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Allogene Therapeutics
Traitements, essais et publications liés.
Traitements6programmes
Essais3liés
Publications26liées
SourceDBlocale
Traitements
6| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| ALLO-329This is a first-in-human, single-arm, open-label study evaluating the safety, tolerability, and preliminary efficacy of ALLO-329 in adults with autoimmune diseases: systemic lupus erythematosus (SLE) with and without renal involvement, idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc).The purpose of this trial is to evaluate the safety and tolerability of ALLO-329, an allogeneic anti-CD19, anti-CD70 dual chimeric antigen receptor (CAR) T cell therapy, in adults with autoimmune disorders, provide initial evidence of biological activity and clinical response to the treatment and determine the recommended Phase 2 regimen (RP2R). | Lupus, Myopathies | Phase 1 | Immunomodulation + Thérapie cellulaire | United States, Canada | À vérifier |
| CyclophosphamideThis randomized phase II trial studies how well paclitaxel with or without carboplatin and/or bevacizumab followed by doxorubicin and cyclophosphamide works in treating patients with breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as paclitaxel, carboplatin, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bevacizumab may stop the growth of tumor cells by blocking blood flow to the tumor. Giving chemotherapy together with bevacizumab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. | Cancer, Épilepsie, Lupus, Myasthénie, Myopathies, SEP | Phase 1 | À vérifier | United States, Canada | À vérifier |
| FludarabineThe purpose of this study is to assess the safety, tolerability, and clinical activity of KYV 101 (a fully-human anti-CD19 CAR T-cell therapy) in adult subjects with B cell-driven autoimmune diseases. The trial anticipates enrolling participants to reach a maximum of 24 participants who will receive 1 dose of KYV-101 and will be followed for 2 years. | Cancer, Lupus, Myasthénie, Myopathies, SEP | Phase 1 | Immunomodulation + Thérapie cellulaire | United States, Canada | À vérifier |
| CyclophosphamideThis randomized phase II trial studies how well paclitaxel with or without carboplatin and/or bevacizumab followed by doxorubicin and cyclophosphamide works in treating patients with breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as paclitaxel, carboplatin, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bevacizumab may stop the growth of tumor cells by blocking blood flow to the tumor. Giving chemotherapy together with bevacizumab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. | Lupus | NA | À vérifier | Brazil | À vérifier |
| ALLO-329This is a first-in-human, single-arm, open-label study evaluating the safety, tolerability, and preliminary efficacy of ALLO-329 in adults with autoimmune diseases: systemic lupus erythematosus (SLE) with and without renal involvement, idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc).The purpose of this trial is to evaluate the safety and tolerability of ALLO-329, an allogeneic anti-CD19, anti-CD70 dual chimeric antigen receptor (CAR) T cell therapy, in adults with autoimmune disorders, provide initial evidence of biological activity and clinical response to the treatment and determine the recommended Phase 2 regimen (RP2R). | Lupus | Phase 1 | Immunomodulation + Thérapie cellulaire | United States, Canada | À vérifier |
| CyclophosphamideThis randomized phase II trial studies how well paclitaxel with or without carboplatin and/or bevacizumab followed by doxorubicin and cyclophosphamide works in treating patients with breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as paclitaxel, carboplatin, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bevacizumab may stop the growth of tumor cells by blocking blood flow to the tumor. Giving chemotherapy together with bevacizumab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. | Cancer | Phase 2 | Thérapie cellulaire | United States | À vérifier |
Essais cliniques
3| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Cyclophosphamide | Cancer | Phase 2 | NCT07524530 | Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers | NOT_YET_RECRUITING |
| ALLO-329 | Lupus | Phase 1 | NCT07085104 | RESOLUTION — A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease | RECRUITING |
| Cyclophosphamide | Lupus | NA | NCT03492255 | CYCLONES - CYClophosphamide LOw Dose and No Extra Steroid | TERMINATED |
Publications
26| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Fludarabine | Impact of fludarabine exposure on CAR T-cell outcomes in patients with large B-cell lymphoma. | Blood advances | ||
| Fludarabine | Tailored conditioning for hematopoietic stem cell transplantation in children with Mendelian susceptibility to mycobacterial disease: A tale of two pathways for IFN-γ and IL-12 defects. | Journal of human immunity | ||
| Fludarabine | Targeting IMPDH to inhibit SAMHD1 in -rearranged leukaemia. | Cell cycle (Georgetown, Tex.) | ||
| Cyclophosphamide | A systematic assessment of the short- and long-term effects of commonly used breast cancer chemotherapeutics on the gut microbiome‒blood‒brain axis of female mice. | Gut microbes | ||
| Cyclophosphamide | Investigating and validating the molecular mechanisms of lipid metabolism regulation in myasthenia gravis development based on single-cell, bulk transcriptomics, and RT-qPCR. | Autoimmunity | ||
| Cyclophosphamide | Multi-omics reveals the mechanism of Rehmannia glutinosa Libosch. Processed with Amomum villosum Lour. in treating blood deficiency syndrome. | Journal of ethnopharmacology | ||
| Fludarabine | A phase II study of low dose melphalan with thiotepa and fludarabine as preparative regimen for alternative donor transplantation. | Leukemia & lymphoma | ||
| Fludarabine | The discovery of potent and selective N-modified adenosine derivatives as effective chemotherapeutic agents to overcome p53-dependent drug resistance in cancer and HPIV-3/AdV5 respiratory tract infections. | Bioorganic chemistry | ||
| Cyclophosphamide | SP-3 Ameliorates Established Cyclophosphamide-Induced Liver Injury and Is Associated with PPAR-Related Transcriptional and Lipid-Metabolic Changes. | International journal of molecular sciences | ||
| Cyclophosphamide | Amyloidosis and Thoracic Aortic Disease: A Scoping Review. | Journal of clinical medicine | ||
| Cyclophosphamide | [Sustained complete remission achieved with tofacitinib in a refractory T-cell large granular lymphocytic leukemia]. | La Revue de medecine interne | ||
| Cyclophosphamide | Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in sickle cell disease: a narrative review of safety, engraftment, and graft-versus-host-disease outcomes in adults and high-risk populations. | Bone marrow transplantation | ||
| Cyclophosphamide | Alleviation effect of Potentilla anserina polysaccharides on intestinal barrier dysfunction and its underlying mechanism. | International journal of biological macromolecules | ||
| Cyclophosphamide | Real-world outcomes of BrECADD therapy in advanced-stage classical Hodgkin lymphoma: A multicentre retrospective study. | British journal of haematology | ||
| Fludarabine | Efficacy and safety of mitoxantrone hydrochloride liposome/ thiotepa/ busulfan/fludarabine (MTBF) conditioning regimen for salvage allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory acute myeloid leukemia: A single - Arm prospective clinical trial. | Cell transplantation | ||
| Cyclophosphamide | Salvage ultra-low-dose radiotherapy for conjunctival mantle cell lymphoma - a case report and literature review. | Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology | ||
| Cyclophosphamide | Application Timing-Dependent Impact of Donor Source on Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation for Adult T-Cell Leukemia/Lymphoma. | Hematological oncology | ||
| Cyclophosphamide | Breakthrough reactions in pediatric chemotherapeutic desensitization: Outcomes and associated risk factors. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology | ||
| Cyclophosphamide | Multi-omics integration reveals that pterostilbene ameliorates cyclophosphamide-induced liver injury the gut-liver axis by inhibiting inflammation and oxidative stress. | Food & function | ||
| Fludarabine | Novel pathological genetic variant associated with DOCK8 deficiency: case report with successful hematopoietic stem cell transplantation. | Allergologia et immunopathologia | ||
| Fludarabine | Precision myeloablation with TDM-guided busulfan in pediatric primary immunodeficiencies: a real-world study of 28 patients. | Translational pediatrics | ||
| Cyclophosphamide | Dermatomyositis With Necrotizing Vasculitis, Pulmonary Arterial Hypertension, and Extensive Calcinosis Following Delayed Diagnosis. | Cureus | ||
| Fludarabine | Radioimmunotherapy as a targeted strategy of reduced-intensity conditioning for allogeneic transplantation in leukemia. | Frontiers in oncology | ||
| Fludarabine | Fludarabine combined with treosulfan or total body irradiation as a conditioning therapy before allogeneic hematopoietic stem cell transplantation in acute lymphoblastic leukemia. A retrospective matched-pair analysis from the ALWP of the EBMT. | Bone marrow transplantation | ||
| Cyclophosphamide | Refractory Malignant Pericardial Effusion as the Initial Presentation of Early T-Cell Precursor Acute Lymphoblastic Leukemia/Lymphoma. | Cureus | ||
| Cyclophosphamide | Incidence and impact of odontogenic infection-related febrile episodes during perioperative doxorubicin-cyclophosphamide or docetaxel-cyclophosphamide chemotherapy for breast cancer. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer |