Arizona State University — Biomedical Watch V2

Traitements4programmes

Essais2liés

Publications3liées

SourceDBlocale

Traitements

4

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
App-based Breathing Program for Migraine ReliefMigraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.	Migraine	Non applicable	À vérifier	United States	À vérifier
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT TrialThis multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease \[AD\] signature cortical thickness, and default mode network \[DMN\]) in older adults with amnestic MCI (aMCI).	Alzheimer	NA	À vérifier	United States	À vérifier
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT TrialThis multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease \[AD\] signature cortical thickness, and default mode network \[DMN\]) in older adults with amnestic MCI (aMCI).	Alzheimer	NA	À vérifier	United States	À vérifier
App-based Breathing Program for Migraine ReliefMigraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.	Migraine	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

2

Molécule	Indication / population	Phase	NCT	Titre	Statut
App-based Breathing Program for Migraine Relief	Migraine	Non applicable	NCT07297901	App-based Breathing Program for Migraine Relief	ENROLLING_BY_INVITATION
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial	Alzheimer	NA	NCT03313895	The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial	COMPLETED

Publications

3

Molécule	Indication / population	Titre	Journal	Date
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial		Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.	Aging and health research
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial		Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience.	Alzheimer's & dementia : the journal of the Alzheimer's Association
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial		Better together - efficacy of combined physical and cognitive training in young adults for enhancing physical and cognitive performance: a randomized controlled trial.	Frontiers in sports and active living