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Istanbul Medipol University Hospital
Traitements, essais et publications liés.
Traitements3programmes
Essais1liés
Publications24liées
SourceDBlocale
Traitements
3| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Metabolic Cofactor SupplementationThis double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate, nicotinamide riboside and serine. Concomitant use of pivotal metabolic cofactors via simultaneous dietary supplementation will stimulate to enhance hepatic β-oxidation and this study's hypothesis is that this will result in increased mitochondrial activity in human brain cell-types. | Alzheimer, Parkinson | Phase 2 | Remyélinisation indirecte / réparation | Turkey (Türkiye) | À vérifier |
| SorbitolThis double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate, nicotinamide riboside and serine. Concomitant use of pivotal metabolic cofactors via simultaneous dietary supplementation will stimulate to enhance hepatic β-oxidation and this study's hypothesis is that this will result in increased mitochondrial activity in human brain cell-types. | Alzheimer, Parkinson | Phase 2 | Remyélinisation indirecte / réparation | Turkey (Türkiye) | À vérifier |
| Metabolic Cofactor SupplementationThis double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate, nicotinamide riboside and serine. Concomitant use of pivotal metabolic cofactors via simultaneous dietary supplementation will stimulate to enhance hepatic β-oxidation and this study's hypothesis is that this will result in increased mitochondrial activity in human brain cell-types. | Parkinson | Phase 2 | Remyélinisation indirecte / réparation | Turkey (Türkiye) | À vérifier |
Essais cliniques
1| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Metabolic Cofactor Supplementation | Parkinson | Phase 2 | NCT04044131 | Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients | COMPLETED |
Publications
24| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Sorbitol | A wax-printed Janus paper-based microfluidic wearable sensor for metabolic analysis in sweat. | Biosensors & bioelectronics | ||
| Sorbitol | Glycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes. | Medical gas research | ||
| Sorbitol | Pharmaceutical development of composition of effervescent tablets with acetylsalicylic acid, paracetamol, and ascorbic acid. | Pharmaceutical science advances | ||
| Metabolic Cofactor Supplementation | Multi-walled carbon nanotube buckypaper with covalently bound NAD and immobilized glucose dehydrogenase for reagentless glucose biosensing. | Talanta | ||
| Metabolic Cofactor Supplementation | Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling. | Bioresource technology | ||
| Metabolic Cofactor Supplementation | UHPLC-Q-Exactive Orbitrap MS-based brain-gut metabolomics implicates multi-pathway modulation by Ginseng stem-leaf saponins in chronic fatigue syndrome mice. | Journal of pharmaceutical and biomedical analysis | ||
| Sorbitol | A Comparative Evaluation of Xylitol, Sorbitol, and Isomalt-containing Candies and Their Effects on Salivary pH and Salivary Flow Rate in Children Aged 6-12 Years: An Study. | International journal of clinical pediatric dentistry | ||
| Sorbitol | Lactate dehydrogenase A exhibits sorbitol/fructose-related catalytic activity and contributes to polyol pathway metabolism in tumor cells. | Frontiers in endocrinology | ||
| Sorbitol | Epidemiology, Diversity, Physiology, and Chemical Management of Rhizoctonia solani Causing Web Blight in Country Bean. | Journal of basic microbiology | ||
| Metabolic Cofactor Supplementation | Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways. | Journal of Yeungnam medical science | ||
| Metabolic Cofactor Supplementation | Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. | Cell proliferation | ||
| Sorbitol | Genotoxic and Cytotoxic Potential of Food Sweeteners D-Sorbitol and the Mixtures of D-Sorbitol and Xylitol in Human Lymphocytes. | Journal of applied toxicology : JAT | ||
| Sorbitol | Molecular Dynamics Simulation of Sorbitol-Based Surfactants with Different Chiral Configurations at the Gas/Liquid Interface. | Langmuir : the ACS journal of surfaces and colloids | ||
| Metabolic Cofactor Supplementation | Pyridoxine/pyridoxal-5'-phosphate repletion to improve outcomes of alcohol withdrawal syndrome and promote long-term abstinence: a hypothesis. | Clinical toxicology (Philadelphia, Pa.) | ||
| Sorbitol | A role for the syntaxin protein in post-wound cell survival. | Molecular biology of the cell | ||
| Sorbitol | Belgian endive-derived biostimulant activity in , lettuce, and sweet pepper at different developmental stages, environmental conditions, and application methods. | Frontiers in plant science | ||
| Sorbitol | A Multifunctional Electrocatalyst for Formate Production with Concurrent Hydrogen Evolution and Electrochemical Hydrogenation of Glucose to Sorbitol. | ACS applied materials & interfaces | ||
| Sorbitol | Strain-Sensitive Double-Network Organogel With Strong Adhesion for Movement Monitoring. | Macromolecular rapid communications | ||
| Metabolic Cofactor Supplementation | CIA5 and its interacting metal-binding GTPase ZNG3 are degraded by the proteasome in Zn deficiency. | The Plant journal : for cell and molecular biology | ||
| Sorbitol | Radial Branch Hydraulics and Cellular Injury Thresholds in Poplar: Insights from Controlled Dehydration and High-resolution Dendrometry. | Tree physiology | ||
| Sorbitol | Detection and Zoonotic Implications of Shiga Toxin-Producing Escherichia coli in Black Bengal Goats in Bangladesh. | Veterinary medicine and science | ||
| Sorbitol | Luseogliflozin restores GIP responsiveness in diabetic male mice with preserved β-cell function. | Physiological reports | ||
| Metabolic Cofactor Supplementation | Effects of Bifidobacterium animalis ssp. lactis IU100 and resistant starch type III on texture and flavor of fermented milk during storage. | Journal of dairy science | ||
| Metabolic Cofactor Supplementation | mZVI-Enhanced Mixed Nitrogen Removal in Klebsiella oxytoca via Coordinated Electron Transfer and Metabolic Reprogramming. | Biotechnology and bioengineering |