Istanbul University - Cerrahpasa — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications3liées

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Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Inspiratory Muscle Training in Individuals With Multiple SclerosisMultiple sclerosis (MS) is a chronic disease affecting the central nervous system, characterized by inflammation, demyelination, and axonal degeneration, and primarily affects young adults. Muscle weakness, sensory disturbances, spasticity, pain, visual impairment, ataxia, fatigue, cognitive dysfunction, and respiratory complications are among the most commonly reported symptoms in individuals with MS. Although inspiratory muscle training has been shown to have beneficial effects in individuals with MS, the effects of different inspiratory muscle training intensities on respiratory muscle strength and pulmonary function have not been sufficiently investigated. The primary aim of this study is to investigate the effectiveness and clinical feasibility of high-intensity interval inspiratory muscle training in individuals with MS. The secondary aim is to compare the effects of high-intensity interval inspiratory muscle training, low-intensity inspiratory muscle training, and conventional rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, lower extremity functional muscle strength, balance, fatigue, dysphagia severity, sleep quality, and quality of life in individuals with MS. Participants will be randomly assigned to one of three groups: a high-intensity interval inspiratory muscle training group, a low-intensity inspiratory muscle training group, or a conventional rehabilitation group. All three groups will receive conventional rehabilitation, while the inspiratory muscle training groups will additionally receive their respective inspiratory muscle training programs. This study aims to be the first randomized controlled trial to evaluate the effects of high-intensity interval inspiratory muscle training in individuals with MS.	SEP	NA	Traitement symptomatique		À vérifier
The Effect of Low-İntensity Combined Exercises in Patients With Early Stage ALS.Description non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	NA	Traitement symptomatique	Turkey (Türkiye)	À vérifier
The Effect of Low-İntensity Combined Exercises in Patients With Early Stage ALS.Description non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé.	Sclérose latérale amyotrophique	NA	Traitement symptomatique	Turkey (Türkiye)	À vérifier
Inspiratory Muscle Training in Individuals With Multiple SclerosisMultiple sclerosis (MS) is a chronic disease affecting the central nervous system, characterized by inflammation, demyelination, and axonal degeneration, and primarily affects young adults. Muscle weakness, sensory disturbances, spasticity, pain, visual impairment, ataxia, fatigue, cognitive dysfunction, and respiratory complications are among the most commonly reported symptoms in individuals with MS. Although inspiratory muscle training has been shown to have beneficial effects in individuals with MS, the effects of different inspiratory muscle training intensities on respiratory muscle strength and pulmonary function have not been sufficiently investigated. The primary aim of this study is to investigate the effectiveness and clinical feasibility of high-intensity interval inspiratory muscle training in individuals with MS. The secondary aim is to compare the effects of high-intensity interval inspiratory muscle training, low-intensity inspiratory muscle training, and conventional rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, lower extremity functional muscle strength, balance, fatigue, dysphagia severity, sleep quality, and quality of life in individuals with MS. Participants will be randomly assigned to one of three groups: a high-intensity interval inspiratory muscle training group, a low-intensity inspiratory muscle training group, or a conventional rehabilitation group. All three groups will receive conventional rehabilitation, while the inspiratory muscle training groups will additionally receive their respective inspiratory muscle training programs. This study aims to be the first randomized controlled trial to evaluate the effects of high-intensity interval inspiratory muscle training in individuals with MS.	SEP	NA	Traitement symptomatique		À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
Inspiratory Muscle Training in Individuals With Multiple Sclerosis	SEP	NA	NCT07672535	Inspiratory Muscle Training in Individuals With Multiple Sclerosis	NOT_YET_RECRUITING
The Effect of Low-İntensity Combined Exercises in Patients With Early Stage ALS.	Sclérose latérale amyotrophique	NA	NCT05716074	The Effect of Low-İntensity Combined Exercises in Patients With Early Stage ALS.	UNKNOWN

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Inspiratory Muscle Training in Individuals With Multiple Sclerosis		Effects of Respiratory Muscle Training on Respiratory Function and Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.	Multiple sclerosis and related disorders
Inspiratory Muscle Training in Individuals With Multiple Sclerosis		Effects of respiratory muscle training on respiratory function, exercise capacity and quality of life in people with multiple sclerosis: a systematic review and meta-analysis.	Multiple sclerosis and related disorders
Inspiratory Muscle Training in Individuals With Multiple Sclerosis		Effects of respiratory muscle training on respiratory function, trunk control and fatigue in multiple sclerosis.	Scientific reports