Beni-Suef University — Biomedical Watch V2

Traitements7programmes

Essais4liés

Publications3liées

SourceDBlocale

Traitements

7

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
DexmedetomidineMigraine is a debilitating neurological disorder characterized by recurrent headaches episodes, often accompanied by amplified perception of multiple sensory inputs such as cutaneous allodynia, photophobia, and phonophobia. The suggested mechanism in migraine is likely through sensitized trigeminovascular and dysfunctional pain modulatory systems. Dexmedetomidine, a selective α2-adrenergic receptor agonist, exerts central antinociceptive effects by reducing neuronal hyperexcitability, glial activation, and CGRP expression. Nebulized administration provides a non-invasive alternative to intravenous use, with rapid CNS absorption and minimal sedation .	Migraine, SEP	Non applicable	Traitement symptomatique	Egypt	À vérifier
Doxapram HydrochlorideDoxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage. Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.	SEP	Non applicable	Immunomodulation	Egypt	À vérifier
Greater Occipital Nerve Block (GONB)Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy.	Migraine	Non applicable	À vérifier	Egypt	À vérifier
Mechanism-Based Cervical Rehabilitation for Chronic MigraineTo investigate the effectiveness of mechanism-based cervical sensorimotor rehabilitation on cervical muscle activation, cervical proprioception, and migraine burden.	Migraine	Non applicable	À vérifier		À vérifier
Mechanism-Based Cervical Rehabilitation for Chronic MigraineTo investigate the effectiveness of mechanism-based cervical sensorimotor rehabilitation on cervical muscle activation, cervical proprioception, and migraine burden.	Migraine	Non applicable	À vérifier		À vérifier
DexmedetomidineMigraine is a debilitating neurological disorder characterized by recurrent headaches episodes, often accompanied by amplified perception of multiple sensory inputs such as cutaneous allodynia, photophobia, and phonophobia. The suggested mechanism in migraine is likely through sensitized trigeminovascular and dysfunctional pain modulatory systems. Dexmedetomidine, a selective α2-adrenergic receptor agonist, exerts central antinociceptive effects by reducing neuronal hyperexcitability, glial activation, and CGRP expression. Nebulized administration provides a non-invasive alternative to intravenous use, with rapid CNS absorption and minimal sedation .	Migraine	Non applicable	Traitement symptomatique	Egypt	À vérifier
Doxapram HydrochlorideDoxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage. Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.	SEP	Non applicable	Immunomodulation	Egypt	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
Doxapram Hydrochloride	SEP	Non applicable	NCT03894189	The Effect of Doxapram Versus Theophylline on Diaphragmatic Function	UNKNOWN
Dexmedetomidine	Migraine	Non applicable	NCT07769255	Effect of Nebulized Dexmedetomidine on Central Sensitization and Chronification in Migraine	RECRUITING
Mechanism-Based Cervical Rehabilitation for Chronic Migraine	Migraine	Non applicable	NCT07762690	Mechanism-Based Cervical Rehabilitation for Chronic Migraine	NOT_YET_RECRUITING
OnabotulinumtoxinA	Migraine	Non applicable	NCT07535723	Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine	NOT_YET_RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Mechanism-Based Cervical Rehabilitation for Chronic Migraine		Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.	Pain and therapy
Greater Occipital Nerve Block (GONB)		Assessing the effectiveness of greater occipital nerve block in chronic migraine: a systematic review and meta-analysis.	BMC neurology
Greater Occipital Nerve Block (GONB)		Comparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting.	Cureus