Fiche société
Kyowa Kirin, Inc.
Traitements, essais et publications liés.
Traitements4programmes
Essais2liés
Publications3liées
SourceDBlocale
Traitements
4| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| istradefyllineThe primary objective of this study was to establish the long-term tolerability and safety of istradefylline treatment in subjects with Parkinson's disease treated with levodopa/carbidopa. In addition, treatment response and maintenance of response were assessed. | Parkinson | Phase 2 | À vérifier | United States | À vérifier |
| KW-6002 (istradefylline)12-week, double-blind, placebo-controlled, multicenter, randomized study designed to evaluate the safety and efficacy of 40 mg/day istradefylline compared with placebo in subjects with OFF phenomena advanced PD who were treated with levodopa/carbidopa. | Parkinson | Phase 2 | À vérifier | United States | À vérifier |
| istradefyllineThe primary objective of this study was to establish the long-term tolerability and safety of istradefylline treatment in subjects with Parkinson's disease treated with levodopa/carbidopa. In addition, treatment response and maintenance of response were assessed. | Parkinson | Phase 2 | À vérifier | United States | À vérifier |
| KW-6002 (istradefylline)12-week, double-blind, placebo-controlled, multicenter, randomized study designed to evaluate the safety and efficacy of 40 mg/day istradefylline compared with placebo in subjects with OFF phenomena advanced PD who were treated with levodopa/carbidopa. | Parkinson | Phase 2 | À vérifier | United States | À vérifier |
Essais cliniques
2| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| KW-6002 (istradefylline) | Parkinson | Phase 2 | NCT00456586 | 12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa | COMPLETED |
| istradefylline | Parkinson | Phase 2 | NCT00955045 | A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy | COMPLETED |
Publications
3| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| istradefylline | Adenosine A receptor activation in the nucleus accumbens decreases motivation for wheel running in male mice. | Psychopharmacology | ||
| istradefylline | Cannabinoid and adenosine A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis. | British journal of pharmacology | ||
| istradefylline | Electronic structure-activity relationships of adenine-based istradefylline derivatives investigated by DFT, topological analysis, and exploratory neuronal excitability modeling. | Scientific reports |