First Affiliated Hospital of Guangxi Medical University — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications3liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Prophylactic Impacted Tooth ExtractionThis multicenter, randomized controlled trial is designed to determine whether omitting prophylactic extraction of impacted teeth before radiotherapy leads to an unacceptably higher risk of jaw osteoradionecrosis (JORN) compared with conventional prophylactic extraction in patients with non-metastatic nasopharyngeal carcinoma (NPC). JORN is a condition in which jawbone tissue is damaged and fails to heal properly after radiotherapy. A total of 536 eligible participants with at least one impacted tooth will be randomly assigned to either omit prophylactic extraction of impacted teeth before radiotherapy or undergo conventional prophylactic extraction before radiotherapy. All participants will receive standard curative-intent intensity-modulated radiotherapy (IMRT), with chemotherapy administered when indicated according to the study protocol. Participants will be followed for up to 5 years. The primary outcome is the incidence of JORN within 2 years after completion of radiotherapy. Secondary outcomes include longer-term incidence of JORN, overall survival, locoregional relapse-free survival, distant metastasis-free survival, quality of life, and treatment-related toxicities.	Cancer	Non applicable	À vérifier	China	À vérifier
Prophylactic Impacted Tooth ExtractionThis multicenter, randomized controlled trial is designed to determine whether omitting prophylactic extraction of impacted teeth before radiotherapy leads to an unacceptably higher risk of jaw osteoradionecrosis (JORN) compared with conventional prophylactic extraction in patients with non-metastatic nasopharyngeal carcinoma (NPC). JORN is a condition in which jawbone tissue is damaged and fails to heal properly after radiotherapy. A total of 536 eligible participants with at least one impacted tooth will be randomly assigned to either omit prophylactic extraction of impacted teeth before radiotherapy or undergo conventional prophylactic extraction before radiotherapy. All participants will receive standard curative-intent intensity-modulated radiotherapy (IMRT), with chemotherapy administered when indicated according to the study protocol. Participants will be followed for up to 5 years. The primary outcome is the incidence of JORN within 2 years after completion of radiotherapy. Secondary outcomes include longer-term incidence of JORN, overall survival, locoregional relapse-free survival, distant metastasis-free survival, quality of life, and treatment-related toxicities.	Cancer	Non applicable	À vérifier	China	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Prophylactic Impacted Tooth Extraction	Cancer	Non applicable	NCT07764887	Impacted Tooth Management and Osteoradionecrosis Risk in NPC	NOT_YET_RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Prophylactic Impacted Tooth Extraction		Influence of impacted mandibular third molars on pathological changes on themselves and adjacent tissues across different age groups: a cross-sectional study.	Journal of applied oral science : revista FOB
Prophylactic Impacted Tooth Extraction		Role of anesthetic techniques in trigeminocardiac reflex during oral surgery of the mandible under local anesthesia.	Journal of stomatology, oral and maxillofacial surgery
Prophylactic Impacted Tooth Extraction		Anatomical Predictors of Second Molar External Root Resorption: A Cone-Beam Computed Tomography Study of Impacted Third Molars.	International dental journal