Icure Pharmaceutical Inc. — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications15liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
DonepezilStudy of the Safety, tolerability and pharmacokinetics with multiple doses of donepezil patch in healthy male subjects	Alzheimer	Phase 1	À vérifier	South Korea	À vérifier
DonepezilStudy of the Safety, tolerability and pharmacokinetics with multiple doses of donepezil patch in healthy male subjects	Alzheimer	Phase 1	À vérifier	South Korea	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Donepezil	Alzheimer	Phase 1	NCT02178124	A Phase I Clinical Study, Randomized, Single-blind, Placebo-controlled, Multiple Doses, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects.	COMPLETED

Publications

15

Molécule	Indication / population	Titre	Journal	Date
Donepezil		Neuroprotective effects of aqueous extract of Pterocarpus mildbraedii Harms. on some biochemical markers in Alzheimer's disease using an AlCl-induced rat model: Integrated ADMET, network pharmacology, molecular docking, and in vivo experimental validation.	Journal of ethnopharmacology
Donepezil		Mechanisms of electroacupuncture for the treatment of Alzheimer's disease by activating Wnt/β-catenin pathway to improve blood-brain barrier function.	IBRO neuroscience reports
Donepezil		Chrono-Nanomedicine at the Barrier: Circadian Rhythms Influence the Delivery of Donepezil Across the BCSFB.	International journal of molecular sciences
Donepezil		CellSwarm-AD: A Multi-Scale Agent-Based Framework for Virtual Alzheimer's Disease Trials.	International journal of molecular sciences
Donepezil		Valorization of 2-aminoethoxydiphenyl borate as a neurotherapeutic agent: modulation of calcineurin, TRPC1 and MARK2/GSK-3β signaling in scopolamine-triggered tauopathy.	Inflammopharmacology
Donepezil		Daturaolone from L. Inhibits acetylcholinesterase and monoamine oxidase B.	Natural product research
Donepezil		Design, synthesis, biological evaluation, and in silico analysis of novel coumarin carboxamides as acetylcholinesterase and butyrylcholinesterase inhibitors and anticancer agents.	Journal of computer-aided molecular design
Donepezil		Donepezil-induced manic episodes in two patients with different types of dementia.	Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi
Donepezil		Rational design and synthesis of dispiroindene-pyrrolidinedione scaffolds as multi-target directed ligands: potent AChE inhibitors with antioxidant activity and favorable biocompatibility in SH-SY5Y cells.	Bioorganic chemistry
Donepezil		Hospitalization for Malignant Arrhythmias Following Initiation of Donepezil: A Retrospective Cohort Study.	Pharmacoepidemiology and drug safety
Donepezil		Predicting drug release from polymeric long-acting injectables using a machine learning approach to decode formulation-performance relationships.	Drug delivery and translational research
Donepezil		RGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model.	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Donepezil		Synthesis, characterization, and biocompatibility evaluation of donepezil-loaded magnetite-PLGA nanoparticles in neuroblastoma cells.	Scientific reports
Donepezil		EphB1-Mediated Transient Blood-Brain Barrier Opening Facilitates a Ferritin-Based Nanotherapeutic for Alzheimer's Disease.	Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Donepezil		Post Hoc Subgroup Analysis by Disease Severity in a Non-Inferiority Trial of Donepezil 27.5 mg Transdermal Formulation in Japanese Patients With Mild-to-Moderate Alzheimer Disease.	Alzheimer disease and associated disorders