TERMINATED
Prospective ED Headache Cohort Study	Migraine	À vérifier	NCT00313703	Prospective ED Headache Cohort Study	COMPLETED

Publications

7

Molécule	Indication / population	Titre	Journal	Date
Understanding the Pathophysiology of Migraine Pain		[Migraine in men: biological, psychosocial and clinical characteristics].	Schmerz (Berlin, Germany)
Understanding the Pathophysiology of Migraine Pain		The influence of chronotype on pain: a systematic review and meta-analysis.	Pain
Understanding the Pathophysiology of Migraine Pain		Comprehensive MRI analysis of olfactory bulb morphology and olfactory sulcus depth in chronic rhinosinusitis, migraine, and post-COVID patients.	Neuroscience
Prospective ED Headache Cohort Study		Cumulative red flag count as a predictor of intracranial pathology in pediatric emergency headache: A threshold-based analysis.	Brain & development
Prospective ED Headache Cohort Study		Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study.	Diabetologia
Prospective ED Headache Cohort Study		Retinal layers prognosticate cognitive progression independent of relapse activity in multiple sclerosis.	Journal of neurology
Prospective ED Headache Cohort Study		Evaluating clinical associations of immediate post-traumatic headache: a prospective multicenter study.	The journal of headache and pain