IGEA — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications3liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
ElectrochemotherapyElectrochemotherapy (ECT) is a non-thermal tumour ablation modality. It consists of the local potentiation, by means of local reversible electroporation of tumour tissues, of the antitumor activity of non-permeant or poorly permeant anticancer drugs already possessing intrinsic cytotoxicity. ECT has proved to be effective in the treatment of various cutaneous tumour nodules of any origin. Mostly ECT is offered to patients in case of multiple cutaneous metastases, when they cannot be excised, due to their number or localization. This study investigate the application of ECT in the treatment of liver metastases from colorectal adenocarcinoma, for which other thermal cytoreductive methods would be risky compared to the supposed expected clinical benefits.	Cancer	Phase 1/2	À vérifier		À vérifier
ElectrochemotherapyElectrochemotherapy (ECT) is a non-thermal tumour ablation modality. It consists of the local potentiation, by means of local reversible electroporation of tumour tissues, of the antitumor activity of non-permeant or poorly permeant anticancer drugs already possessing intrinsic cytotoxicity. ECT has proved to be effective in the treatment of various cutaneous tumour nodules of any origin. Mostly ECT is offered to patients in case of multiple cutaneous metastases, when they cannot be excised, due to their number or localization. This study investigate the application of ECT in the treatment of liver metastases from colorectal adenocarcinoma, for which other thermal cytoreductive methods would be risky compared to the supposed expected clinical benefits.	Cancer	Phase 1/2	À vérifier		À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Electrochemotherapy	Cancer	Phase 1/2	NCT02709811	Safety and Feasibility of Electrochemotherapy in Unresectable Colorectal Adenocarninoma Liver Metastases	TERMINATED

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Electrochemotherapy		Electrode material and electrical delivery mode shape the mechanisms and efficacy of electrochemical tumor ablation.	Bioelectrochemistry (Amsterdam, Netherlands)
Electrochemotherapy		Time-dependent stress responses determine bleomycin electrochemotherapy efficacy in drug-resistant breast Cancer cells.	Bioelectrochemistry (Amsterdam, Netherlands)
Electrochemotherapy		Pharmacokinetics of bleomycin in dogs treated with electrochemotherapy.	The veterinary quarterly