Icahn School of Medicine at Mount Sinai — Biomedical Watch V2

Traitements11programmes

Essais5liés

Publications16liées

SourceDBlocale

Traitements

11

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
GCHD- Nepal — Group-Care for Hypertension and Diabetes Management in NepalHypertension and diabetes represent significant and growing public health challenges in Nepal, particularly in underserved communities. Traditional individual-based care approaches may not adequately address the multifaceted needs of patients with these chronic conditions in resource-limited settings. The group care model, which combines peer support, education, and clinical care, offers a promising alternative that could enhance patient outcomes. This protocol outlines a dual cluster randomized controlled trial (DRCT) using a hybrid type II design to evaluate the effectiveness of a group care model for improving the control and management of hypertension and diabetes in four municipalities in Nepal. The trial will also evaluate the implementation outcomes of fidelity and economic costs. The researchers will assess the effect of the group care model on clinical outcomes. The primary outcomes will be the proportion of patients with controlled versus uncontrolled blood pressure (among patients with hypertension) and the proportion of patients with controlled versus uncontrolled hemoglobin A1c (among patients with diabetes) at 6 and 12 months. The researchers will conduct a three-arm comparison (control vs. low intensity strategies vs. high intensity strategies), with additional pairwise contrasts to examine differences in effectiveness. The researchers will also evaluate intervention fidelity in the two intervention groups and conduct an economic analysis. Each cluster, representing a health facility, will be randomly allocated to one of the three arms after baseline data collection and prior to initiating the intervention phase. The low intensity arm will receive the group care model with standard implementation support, while the high intensity arm will receive the group care model with enhanced implementation strategies. The control arm will continue with the standard of care offered in the nearest health facility, including hypertension and diabetes detection and management based on PEN protocols 1 and 2. After study completion, control facilities will be offered training on the group care model.	Hypertension	Non applicable	À vérifier	Nepal	À vérifier
Lighting Intervention TherapyThe purpose of this research study is to investigate the effect of a light treatment on sleep, memory and brain function. In people with mild cognitive impairment (MCI) and Alzheimer's disease, sleep-wake disturbance is evident in up to 60% of patients. This can be caused by disruption of circadian rhythms and may affect our health and well-being. Circadian rhythms are the natural cycle of physical, mental, and behavior changes that the body goes through in a 24-hour cycle. Circadian rhythms are mostly affected by light and darkness and are controlled by a small area in the middle of the brain. They can affect sleep, body temperature, hormones, appetite, and other body functions. The circadian system plays an important role in the body and can affect sleep and brain function. The results of the research would help develop light-delivery methods to improve sleep and memory in patients with mild cognitive impairment (MCI) and Alzheimer's disease who typically spend a significant amount of time indoors.	Alzheimer	NA	À vérifier	United States	À vérifier
Radiation SegmentectomyThe aim of this pilot study is to assess the efficacy of radiation segmentectomy with Theraspheres in patients with unresectable hepatocellular carcinoma that would qualify for thermal ablation as per the BCLC guidelines, but are unable to receive thermal ablation due to unfavorable location of target lesions.	Cancer	Non applicable	À vérifier	United States	À vérifier
SeizEARDetermine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG). The study team anticipates enrolling five healthy participants through meeting announcements and a research email list serv in the Neurology Dept. Based on the appropriate positive initial test of healthy individuals, test the in-ear device on 10 participants with seizures or suspected seizures scheduled for a clinical scalp EEG test.	Épilepsie	Non applicable	À vérifier	United States	À vérifier
Sham LITThe purpose of this research study is to investigate the effect of a light treatment on sleep, memory and brain function. In people with mild cognitive impairment (MCI) and Alzheimer's disease, sleep-wake disturbance is evident in up to 60% of patients. This can be caused by disruption of circadian rhythms and may affect our health and well-being. Circadian rhythms are the natural cycle of physical, mental, and behavior changes that the body goes through in a 24-hour cycle. Circadian rhythms are mostly affected by light and darkness and are controlled by a small area in the middle of the brain. They can affect sleep, body temperature, hormones, appetite, and other body functions. The circadian system plays an important role in the body and can affect sleep and brain function. The results of the research would help develop light-delivery methods to improve sleep and memory in patients with mild cognitive impairment (MCI) and Alzheimer's disease who typically spend a significant amount of time indoors.	Alzheimer	NA	À vérifier	United States	À vérifier
WTC Chest CT Imaging ArchiveDr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016. The clinical team sought to assess all findings suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate those findings with clinical, functional, and exposure indicators. The study team's research will also involve analyses of longitudinal imaging and functional trends, and characterization of the WTC related lower airway diseases and their risk factors, with a focus on obesity-related imaging markers. The study team also plans to characterize the transitions into chronic obstructive pulmonary disease (COPD) among these workers. The researchers also propose to test the use of added respiratory surveillance tools and explore functional markers of disease progression, explore alternate methods to investigate longitudinal functional trajectories, and novel spirometry calibration methods that might facilitate the implementation of spirometry in nonspecialized settings.	Cancer	À vérifier	Ralentissement de la progression	United States	À vérifier
Lighting Intervention TherapyThe purpose of this research study is to investigate the effect of a light treatment on sleep, memory and brain function. In people with mild cognitive impairment (MCI) and Alzheimer's disease, sleep-wake disturbance is evident in up to 60% of patients. This can be caused by disruption of circadian rhythms and may affect our health and well-being. Circadian rhythms are the natural cycle of physical, mental, and behavior changes that the body goes through in a 24-hour cycle. Circadian rhythms are mostly affected by light and darkness and are controlled by a small area in the middle of the brain. They can affect sleep, body temperature, hormones, appetite, and other body functions. The circadian system plays an important role in the body and can affect sleep and brain function. The results of the research would help develop light-delivery methods to improve sleep and memory in patients with mild cognitive impairment (MCI) and Alzheimer's disease who typically spend a significant amount of time indoors.	Alzheimer	NA	À vérifier	United States	À vérifier
WTC Chest CT Imaging ArchiveDr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016. The clinical team sought to assess all findings suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate those findings with clinical, functional, and exposure indicators. The study team's research will also involve analyses of longitudinal imaging and functional trends, and characterization of the WTC related lower airway diseases and their risk factors, with a focus on obesity-related imaging markers. The study team also plans to characterize the transitions into chronic obstructive pulmonary disease (COPD) among these workers. The researchers also propose to test the use of added respiratory surveillance tools and explore functional markers of disease progression, explore alternate methods to investigate longitudinal functional trajectories, and novel spirometry calibration methods that might facilitate the implementation of spirometry in nonspecialized settings.	Cancer	À vérifier	Ralentissement de la progression	United States	À vérifier
GCHD- Nepal — Group-Care for Hypertension and Diabetes Management in NepalHypertension and diabetes represent significant and growing public health challenges in Nepal, particularly in underserved communities. Traditional individual-based care approaches may not adequately address the multifaceted needs of patients with these chronic conditions in resource-limited settings. The group care model, which combines peer support, education, and clinical care, offers a promising alternative that could enhance patient outcomes. This protocol outlines a dual cluster randomized controlled trial (DRCT) using a hybrid type II design to evaluate the effectiveness of a group care model for improving the control and management of hypertension and diabetes in four municipalities in Nepal. The trial will also evaluate the implementation outcomes of fidelity and economic costs. The researchers will assess the effect of the group care model on clinical outcomes. The primary outcomes will be the proportion of patients with controlled versus uncontrolled blood pressure (among patients with hypertension) and the proportion of patients with controlled versus uncontrolled hemoglobin A1c (among patients with diabetes) at 6 and 12 months. The researchers will conduct a three-arm comparison (control vs. low intensity strategies vs. high intensity strategies), with additional pairwise contrasts to examine differences in effectiveness. The researchers will also evaluate intervention fidelity in the two intervention groups and conduct an economic analysis. Each cluster, representing a health facility, will be randomly allocated to one of the three arms after baseline data collection and prior to initiating the intervention phase. The low intensity arm will receive the group care model with standard implementation support, while the high intensity arm will receive the group care model with enhanced implementation strategies. The control arm will continue with the standard of care offered in the nearest health facility, including hypertension and diabetes detection and management based on PEN protocols 1 and 2. After study completion, control facilities will be offered training on the group care model.	Hypertension	Non applicable	À vérifier	Nepal	À vérifier
Radiation SegmentectomyThe aim of this pilot study is to assess the efficacy of radiation segmentectomy with Theraspheres in patients with unresectable hepatocellular carcinoma that would qualify for thermal ablation as per the BCLC guidelines, but are unable to receive thermal ablation due to unfavorable location of target lesions.	Cancer	Non applicable	À vérifier	United States	À vérifier
SeizEARDetermine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG). The study team anticipates enrolling five healthy participants through meeting announcements and a research email list serv in the Neurology Dept. Based on the appropriate positive initial test of healthy individuals, test the in-ear device on 10 participants with seizures or suspected seizures scheduled for a clinical scalp EEG test.	Épilepsie	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

5

Molécule	Indication / population	Phase	NCT	Titre	Statut
SeizEAR	Épilepsie	Non applicable	NCT07088835	SeizEAR Safety Study	RECRUITING
Radiation Segmentectomy	Cancer	Non applicable	NCT03248375	Impact of Y90 Radiation Segmentectomy on HCC	COMPLETED
GCHD- Nepal — Group-Care for Hypertension and Diabetes Management in Nepal	Hypertension	Non applicable	NCT07439380	GCHD- Nepal — Group-Care for Hypertension and Diabetes Management in Nepal	RECRUITING
WTC Chest CT Imaging Archive	Cancer	À vérifier	NCT03295279	WTC Chest CT Imaging Archive	ENROLLING_BY_INVITATION
Lighting Intervention Therapy	Alzheimer	NA	NCT05596994	7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD	COMPLETED

Publications

16

Molécule	Indication / population	Titre	Journal	Date
Sham LIT		Four-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy.	JAMA
Lighting Intervention Therapy		Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease.	Drug delivery
Lighting Intervention Therapy		Covid-19 and influenza vaccine hesitancy insights from France, Italy and Hungary: A mixed-methods study.	Human vaccines & immunotherapeutics
Lighting Intervention Therapy		Benefit of Linked-Color Imaging in Artificial Intelligence-Assisted Diagnosis of Early Gastric Cancer: A Pilot Study With Propensity Score Adjustment.	DEN open
Lighting Intervention Therapy		Real-Time Sign Language Interpretation via Customized Sign Language Gloves and Motion Retrieval.	Sensors (Basel, Switzerland)
Lighting Intervention Therapy		Can All Oxygen Molecules Accumulate in One Corner of the Room? Treating Pathological Narcissism Requires High Standard Randomized Clinical Trials. A Commentary on the Trial by Mohajerin et al.	Clinical psychology & psychotherapy
Lighting Intervention Therapy		Nurses' experiences implementing clinical practice guidelines for detecting and managing chronic kidney disease in Eswatini's primary healthcare facilities: A qualitative study.	Health SA = SA Gesondheid
Lighting Intervention Therapy		Impact assessment of effective rounds of mass drug administration against schistosomiasis and soil transmitted helminthiasis among school age children in Akwa Ibom State, Nigeria.	PLoS neglected tropical diseases
Lighting Intervention Therapy		Sedation, Analgesia, and Neuromuscular Blockade.	Clinics in chest medicine
Lighting Intervention Therapy		Comparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials.	Lasers in medical science
Lighting Intervention Therapy		Recent advances in bilirubin photoisomerization and photodegradation: in vitro and in vivo evidence for jaundice treatment.	Lasers in medical science
Lighting Intervention Therapy		Indocyanine green fluorescence kinetics during hypothermic oxygenated machine perfusion might predict graft function after liver transplantation.	Langenbeck's archives of surgery
Sham LIT		Circular eight-room maze for assessing spatial learning and memory functions in rats: An example using a traumatic brain injury model.	Computers in biology and medicine
Sham LIT		Liver antifibrosis mechanisms of oligomeric grape seed proanthocyanidins 40%: role of collagen and MMP-1 modulation.	Inflammopharmacology
Lighting Intervention Therapy		Is inpatient monitoring necessary in pediatric patients with comorbidities following routine dental procedures? A retrospective analysis.	Oral and maxillofacial surgery
Lighting Intervention Therapy		Comparative analgesic outcomes of anterior quadratus lumborum block and transversus abdominis plane block in patients undergoing laparoscopic cholecystectomy: A prospective observational study.	Medicine