María Belén Martínez Luna — Biomedical Watch V2

Traitements1programmes

Essais1liés

Publications2liées

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Traitements

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Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Focal Extracorporeal Shock Wave Therapy (ESWT)Spastic equinovarus foot is the most common lower limb motor impairment after stroke and has a significant impact on gait, mobility, and quality of life. Botulinum toxin type A (BoNT-A) is considered the first-line treatment for focal post-stroke spasticity. Extracorporeal shock wave therapy (ESWT) has shown promising results as an adjunctive treatment; however, the optimal timing for its administration in combination with BoNT-A remains unknown. This prospective, randomized, evaluator-blinded clinical trial aims to determine whether focal ESWT administered before or after BoNT-A injection is more effective than BoNT-A alone in patients with chronic post-stroke spastic equinovarus foot. Sixty-nine participants will be randomly allocated to one of three treatment groups: (1) BoNT-A alone; (2) one session of focal ESWT immediately before BoNT-A injection; or (3) one session of focal ESWT two weeks after BoNT-A injection. The primary outcome is spasticity measured with the Modified Ashworth Scale (MAS). Secondary outcomes include the Modified Tardieu Scale, passive ankle range of motion, muscle strength (MRC), 10-Meter Walk Test (10MWT), Functional Ambulation Classification (FAC), pain (VAS), Patient-Specific Assessment Scale (PSAS), muscle echogenicity using the Heckmatt scale, and muscle stiffness assessed by real-time elastography. Assessments will be performed at baseline and during follow-up through week 54.	Myopathies	Non applicable	Traitement symptomatique	Spain	À vérifier

Essais cliniques

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Molécule	Indication / population	Phase	NCT	Titre	Statut
Botulinum toxin type A	Myopathies	Non applicable	NCT07758322	Efficacy of Focused Shock Wave Therapy Before and After Botulinum Toxin Injection in Patients With Post-Stroke Spastic Equinus/Equinovarus Foot: A Randomized Clinical Trial	ACTIVE_NOT_RECRUITING

Publications

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Molécule	Indication / population	Titre	Journal	Date
Focal Extracorporeal Shock Wave Therapy (ESWT)		Extracorporeal shockwave therapy in tissue repair and regeneration.	Wiener medizinische Wochenschrift (1946)
Focal Extracorporeal Shock Wave Therapy (ESWT)		Estimating the Minimal Detectable Change (MDC) of the Disability of the Arm, Shoulder and Hand (DASH) scale in idiopathic frozen shoulder.	Orthopaedics & traumatology, surgery & research : OTSR